Cited by 117Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsSexual Differentiation and Disorders

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Cognitive Changes Associated With Supplementation of Testosterone or Dihydrotestosterone in Mildly Hypogonadal Men: A Preliminary Report

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Cherrier, Monique M., Craft, Suzanne, Matsumoto, Alvin H.·2003·Journal of Andrology

DOI 10.1002/j.1939-4640.2003.tb02708.x

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Abstract

ABSTRACT: This study prospectively examined changes in cognition in hypogonadal men given testosterone (T) or older hypogonadal men given dihydrotestosterone (DHT) gel. A battery of cognitive tests assessing verbal and spatial memory, language, and attention was administered at baseline (prior to medication) and again at days 90 and 180 of treatment for men receiving T gel and at baseline and days 30 and 90 of treatment for men receiving DHT gel. For men receiving T gel, circulating total T and estradiol (E 2) were significantly raised compared with baseline, and a significant improvement in verbal memory was observed. For men receiving DHT gel, serum DHT levels increased and T levels decreased significantly compared with baseline, and a significant improvement in spatial memory was observed. The results suggest that beneficial changes in cognition can occur in hypogonadal men using T replacement levels and DHT treatment, and these changes in cognition can be reliably measured during a relative steady‐state dose level. Further, our results suggest that aromatization of T to E 2 may regulate verbal memory in men, whereas nonaromatizable androgens may regulate spatial memory.

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Authors: Cherrier, M. M., Craft, S., & Matsumoto, A. H.
Affiliations: University of Washington (US)
Corresponding author: Cherrier, Monique M.
ORCID: Cherrier, Monique M.
Craft, Suzanne
Venue: Journal of Andrology
Publisher: Wiley
Published: 2003-07-08
Volume: 24
Issue: 4
Pages: 568-576
ISSN: 0196-3635 (ISSN-L)
1939-4640
DOI: 10.1002/j.1939-4640.2003.tb02708.x
OpenAlex: W1661237936
Semantic Scholar: f942bf564e26f6e6f935130ace633f665df12b5f
Cited by: 117
References: 82
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 6
FWCI: 3.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3466 d)
Locations: Journal of Andrology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG00858)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: testosterone replacement therapy, dihydrotestosterone, hypogonadism, cognitive function, verbal memory, spatial memory, estradiol, aromatization, androgens, attention, language
MeSH terms: Adult, Aged, Androgens, Attention, Cognition, Humans, Hypogonadism, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Space Perception, Dihydrotestosterone, Testosterone, Verbal Learning

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Cognitive Changes Associated With Supplementation of Testosterone or Dihydrotestosterone in Mildly Hypogonadal Men: A Preliminary Report

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