The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Origin and evolution of retroelements based upon their reverse transcriptase sequences
Open accessAbstract
To study the evolutionary relationship of reverse transcriptase (RT) containing genetic elements, a phylogenetic tree of 82 retroelements from animals, plants, protozoans and bacteria was constructed. The tree was based on seven amino acid domains totalling 178 residues identified in all RTs. We have also identified these seven domains in the RNA-directed RNA polymerases from various plus-strand RNA viruses. The sequence similarity of these RNA polymerases to RT suggests that these two enzymes evolved from a common ancestor, and thus RNA polymerase can be used as an outgroup to root the RT tree. A comparison of the genetic organization of the various RT containing elements and their position on the tree allows several inferences concerning the origin and evolution of these elements. The most probable ancestor of current retroelements was a retrotransposable element with both gag-like and pol-like genes. On one major branch of the tree, organelle and bacterial sequences (e.g. group II introns and bacterial msDNA) appear to have captured the RT sequences from retrotransposons which lack long terminal repeats (LTRs). On the other major branch, acquisition of LTRs gave rise to two distinct groups of LTR retrotransposons and three groups of viruses: retroviruses, hepadnaviruses and caulimoviruses.
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“The retrotransposons consist of two subclasses, LTR and non-LTR retrotransposons, based on the phylogeny of RTase which they encodes.31”
From Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity (2016) · cites this paper as [31]
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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784
Luan, D. D., Korman, M. H., Jakubczak, J. L., & Eickbush, T. H. (1993) · Cell · doi:10.1016/0092-8674(93)90078-5 · Cited by 1,173
Self-citationHuman L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139
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Metadata
- Authors
- Xiong, Y., & Eickbush, T. H.
- Affiliations
- University of Rochester (US)
- ORCID
- Xiong, Y.
- Venue
- The EMBO Journal
- Published
- 1990-10-01
- Volume
- 9
- Issue
- 10
- Pages
- 3353-3362
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC552073
- OpenAlex
- W1554644662
- Cited by
- 1,374
- References
- 77
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 12 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 22 · 2017: 28 · 2016: 29 · 2015: 34 · 2014: 32 · 2013: 44 · 2012: 29
- FWCI
- 87.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- retroelements, reverse transcriptase, retrotransposons, RNA-dependent RNA polymerase, positive-strand RNA viruses, LTR retrotransposons, retroviral evolution, hepadnaviruses, group II introns, organelle DNA, common ancestor, horizontal gene transfer
- MeSH terms
- Amino Acid Sequence, Animals, DNA Transposable Elements, Biological Evolution, Humans, Introns, Molecular Sequence Data, Phylogeny, RNA-Directed DNA Polymerase, DNA-Directed RNA Polymerases, Sequence Homology, Nucleic Acid
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