Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.
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During inflammation, the superoxide anion (O-2) and hydrogen peroxide (H2O2) are produced by stimulated polymorphonuclear leukocytes and macrophages. The toxic effects of these reactive oxygen intermediates increase when traces of iron are present, because iron catalyzes the formation of the hydroxyl radical (OH.). Partially saturated iron-binding proteins, such as transferrin and ferritin, are unable to catalyze OH. formation in vitro. Mobilization of iron from these proteins is necessary for iron stimulation of OH. formation. This paper reports that stimulated polymorphonuclear leukocytes mobilize iron from human and horse ferritin, but not from human transferrin. Iron release from ferritin depends on O-2 because it can be prevented by the addition of superoxide dismutase. Catalase and dimethylsulfoxide have no inhibitory effect on iron mobilization. The efficiency of the iron release increases at low levels of O-2 production. Only O-2 produced by granulocytes is sufficient for iron mobilization, because solid potassium superoxide is also able to release iron from ferritin. We propose that this reaction may potentiate the formation of the OH. radical in inflammatory states.
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A mechanism in RA involves elevated superoxide liberating free iron from ferritin in synovial fluid, thereby catalysing further damaging production of hydroxyl radicals.
“a mechanism [1256-1259] in which elevated superoxide liberates free iron from ferritin in synovial fluid (and elsewhere [1260]), thereby catalysing further the damaging production of hydroxyl radicals.”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1259]
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- Authors
- Biemond, P., van Eijk, H. G., Swaak, A. J., & Koster, J. F.
- Affiliations
- Daniel den Hoed Kliniek (NL)
- Venue
- Journal of Clinical Investigation
- Published
- 1984-06-01
- Volume
- 73
- Issue
- 6
- Pages
- 1576-1579
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC437068
- OpenAlex
- W2015854329
- Cited by
- 380
- References
- 21
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 11 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 10
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- ferritin, iron mobilization, superoxide, polymorphonuclear leukocytes, hydroxyl radical generation, inflammation, reactive oxygen species, superoxide dismutase, transferrin, catalase, potassium superoxide, iron-catalyzed oxidation, granulocytes
- MeSH terms
- Animals, Catalase, Dimethyl Sulfoxide, Ferritins, Horses, Humans, Inflammation, Iron, Neutrophils, Spleen, Superoxides, Superoxide Dismutase, Transferrin
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