Bile Formation and Secretion

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

Gottesman, M. M., & PASTAN, I. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002125 · Cited by 3,569

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M., Pastan, I., & Willingham, M. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.21.7735 · Cited by 2,823

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. H., & Gottesman, M. M. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.361 · Cited by 2,059

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J., & Cox, D. W. (1993) · Nature Genetics · doi:10.1038/ng1293-327 · Cited by 1,939

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption

Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G. G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., et al. (2004) · Science · doi:10.1126/science.1093131 · Cited by 1,818

Primary sclerosing cholangitis – a comprehensive review

Karlsen, T. H., Folseraas, T., Thorburn, D., & Vesterhus, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.022 · Cited by 868

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

Arab, J. P., Karpen, S. J., Dawson, P. A., Arrese, M., & Trauner, M. (2017) · Hepatology · doi:10.1002/hep.28709 · Cited by 634

Oxidative Stress in Liver Pathophysiology and Disease

Allameh, A., Niayesh‐Mehr, R., Aliarab, A., Sebastiani, G., & Pantopoulos, K. (2023) · Antioxidants · doi:10.3390/antiox12091653 · Cited by 606

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Fleishman, J. S., & Kumar, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01811-6 · Cited by 615

Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., LaRusso, N. F., & Gores, G. J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0125-y · Cited by 517

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

Fuchs, C. D., & Trauner, M. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00566-7 · Cited by 490

Molecular physiology of bile acid signaling in health, disease, and aging

Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018) · Microorganisms · doi:10.3390/microorganisms6030075 · Cited by 465

The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms

Meech, R., Hu, D. G., McKinnon, R. A., Mubarokah, S. N., Haines, A. Z., Nair, P. C., Rowland, A., & Mackenzie, P. I. (2019) · Physiological Reviews · doi:10.1152/physrev.00058.2017 · Cited by 379

Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer

Li, T., & Apte, U. M. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.003 · Cited by 336

Programmed and self-organized flow of information during morphogenesis

Collinet, C., & Lecuit, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00318-6 · Cited by 322

The cell biology of the hepatocyte: A membrane trafficking machine

Schulze, R. J., Schott, M. B., Casey, C. A., Tuma, P. L., & McNiven, M. A. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201903090 · Cited by 281

Mechanisms of bile acid mediated inflammation in the liver

Li, M., Cai, S., & Boyer, J. L. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.001 · Cited by 275

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion

van Leeuwen, O. B., de Vries, Y., Fujiyoshi, M., Nijsten, M. W., Ubbink, R., Pelgrim, G. J., Werner, M. J. M., Reyntjens, K. M. E. M., van den Berg, A. P., de Boer, M. T., et al. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003540 · Cited by 258

Microbiota Metabolites in Health and Disease

McCarville, J. L., Chen, G. Y., Cuevas, V. D., Troha, K., & Ayres, J. S. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071219-125715 · Cited by 255

Bile salts in digestion and transport of lipids

Macierzanka, A., Torcello‐Gómez, A., Jungnickel, C., & Maldonado‐Valderrama, J. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.102045 · Cited by 227

Functions of the Gallbladder

Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150050 · Cited by 226

Metabolic Messengers: bile acids

Perino, A., & Schoonjans, K. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00559-z · Cited by 223

Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals

McClements, D. J., & Xiao, H. (2014) · Food & Function · doi:10.1039/c4fo00100a · Cited by 219

Bile Acids and FXR: Novel Targets for Liver Diseases

Stofan, M., & Guo, G. L. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00544 · Cited by 214

Biliary Bicarbonate, pH, and Glucose Are Suitable Biomarkers of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers

Matton, A. P. M., de Vries, Y., Burlage, L. C., van Rijn, R., Fujiyoshi, M., de Meijer, V. E., de Boer, M. T., de Kleine, R. H. J., Verkade, H. J., Gouw, A. S. H., et al. (2018) · Transplantation · doi:10.1097/tp.0000000000002500 · Cited by 207

