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39 kDa receptor‐associated protein is an ER resident protein and molecular chaperone for LDL receptor‐related protein.
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RAP functions in the endoplasmic reticulum to assist in the maturation of several membrane receptor proteins, including LRP and SorLA/LR11.
“Receptor associated protein (RAP) functions in the endoplasmic reticulum (ER) to assist in the maturation of several membrane receptor proteins, including low density lipoprotein receptor-related protein (LRP) and lipoprotein receptor 11 (SorLA/LR11).”
From Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice (2008) · cites this paper as [11]
Maturation of LRP to the trans-Golgi network is partially dependent upon the presence of RAP, which binds to LRP at multiple sites to block the receptor's ability to interact with its ligands.
“Maturation of LRP to the trans-Golgi network is partially dependent upon the presence of LRP-receptor-associated protein (RAP), which binds to LRP at multiple sites to block the receptor's ability to interact with its ligands [11].”
From Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice (2008) · cites this paper as [11]
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Research works printed but not linked: 7
- Bu,G., Williams,S., Strickland,D.K. and Schwartz,A.L. (1992) Proc. Nati Acad. Sci. USA, 89, 7427-7431.
- Kowal,R.C., Herz,J., Goldstein,J.L., Esser,V. and Brown,M.S. (1989) Proc. Natl Acad. Sci. USA, 86, 5810-5814.
- Maxfield,F.R. and Yamashiro,D.J. (1991) In Steer,C.J. and Hanover,J.A. (eds), Intracellular Trafficking of Proteins. Cambridge University Press, Cambridge, pp. 157-182.
- Orth,K., Madison,E.L., Gething,M-J., Sambrook,J.F. and Herz,J. (1992) Proc. Natl Acad. Sci. USA, 89, 7422-7426.
- G.Bu et al. Pietromonaco,S., Kerjaschki,D., Binder,S., Ullrich,R. and Farquhar,M.G. (1990) Proc. Natl Acad. Sci. USA, 87, 1811-1815.
- Takakashi,S., Kawarabayasi,Y., Nakai,T., Sakai,J. and Yamamoto,T. (1992) Proc. Natl Acad. Sci. USA, 89, 9252-9256.
- Warshawsky,I., Broze,G.J.Jr and Schwartz,A.L. (1994) Proc. Natl Acad. Sci. USA, 91, 6664-6668.
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Self-citationShinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075796 · Cited by 297
Self-citationWillnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00623.x · Cited by 276
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
Liu, C.-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3442-16.2017 · Cited by 267
Self-citationLee, J., Retamal, C., Cuitiño, L., Caruano-Yzermans, A., Shin, J.-E., van Kerkhof, P., Marzolo, M.-P., & Bu, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800642200 · Cited by 162
Self-citationSorting nexin 17 facilitates LRP recycling in the early endosome
van Kerkhof, P., Lee, J., McCormick, L., Tetrault, E., Lu, W., Schoenfish, M., Oorschot, V., Strous, G. J., Klumperman, J., & Bu, G. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600756 · Cited by 148
Self-citationFuentealba, R. A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J.-M., LaDu, M. J., & Bu, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011884 · Cited by 116
Self-citationVan Uden, E., Mallory, M., Veinbergs, I., Alford, M., Rockenstein, E., & Masliah, E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09298.2002 · Cited by 91
GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation
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Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Li, Y., Chen, J., Lu, W., McCormick, L. M., Wang, J., & Bu, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02651 · Cited by 53
Self-citationThe endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
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Yamamoto, M., Ikeda, K., Ohshima, K., Tsugu, H., Kimura, H., & Tomonaga, M. (1998) · Brain Tumor Pathology · doi:10.1007/bf02482097 · Cited by 25
Xu, G., Karch, C., Li, N., Lin, N., Fromholt, D., Gonzales, V., & Borchelt, D. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003159 · Cited by 14
Metadata
- Authors
- Bu, G., Geuze, H. J., Strous, G. J., & Schwartz, A. L.
- Venue
- The EMBO Journal
- Published
- 1995-05-01
- Volume
- 14
- Issue
- 10
- Pages
- 2269-2280
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 274
- References
- 0
- Language
- en
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