The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
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Cites
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,664
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,139
Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,897
Guan, K., & Dixon, J. E. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,746
Self-citationRaf-1 activates MAP kinase-kinase
Kyriakis, J. M., App, H., Zhang, X.-F., Banerjee, P., Brautigan, D. L., Rapp, U. R., & Avruch, J. (1992) · Nature · doi:10.1038/358417a0 · Cited by 1,283
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248
Signal transduction via the MAP kinases: proceed at your own RSK.
Blenis, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5889 · Cited by 1,243
Hanks, S. K., & Quinn, A. M. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)00126-h · Cited by 1,217
Anderson, N. G., Maller, J. L., Tonks, N. K., & Sturgill, T. W. (1990) · Nature · doi:10.1038/343651a0 · Cited by 1,063
Payne, D. M., Rossomando, A. J., Martino, P., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., & Sturgill, T. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08021.x · Cited by 1,040
Cited by
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation
Delhase, M., Hayakawa, M., Chen, Y., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.309 · Cited by 852
Metadata
- Authors
- Zheng, C. F., & Guan, K. L.
- Venue
- The EMBO Journal
- Published
- 1994-03
- Volume
- 13
- Issue
- 5
- Pages
- 1123-1131
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W137936598
- Cited by
- 398
- References
- 56
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Zheng, C. F., & Guan, K. L. (1994). Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. The EMBO Journal. https://doi.org/10.1002/j.1460-2075.1994.tb06361.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.