Cited by 898Drug Transport and Resistance MechanismsLiver physiology and pathologyIon Transport and Channel Regulation

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Bile Formation and Secretion

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Boyer, James L.·2013·Comprehensive Physiology

DOI 10.1002/j.2040-4603.2013.tb00519.x

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Abstract

Bile is a unique and vital aqueous secretion of the liver that is formed by the hepatocyte and modified down stream by absorptive and secretory properties of the bile duct epithelium. Approximately 5% of bile consists of organic and inorganic solutes of considerable complexity. The bile‐secretory unit consists of a canalicular network which is formed by the apical membrane of adjacent hepatocytes and sealed by tight junctions. The bile canaliculi (∼1 μm in diameter) conduct the flow of bile countercurrent to the direction of portal blood flow and connect with the canal of Hering and bile ducts which progressively increase in diameter and complexity prior to the entry of bile into the gallbladder, common bile duct, and intestine. Canalicular bile secretion is determined by both bile salt‐dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate‐binding cassette transport proteins that function as export pumps for bile salts and other organic solutes. These transporters create osmotic gradients within the bile canalicular lumen that provide the driving force for movement of fluid into the lumen via aquaporins. Species vary with respect to the relative amounts of bile salt‐dependent and independent canalicular flow and cholangiocyte secretion which is highly regulated by hormones, second messengers, and signal transduction pathways. Most determinants of bile secretion are now characterized at the molecular level in animal models and in man. Genetic mutations serve to illuminate many of their functions. © 2013 American Physiological Society. Compr Physiol 3:1035‐1078, 2013.

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Authors: Boyer, J. L.
Affiliations: Yale University (US)
Corresponding author: Boyer, James L.
Venue: Comprehensive Physiology
Publisher: Wiley
Published: 2013-07
Volume: 3
Issue: 3
Pages: 1035-1078
ISSN: 2040-4603 (ISSN-L)
DOI: 10.1002/j.2040-4603.2013.tb00519.x
OpenAlex: W4409112708
Cited by: 124
References: 596
Citations by year: 2026: 31 · 2025: 38 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1
FWCI: 0.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive physiology (publishedVersion)
Funders: National Institutes of Health (DK25636)
U.S. Public Health Service (DK25636)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: bile formation, bile secretion, hepatocytes, bile canaliculi, ABC transporters, bile salt transport, cholangiocytes, bile duct epithelium, aquaporins, osmotic gradient

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