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Cited by 259Hormonal and reproductive studiesSexual function and dysfunction studiesHypothalamic control of reproductive hormones

A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men

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BURRIS, ALLEN S., BANKS, STEVEN M., CARTER, C. SUE, DAVIDSON, JULIAN M., SHERINS, RICHARD J.·1992·Journal of Andrology
DOI 10.1002/j.1939-4640.1992.tb00319.x
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Abstract

ABSTRACT: This study describes sexual activity, nocturnal penile erections, and mood states as a function of serum levels of androgens in previously untreated hypogonadal men before and during hormone replacement, selected infertile men (elevated serum follicle‐stimulating hormone levels), and normal men. Nocturnal penile tumescence and rigidity were measured with a portable monitor, and sexual activity and mood were assessed by prospective, self‐reported written forms. Nocturnal erections were absent or of very low amplitude and duration in the untreated hypogonadal men compared to the infertile and normal men. Nocturnal erections increased steadily during hormone replacement and were in the normal range within 6 to 12 months of treatment. In contrast, serum testosterone concentration rapidly reached the upper range of normal. During treatment, the hypogonadal men reported increases in several aspects of sexual activity, including sexual interest and the number of spontaneous erections. On mood inventories, the untreated hypogonadal men scored significantly higher in ratings of depression, anger, fatigue, and confusion than did infertile and normal men. During hormonal replacement therapy these scores decreased, although the hypogonadal men continued to score higher in “depression” than did infertile and normal men. In most instances, the men with infertility and the normal men were statistically indistinguishable in nocturnal penile tumescence and rigidity parameters, self‐reported sexual activity, and mood state. These data support the hypothesis that androgen treatment increases nocturnal and spontaneous erections, and sexual interest, and has some capacity to improve mood.

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  • Testosterone replacement increases libido, sexual motivation and sexual function, mood, sense of well-being, concentration, self-reported sense of energy, muscle mass and strength, and recovery of anemia related to testosterone deficiency.

    “T replacement increases libido, sexual motivation and sexual function (134,135,138-143), mood (144), sense of well being, concentration (135,139,143,145-147), self-reported sense of energy (134,135), muscle mass and strength (132,148,149), and the recovery of anemia related to T deficiency (134).”

    From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [141]

    The Sexual Activity and Mood State section reports increased sexual interest, potency, spontaneous erections and vigor during hormone replacement in previously untreated hypogonadal men. It also reports improvements in mood measures. The paper does not establish the claimed gains in concentration, muscle mass or strength, or recovery from anemia. (LLM, conf=0.86)

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Authors
BURRIS, A. S., BANKS, S. M., CARTER, C. S., DAVIDSON, J. M., & SHERINS, R. J.
Affiliations
  • National Institutes of Health (US)
  • University of Maryland, College Park (US)
  • Stanford University (US)
Corresponding author
CARTER, C. SUE
ORCID
CARTER, C. SUE
Venue
Journal of Andrology
Publisher
Wiley
Published
1992-07-08
Volume
13
Issue
4
Pages
297-304
ISSN
  • 0196-3635 (ISSN-L)
  • 1939-4640
DOI
10.1002/j.1939-4640.1992.tb00319.x
OpenAlex
W1537046417
Semantic Scholar
406a86ac0970dd7cdbd4d04d0f10207b4e8d70d3
Cited by
259
References
21
Citations by year
2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 9
FWCI
2.92
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7483 d)
Locations
  • Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
male hypogonadism, testosterone replacement therapy, nocturnal penile tumescence, sexual activity, sexual interest, mood, depression, infertility, follicle-stimulating hormone, androgens, spontaneous erections
MeSH terms
Adult, Affect, Analysis of Variance, Androgens, Follicle Stimulating Hormone, Humans, Hypogonadism, Infertility, Male, Luteinizing Hormone, Male, Orgasm, Penile Erection, Prospective Studies, Sexual Behavior, Sex Hormone-Binding Globulin, Testosterone, Time Factors

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