The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans
Abstract
Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of caffeine in a randomized, double‐blind, single‐dose crossover study. Caffeine kinetics were nonlinear, with clearance significantly reduced and elimination half‐life prolonged at the 500‐mg compared to the 250‐mg dose. The lower dose of caffeine produced more favorable subjective effects than the higher dose (elation, peacefulness, pleasantness), whereas unpleasant effects (tension, nervousness, anxiety, excitement, irritability, nausea, palpitations, restlessness) following the 500‐mg dose exceeded those of the 250‐mg dose. The lower dose of caffeine enhanced performance on the digit symbol substitution test and a tapping speed test compared to placebo; high‐dose caffeine produced less performance enhancement than the lower dose. The plasma concentration versus response relationship revealed concentration‐dependent increases in anxiety and improvements in cognitive and motor performance at low to intermediate concentrations. Both caffeine doses reduced electroencephalographic amplitude over the 4 Hz to 30 Hz spectrum, as well as in the alpha (8–11 Hz) and beta (12–30 Hz) ranges; however, effects were not dose‐dependent. While favorable subjective and performance‐enhancing stimulant effects occur at low to intermediate caffeine doses, the unfavorable subjective and somatic effects, as well as performance disruption, from high doses of caffeine may intrinsically limit the doses of caffeine used in the general population.
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Cites
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Increased Anxiogenic Effects of Caffeine in Panic Disorders
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Withdrawal Syndrome after the Double-Blind Cessation of Caffeine Consumption
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Sensitivity to triazolam in the elderly
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Self-citationvon Moltke, L. L., Greenblatt, D. J., Harmatz, J. S., Duan, S. X., Harrel, L. M., Cotreau-Bibbo, M. M., Pritchard, G. A., Wright, C. E., & Shader, R. I. (1996) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12284-2 · Cited by 225
Self-citationCaffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms
Tassaneeyakul, W., Birkett, D. J., McManus, M. E., Tassaneeyakul, W., Veronese, M. E., Andersson, T., Tukey, R. H., & Miners, J. O. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90304-2 · Cited by 198
Cited by
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Heckman, M. A., Weil, J., & De Mejia, E. G. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01561.x · Cited by 908
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
“In epidemiological reports, caffeine consumption was associated with a significantly lower risk of developing them [4, 11, 12, 120-122, 124].”
BackgroundScientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
Is Caffeine a Cognitive Enhancer?
Nehlig, A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091315 · Cited by 411
Metadata
- Authors
- Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1997-08
- Volume
- 37
- Issue
- 8
- Pages
- 693-703
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2162252433
- Cited by
- 386
- References
- 36
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997). Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans. The Journal of Clinical Pharmacology. https://doi.org/10.1002/j.1552-4604.1997.tb04356.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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