The Role of Fe, Zn, and Cu in Pregnancy

Grzeszczak, K., Kwiatkowski, S., & Kosik-Bogacka, D. I. (2020) · Biomolecules · doi:10.3390/biom10081176 · Cited by 206

Host-microbiome interactions: Gut-Liver axis and its connection with other organs

Anand, S., & Mande, S. S. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00352-6 · Cited by 201

The pathophysiology of intrahepatic cholestasis of pregnancy

Dixon, P. H., & Williamson, C. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.12.008 · Cited by 198

Intrahepatic Cholestasis of Pregnancy

Smith, D. D., & Rood, K. M. (2019) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000495 · Cited by 198

Physiology and Physical Chemistry of Bile Acids

di Gregorio, M. C., Cautela, J., & Galantini, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041780 · Cited by 197

Biliary bile acids in hepatobiliary injury – What is the link?

Fickert, P., & Wagner, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.04.026 · Cited by 192

Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions

Hrncir, T., Hrncirova, L., Kverka, M., Hromádka, R., Machova, V., Trckova, E., Kostovcikova, K., Králíčková, P., Krejsek, J., & Tlaskalová‐Hogenová, H. (2021) · Microorganisms · doi:10.3390/microorganisms9050957 · Cited by 183

Analytical methods for cholesterol quantification

Li, L., Dutkiewicz, E. P., Huang, Y.-C., Zhou, H.-B., & Hsu, C. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.09.001 · Cited by 179

Gut physiology and environment explain variations in human gut microbiome composition and metabolism

Procházková, N., Laursen, M. F., Barbera, G. L., Tsekitsidi, E., Jørgensen, M. S., Rasmussen, M. A., Raes, J., Licht, T. R., Dragsted, L. O., & Roager, H. M. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01856-x · Cited by 189

FXR in liver physiology: Multiple faces to regulate liver metabolism

Panzitt, K., & Wagner, M. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166133 · Cited by 170

Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

Lalor, R., Cwiklinski, K., Calvani, N. E. D., Dorey, A., Hamon, S., Corrales, J. L., Dalton, J. P., & Veríssimo, C. D. M. (2021) · Virulence · doi:10.1080/21505594.2021.1996520 · Cited by 163

Persistent organic pollutants in adipose tissue should be considered in obesity research

Lee, Y., Kim, K. S., Jacobs, D. R., & Lee, D. ‐. (2016) · Obesity Reviews · doi:10.1111/obr.12481 · Cited by 156

Enhancing Nutraceutical Performance Using Excipient Foods: Designing Food Structures and Compositions to Increase Bioavailability

McClements, D. J., Zou, L., Zhang, R., Salvia‐Trujillo, L., Kumosani, T., & Xiao, H. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12170 · Cited by 155

Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells

Ferraresso, F., Strilchuk, A. W., Juang, L. J., Poole, L. G., Luyendyk, J. P., & Kastrup, C. J. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00033 · Cited by 155

Food additives: Assessing the impact of exposure to permitted emulsifiers on bowel and metabolic health – introducing the FADiets study

Partridge, D., Lloyd, K., Rhodes, J. M., Walker, A. W., Johnstone, A. M., & Campbell, B. J. (2019) · Nutrition Bulletin · doi:10.1111/nbu.12408 · Cited by 154

Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis

Feng, Z., Hirai-Yuki, A., McKnight, K. L., & Lemon, S. M. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085359 · Cited by 152

Scientific Opinion on Dietary Reference Values for vitamin E as α‐tocopherol

EFSA Panel on Dietetic Products, N. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4149 · Cited by 148

Bile acid transporter-mediated oral drug delivery

Deng, F., & Bae, Y. H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.034 · Cited by 141

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z. V., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., Brabander, J. K. D., Elmquist, J. K., et al. (2017) · Science · doi:10.1126/science.aaf5375 · Cited by 133

Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics

Feldman, A. G., & Sokol, R. J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0132-z · Cited by 133

