The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Early detection of pancreatic cancer: Where are we now and where are we going?
Abstract
Pancreatic cancer (PC) is one of the most lethal malignancies. Recent studies indicate that patients with incidentally diagnosed PC have better prognosis than those with symptoms and that there is a sufficient window for early detection. However, effective early diagnosis remains difficult and depends mainly on imaging modalities and the development of screening methodologies with highly sensitive and specific biomarkers. This review summarizes recent advances in effective screening for early diagnosis of PC using imaging modalities and novel molecular biomarkers discovered from various “omics” studies including genomics, epigenomics, non‐coding RNA, metabonomics, liquid biopsy (CTC, ctDNA and exosomes) and microbiomes, and their use in body fluids (feces, urine and saliva). Although many biomarkers for early detection of PC have been discovered through various methods, larger scale and rigorous validation is required before their application in the clinic. In addition, more effective and specific biomarkers of PC are urgently needed.
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Cites
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Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
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Whole genomes redefine the mutational landscape of pancreatic cancer
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“Recurrent somatic mutations encoding epigenome regulators of PC have been identified, including the SWI/SNF complex and the histone-lysine Nmethyltransferase 2 (KMT2) family.(24,25) These DNA methylation alterations in the pancreatic juice can be used for early detection of PC even though their functional role is not…”
BackgroundDistant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
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“Recurrent somatic mutations encoding epigenome regulators of PC have been identified, including the SWI/SNF complex and the histone-lysine Nmethyltransferase 2 (KMT2) family.(24,25) These DNA methylation alterations in the pancreatic juice can be used for early detection of PC even though their functional role is not…”
BackgroundWhole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W.-C., Mansour, J., Mollaee, M., Wagner, K.-U., Koduru, P., Yopp, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7744 · Cited by 1,115
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826
Cited by
Multicenter study of early pancreatic cancer in Japan
Kanno, A., Masamune, A., Hanada, K., Maguchi, H., Shimizu, Y., Ueki, T., Hasebe, O., Ohtsuka, T., Nakamura, M., Takenaka, M., et al. (2018) · Pancreatology · doi:10.1016/j.pan.2017.11.007 · Cited by 291
Circulating Tumor DNA—A Novel Biomarker of Tumor Progression and Its Favorable Detection Techniques
Wen, X., Pu, H., Liu, Q., Guo, Z., & Luo, D. (2022) · Cancers · doi:10.3390/cancers14246025 · Cited by 99
Ma, H., Liu, Z.-X., Zhang, J.-J., Wu, F.-T., Xu, C.-F., Shen, Z., Yu, C.-H., & Li, Y.-M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i34.5156 · Cited by 84
Toshima, F., Watanabe, R., Inoue, D., Yoneda, N., Yamamoto, T., Sasahira, N., Sasaki, T., Matsuyama, M., Minehiro, K., Tateishi, U., et al. (2021) · American Journal of Roentgenology · doi:10.2214/ajr.21.26014 · Cited by 81
Evaluation of KRAS inhibitor-directed therapies for pancreatic cancer treatment
Long, S.-A., Amparo, A. M., Goodhart, G., Ahmad, S. A., & Waters, A. M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1402128 · Cited by 31
Metadata
- Authors
- Zhou, B., Xu, J., Cheng, Y., Gao, J., Hu, S., Wang, L., & Zhan, H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2017-03-19
- Volume
- 141
- Issue
- 2
- Pages
- 231-241
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2592447625
- Cited by
- 209
- References
- 18
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhou, B., Xu, J., Cheng, Y., Gao, J., Hu, S., Wang, L., & Zhan, H. (2017). Early detection of pancreatic cancer: Where are we now and where are we going? International Journal of Cancer. https://doi.org/10.1002/ijc.30670
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
