Lipoprotein Receptors in the Nervous System

Herz, Joachim; Bock, Hans H.

doi:10.1146/annurev.biochem.71.110601.135342

Cited by 469Cholesterol and Lipid MetabolismAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.

Lipoprotein Receptors in the Nervous System

Herz, Joachim, Bock, Hans H.·2002·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.71.110601.135342

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Abstract

The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.

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ApoE binds to a group of structurally related proteins known as the LDL receptor family.
“ApoE binds to a group of structurally related proteins known as the low density lipoprotein receptor (LDLR) family.”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Herz and Bock, 2002
VLDLR and ApoER2 share the highest overall sequence homology with LDLR among the LDLR family.
“Among the LDLR family of proteins, the VLDLR (very low density lipoprotein receptor) and ApoER2 (also known as LRP8) share the highest overall sequence homology with the LDLR (14).”
From The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2 (2010) · cites this paper as [14]
The high degree of evolutionary conservation within the LDLR family of receptors prompted the investigation of substrate specificity of IDOL.
“Our investigation of the substrate specificity of IDOL was largely prompted by the high degree of evolutionary conservation within the LDLR family of receptors (14).”
From The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2 (2010) · cites this paper as [14]
ApoE receptors are members of the low-density lipoprotein receptor gene family that play important roles in maintaining the proper function of neurons.
“ApoE receptors are members of the low-density lipoprotein receptor gene family that play important roles in maintaining the proper function of neurons (Herz and Bock, 2002).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Herz and Bock, 2002
The ligands for LRP1 include several proteins already implicated in AD pathogenesis, such as apoE, APP, Aβ, α2-macroglobulin, matrix metallopeptidase 9, and tissue-type plasminogen activator.
“The ligands for LRP1 include several proteins already implicated in AD pathogenesis, such as apoE, APP, Aβ, α2-macroglobulin, matrix metallopeptidase 9, and tissue-type plasminogen activator (Herz and Bock, 2002).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Herz and Bock, 2002

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Authors: Herz, J., & Bock, H. H.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Herz, Joachim
Bock, Hans H.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2002-06
Volume: 71
Issue: 1
Pages: 405-434
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.71.110601.135342
OpenAlex: W2149816215
Cited by: 457
References: 202
Citations by year: 2026: 6 · 2025: 12 · 2024: 14 · 2023: 18 · 2022: 19 · 2021: 11 · 2020: 16 · 2019: 13 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 21 · 2013: 12 · 2012: 20
FWCI: 6.54
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R37HL063762)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: low-density lipoprotein receptor family, lipoprotein receptors, nervous system, brain, receptor signaling, lipid metabolism, vitamin metabolism, proteolytic activity, cell surface receptors, brain development, neuroprotection
MeSH terms: Reelin Protein, Animals, Apolipoproteins E, Brain, Central Nervous System, Cholesterol, Multigene Family, Learning, Ligands, Nerve Tissue Proteins, Proto-Oncogene Proteins, Receptors, LDL, Serine Endopeptidases, Signal Transduction, Trans-Activators, Cell Adhesion Molecules, Neuronal, Receptors, N-Methyl-D-Aspartate, Extracellular Matrix Proteins, Protein Transport, Caveolae, Membrane Microdomains, Zebrafish Proteins, Wnt Proteins, Hedgehog Proteins

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Lipoprotein Receptors in the Nervous System

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