Review – An update on the use of oral phospholipid excipients

van Hoogevest, P. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.07.008 · Cited by 131

The role of bile acids in cholestatic liver injury

Cai, S., & Boyer, J. L. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5110 · Cited by 129

The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation

Beyer, D., Hoff, J., Sommerfeld, O., Zipprich, A., Gaßler, N., & Press, A. T. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00510-8 · Cited by 130

PPARs in liver physiology

Berthier, A., Johanns, M., Zummo, F. P., Lefebvre, P., & Staels, B. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166097 · Cited by 125

Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease

Jiao, T., Ma, Y., Guo, X., Ye, Y., & Xie, C. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00880-z · Cited by 122

Mechanisms of pruritus in cholestasis: understanding and treating the itch

Beuers, U. H., Wolters, F., & Elferink, R. P. J. O. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00687-7 · Cited by 122

Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

Masse, K. E., & Lu, V. B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1169624 · Cited by 120

Bile formation and secretion: An update

Boyer, J. L., & Soroka, C. J. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.02.011 · Cited by 118

Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity

Mercadante, C. J., Prajapati, M., Conboy, H. L., Dash, M. E., Herrera, C., Pettiglio, M. A., Cintrón-Rivera, L. G., Salesky, M., Rao, D. B., & Bartnikas, T. B. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129710 · Cited by 110

Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation

Mousa, O. Y. S., Juran, B. D., McCauley, B. M., Vesterhus, M. N., Folseraas, T., Turgeon, C. T., Ali, A. H., Schlicht, E. M., Atkinson, E. J., Hu, C., et al. (2020) · Hepatology · doi:10.1002/hep.31652 · Cited by 109

Neonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention

Feldman, A. G., & Sokol, R. J. (2021) · NeoReviews · doi:10.1542/neo.22-12-e819 · Cited by 105

Interactions between bile salts, gut microbiota, and hepatic innate immunity

Schubert, K. A., Damink, S. W. M. O., von Bergen�, M., & Schaap, F. G. (2017) · Immunological Reviews · doi:10.1111/imr.12579 · Cited by 104

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus

Hirai-Yuki, A., Hensley, L., Whitmire, J. K., & Lemon, S. M. (2016) · mBio · doi:10.1128/mbio.01998-16 · Cited by 102

Liver-Derived Exosomes and Their Implications in Liver Pathobiology

Sung, S., Kim, J., & Jung, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123715 · Cited by 101

Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats

Sun, J., Fan, J., Li, T., Yan, X., & Jiang, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04817 · Cited by 100

Normothermic machine perfusion of donor livers without the need for human blood products

Matton, A. P. M., Burlage, L. C., van Rijn, R., de Vries, Y., Karangwa, S. A., Nijsten, M. W., Gouw, A. S. H., Wiersema‐Buist, J., Adelmeijer, J., Westerkamp, A. C., et al. (2017) · Liver Transplantation · doi:10.1002/lt.25005 · Cited by 98

Molecular overview of progressive familial intrahepatic cholestasis

Amirneni, S., Haep, N., Gad, M. A., Soto–Gutiérrez, A., Squires, J. E., & Florentino, R. M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i47.7470 · Cited by 99

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Sticová, E., Jirsa, M., & Pawłowska, J. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/2313675 · Cited by 95

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders

Karpen, S. J., Kelly, D. A., Mack, C. L., & Stein, P. (2020) · Hepatology International · doi:10.1007/s12072-020-10070-w · Cited by 95

Synthesis of digestive enzymes, food processing, and nutrient absorption in decapod crustaceans: a comparison to the mammalian model of digestion

Vogt, G. (2021) · Zoology · doi:10.1016/j.zool.2021.125945 · Cited by 93

ABC transporters: human disease and pharmacotherapeutic potential

Moore, J. M., Bell, E. L., Hughes, R. O., & Garfield, A. S. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.11.001 · Cited by 94

