Cited by 175Occupational Health and PerformanceGlobal Cancer Incidence and ScreeningOccupational and environmental lung diseases

Cancer incidence and mortality among firefighters

Open access
Jalilian, Hamed, Ziaei, Mansour, Weiderpass, Elisabete, Rueegg, Corina Silvia, Khosravi, Yahya, Kjaerheim, Kristina·2019·International Journal of Cancer

Abstract

Firefighters are exposed to both known and suspected carcinogens. This study aims to systematically review the literature on the association of firefighting occupation and cancer incidence and mortality, overall and for specific cancer sites. A systematic review using PubMed, Embase, and Web of Science was performed up to January 1, 2018. We extracted risk estimates of cancers and calculated summary incidence risk estimates (SIRE), summary mortality risk estimates (SMRE), and their 95% confidence intervals (CI). Publication bias and risk of bias in individual studies were assessed using Begg's and Egger's tests and the Newcastle-Ottawa scale (NOS), respectively. We included 50 papers in the review and 48 in the meta-analysis. We found significantly elevated SIREs for cancer of the colon (1.14; CI 1.06 to 1.21), rectum (1.09; CI 1.00 to 1.20), prostate (1.15; CI 1.05 to 1.27), testis (1.34; CI 1.08 to 1.68), bladder (1.12; CI 1.04 to 1.21), thyroid (1.22; CI 1.01 to 1.48), pleura (1.60; CI 1.09 to 2.34), and for malignant melanoma (1.21; CI 1.02 to 1.45). We found significant SMREs of 1.36 (1.18 to 1.57) and 1.42 (1.05 to 1.90) for rectal cancer and Non-Hodgkin's lymphoma, respectively. Considering the significantly elevated risk of some cancers in this occupational group, we suggest improving preventive measures and securing adequate and relevant medical attention for this group. Further studies with more accurate and in-depth exposure assessments are indicated.

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  • Physical and psychological stressors encountered every working shift lead to increased risk for major health conditions such as cardiovascular disease, cancer, and depression in firefighters.

    “These physical and psychological stressors encountered every working shift have been shown to lead to increased risk for major health conditions such as cardiovascular disease, cancer, and depression [7,8,9].”

    From The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review (2024) · cites this paper as [8]

    The Introduction describes firefighters’ occupational exposure to carcinogens, and Implications of our study reports increased risk of some cancers. The cited paper does not establish that stressors encountered every shift cause cardiovascular disease or depression in firefighters, or that the exposures it discusses occur every shift. (LLM, conf=0.88)

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5 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Berg JW, Howell MA. Occupation and bowel can- cer. J Toxicol Env Heal A 1975;1:75-89.
  2. IARC Working Group on the Evaluation of Carci- nogenic Risks to Humans. Arsenic, metals, fibres, and dusts. IARC Monogr Eval Carcinog Risks Hum 2012;100:11-465.
  3. Schottenfeld D, Fraumeni JF Jr. Cancer epidemiol- ogy and prevention, 4th edn. New York, NY: Oxford University Press, 2006.
  4. IARC Working Group on the Evaluation of Carci- nogenic Risks to Humans. Personal habits and indoor combustions volume 100e A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 2012;100:1-538.

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Authors
Jalilian, H., Ziaei, M., Weiderpass, E., Rueegg, C. S., Khosravi, Y., & Kjaerheim, K.
Affiliations
  • Hormozgan University of Medical Sciences (IR)
  • Bushehr University of Medical Sciences (IR)
  • University of Helsinki (FI)
  • Oslo University Hospital (NO)
  • Alborz University of Medical Sciences (IR)
  • Department of Research Cancer Registry of Norway ‐ Institute of Population‐Based Cancer Research Oslo Norway
Corresponding author
Khosravi, Yahya
Venue
International Journal of Cancer
Publisher
Wiley
Published
2019-03
Volume
145
Issue
10
Pages
2639-2646
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
OpenAlex
W2913794613
Cited by
175
References
102
Citations by year
2026: 11 · 2025: 16 · 2024: 31 · 2023: 32 · 2022: 23 · 2021: 28 · 2020: 28 · 2019: 6
FWCI
5.66
Type
journal article
Language
en
Open access
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Bushehr University of Medical Sciences Repository (Bushehr University of Medical Sciences) (submittedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders
  • Alborz University of Medical Sciences (1396‐02‐22‐1579)
  • Seventh Framework Programme (609020)
Topics
  • Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Performance
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords
firefighters, occupational cancer, cancer incidence, cancer mortality, occupational exposure, carcinogens, colon cancer, rectal cancer, prostate cancer, testicular cancer, bladder cancer, thyroid cancer, pleural cancer, melanoma, non-Hodgkin lymphoma, cancer risk estimates
MeSH terms
Carcinogens, Humans, Neoplasms, Incidence, Survival Analysis, Occupational Exposure, Risk Assessment, Firefighters

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