Cited by 74Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity StudiesMedical Image Segmentation Techniques

A multi-modal, multi-atlas-based approach for Alzheimer detection via machine learning

Asim, Yousra, Raza, Basit, Malik, Ahmad Kamran, Rathore, Saima, Hussain, Lal, Iftikhar, Mohammad Aksam·2018·International Journal of Imaging Systems and Technology

Abstract

The use of biomarkers for early detection of Alzheimer's disease (AD) improves the accuracy of imaging‐based prediction of AD and its prodromal stage that is mild cognitive impairment (MCI). Brain parcellation‐based computer‐aided methods for detecting AD and MCI segregate the brain in different anatomical regions and use their features to predict AD and MCI. Brain parcellation generally is carried out based on existing anatomical atlas templates, which vary in the boundaries and number of anatomical regions. This works considers dividing the brain based on different atlases and combining the features extracted from these anatomical parcellations for a more holistic and robust representation. We collected data from the ADNI database and divided brains based on two well‐known atlases: LONI Probabilistic Brain Atlas (LPBA40) and Automated Anatomical Labeling (AAL). We used baselines images of structural magnetic resonance imaging (MRI) and 18 F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) to calculate average gray‐matter density and average relative cerebral metabolic rate for glucose in each region. Later, we classified AD, MCI and cognitively normal (CN) subjects using the individual features extracted from each atlas template and the combined features of both atlases. We reduced the dimensionality of individual and combined features using principal component analysis, and used support vector machines for classification. We also ranked features mostly involved in classification to determine the importance of brain regions for accurately classifying the subjects. Results demonstrated that features calculated from multiple atlases lead to improved performance compared to those extracted from one atlas only.

Integrity signals

Registry

Crossref · 10.1002/ima.22263

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The choice of parcellation was based on the reproducibility criteria.

    “Thus, by considering the various studies that used the AAL atlas in dementia research, even with ML methods (Asim et al., 2018; Bachli et al., 2020; Castellazzi et al., 2020; Hao et al., 2020; McMillan et al., 2014; Park et al., 2022; Sedeño et al., 2017), our choice of parcellation was based on the reproducibility criteria.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Asim, Y., Raza, B., Malik, A. K., Rathore, S., Hussain, L., & Iftikhar, M. A.
Affiliations
  • COMSATS University Islamabad (PK)
  • University of Pennsylvania (US)
  • University of Azad Jammu and Kashmir (PK)
  • Department of Computer Science COMSATS Institute of Information Technology Lahore Pakistan
Venue
International Journal of Imaging Systems and Technology
Publisher
Wiley
Published
2018-01-10
Volume
28
Issue
2
Pages
113-123
ISSN
  • 0899-9457 (ISSN-L)
  • 1098-1098
OpenAlex
W2783144574
Cited by
74
References
38
Citations by year
2026: 5 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 12 · 2020: 6 · 2019: 9 · 2018: 3
FWCI
5.90
Type
journal article
Language
en
Open access
closed
Locations
International Journal of Imaging Systems and Technology (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
Keywords
Alzheimer's disease detection, mild cognitive impairment, automated anatomical labeling, gray matter density, cerebral metabolic rate, FDG-PET, structural MRI, multimodal fusion, support vector machine classification, feature ranking, ADNI

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review