Somatic and psychological effects of low-dose aromatase inhibition in men with obesity-related hypogonadotropic hypotestosteronemia
Open accessAbstract
Introduction: Reduced testosterone levels are frequently observed in obese men. Increased aromatase activity may be an etiological factor. Objective: In this study, we evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypotestosteronemia (OrHH). Methods: Double-blind, placebo-controlled, 6-month trial in 42 obese men with a BMI >35 kg/m 2, and a serum total testosterone <10 nmol/l. All patients started on one tablet of 2.5 mg/week, with subsequent dose escalation every month until a serum total testosterone of 20 nmol/l was reached. Endpoints: Psychological function, body composition, exercise capacity, and glucose, lipid, and bone metabolism. Results: Thirty-nine patients completed the study according to protocol. Letrozole decreased serum estradiol from 119.1±10.1 to 59.2±6.1 pmol/l (P<0.001), and increased serum LH from 3.3±0.3 to 8.8±0.9 U/l (P<0.0001) and serum total testosterone from 8.6±0.7 to 21.5±1.3 nmol/l (P<0.0001). Significant effects on the predefined endpoints were not observed. Conclusion: Despite a marked rise in serum testosterone, low-dose aromatase inhibition had no somatic or psychological effects in men with OrHH.
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- Authors
- Loves, S., de Jong, J., van Sorge, A., Telting, D., Tack, C. J., Hermus, A., Westerterp, K., & de Boer, H.
- Affiliations
- Rijnstate Hospital (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Corresponding author
- Loves, Sandra
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11
- Volume
- 169
- Issue
- 5
- Pages
- 705-714
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2157274344
- Cited by
- 45
- References
- 41
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 6
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- aromatase inhibition, letrozole, testosterone replacement therapy, estradiol, luteinizing hormone, body composition, exercise capacity, bone metabolism, lipid metabolism, glucose metabolism, psychological functioning, obese men
- MeSH terms
- Letrozole, Adult, Androgens, Blood Glucose, Body Composition, Energy Intake, Double-Blind Method, Estradiol, Hormones, Humans, Hypogonadism, Luteinizing Hormone, Male, Middle Aged, Neuropsychological Tests, Nitriles, Obesity, Morbid, Psychometrics, Testosterone, Triazoles, Bone Density, Body Mass Index, Exercise Tolerance, Aromatase Inhibitors, Lipid Metabolism
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