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

Meyer, K., Ostrenko, O., Bourantas, G., Morales-Navarrete, H., Porat-Shliom, N., Segovia-Miranda, F., Nonaka, H., Ghaemi, A., Verbavatz, J.-M., Brusch, L., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2017.02.008 · Cited by 91

Pediatric Cholestatic Liver Disease: Review of Bile Acid Metabolism and Discussion of Current and Emerging Therapies

Kriegermeier, A. A., & Green, R. R. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00149 · Cited by 91

New insights on the role of vascular endothelial growth factor in biliary pathophysiology

Mariotti, V., Fiorotto, R., Cadamuro, M., Fabris, L., & Strazzabosco, M. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100251 · Cited by 88

Recent advances on FXR-targeting therapeutics

Panzitt, K., Zollner, G., Marschall, H., & Wagner, M. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111678 · Cited by 88

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease

Li, T., & Chiang, J. Y. L. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.09.03 · Cited by 87

Diagnostic considerations for cholestatic liver disease

Pollock, G., & Minuk, G. Y. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13738 · Cited by 88

Physiological functions of junctional adhesion molecules (JAMs) in tight junctions

Hartmann, C., Schwietzer, Y. A., Otani, T., Furuse, M., & Ebnet, K. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183299 · Cited by 84

Expanding etiology of progressive familial intrahepatic cholestasis

Henkel, S. A. F., Squires, J. H., Ayers, M., Ganoza, A., McKiernan, P. J., & Squires, J. E. (2019) · World Journal of Hepatology · doi:10.4254/wjh.v11.i5.450 · Cited by 83

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities

Vesterhus, M. N., & Karlsen, T. H. (2020) · Journal of Gastroenterology · doi:10.1007/s00535-020-01681-z · Cited by 85

Probiotication of Nutritious Fruit and Vegetable Juices: An Alternative to Dairy-Based Probiotic Functional Products

Mojikon, F. D., Kasimin, M. E., Molujin, A. M., Gansau, J. A., & Jawan, R. (2022) · Nutrients · doi:10.3390/nu14173457 · Cited by 81

A Bile Duct‐on‐a‐Chip With Organ‐Level Functions

Du, Y. M., Khandekar, G., Llewellyn, J., Polacheck, W. J., Chen, C. S., & Wells, R. G. (2019) · Hepatology · doi:10.1002/hep.30918 · Cited by 81

Molecular Regulation of Bile Acid Homeostasis

Choudhuri, S., & Klaassen, C. D. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000643 · Cited by 79

Structure of the human lipid exporter ABCB4 in a lipid environment

Olsen, J. A., Alam, A., Kowal, J., Stieger, B., & Locher, K. P. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0354-3 · Cited by 78

A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling

Shulpekova, Y. O., Shirokova, E. N., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., et al. (2022) · Molecules · doi:10.3390/molecules27061983 · Cited by 77

Human branching cholangiocyte organoids recapitulate functional bile duct formation

Roos, F. J. M., van Tienderen, G. S., Wu, H., Bordeu, I., Vinke, D., Albarinos, L. M., Monfils, K., Niesten, S., Smits, R., Willemse, J., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.04.011 · Cited by 76

Zebrafish as a Useful Model System for Human Liver Disease

Shimizu, N., Shiraishi, H., & Hanada, T. (2023) · Cells · doi:10.3390/cells12182246 · Cited by 75

RNA-Seq of Liver From Pigs Divergent in Feed Efficiency Highlights Shifts in Macronutrient Metabolism, Hepatic Growth and Immune Response

Horodyska, J., Hamill, R. M., Reyer, H., Trakooljul, N., Lawlor, P. G., McCormack, U. M. M., & Wimmers, K. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00117 · Cited by 74

Effect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid Model

Eilenberger, C., Rothbauer, M., Ehmoser, E.-K., Ertl, P., & Küpcü, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-41273-3 · Cited by 74

Physics of lumen growth

Dasgupta, S., Gupta, K., Zhang, Y., Viasnoff, V., & Prost, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722154115 · Cited by 74

Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension

Li, Q., Zhang, Y., Pluchon, P., Robens, J., Herr, K. J., Mercade, M., Thiery, J. P., Yu, H., & Viasnoff, V. (2016) · Nature Cell Biology · doi:10.1038/ncb3310 · Cited by 73

Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors

Stolz, A., Navarro, V. J., Hayashi, P. H., Fontana, R. J., Barnhart, H. X., Gu, J., Chalasani, N., Vega, M., Bonkovsky, H. L., Seeff, L. B., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15211 · Cited by 71

Cellular and organismal function of choline metabolism

Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 71

Interaction of divalent minerals with liposoluble nutrients and phytochemicals during digestion and influences on their bioavailability – a review

Corte‐Real, J., & Bohn, T. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.113 · Cited by 71

Influence of nanoparticles on liver tissue and hepatic functions: A review

Cornu, R., Béduneau, A., & Martin, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.152344 · Cited by 70

Role of enterohepatic recirculation in drug disposition: cooperation and complications

Malik, M. Y., Jaiswal, S., Sharma, A., Shukla, M. K., & Lal, J. (2016) · Drug Metabolism Reviews · doi:10.3109/03602532.2016.1157600 · Cited by 70

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

Sharanek, A., Burban, A., Humbert, L., Azzi, P. B.-E., Felix-Gomes, N., Rainteau, D. P., & Guillouzo, A. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv155 · Cited by 69

Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl− channels

Li, Q., Dutta, A. K., Kresge, C. K., Bugde, A., & Feranchak, A. P. (2018) · Hepatology · doi:10.1002/hep.29804 · Cited by 67

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin, H. K., Taylor, A. H., & Ayakannu, T. (2021) · Cancers · doi:10.3390/cancers13092149 · Cited by 65

Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice

Pradhan‐Sundd, T., Vats, R., Russell, J. O., Singh, S., Michael, A. A., Molina, L. M., Kakar, S., Cornuet, P. K., Poddar, M., Watkins, S. C., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.048 · Cited by 65

Advances on Vibrio parahaemolyticus research in the postgenomic era

Matsuda, S., Hiyoshi, H., Tandhavanant, S., & Kodama, T. (2019) · Microbiology and Immunology · doi:10.1111/1348-0421.12767 · Cited by 64

Gut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

Wang, Y., Gao, X., Zhang, X., Xiao, Y., Huang, J., Yu, D., Li, X., Hu, H., Ge, T., Li, D., et al. (2019) · mSystems · doi:10.1128/msystems.00463-19 · Cited by 64

Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice

Takahashi, S., Luo, Y., Ranjit, S., Xie, C., Libby, A. E., Orlicky, D. J., Dvornikov, A. S., Wang, X. X., Myakala, K., Jones, B. A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011913 · Cited by 64

Role of protein kinase C isoforms in bile formation and cholestasis

Anwer, S. M. (2014) · Hepatology · doi:10.1002/hep.27088 · Cited by 63

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice

Tanaka, H., Imasato, M., Yamazaki, Y., Matsumoto, K., Kunimoto, K., Delpierre, J., Meyer, K., Zerial, M., Kitamura, N., 渡辺, 光., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.08.025 · Cited by 63

Role of bile acids in the diagnosis and progression of liver cirrhosis: A prospective observational study

Liu, N., Feng, J., Lv, Y., Liu, Q., Deng, J., Xia, Y., Guo, C., & Zhou, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8011 · Cited by 63

A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids

Teng, Y., Zhao, Z., Tasnim, F., Huang, X., & Yu, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120904 · Cited by 62

Fibrotic Events in the Progression of Cholestatic Liver Disease

Wu, H., Chen, C., Ziani, S., Nelson, L. J., Avila, M. A., Nevzorova, Y. A., & Cubero, F. J. (2021) · Cells · doi:10.3390/cells10051107 · Cited by 62

State of the art in bile analysis in forensic toxicology

Bévalot, F., Cartiser, N., Bottinelli, C., Guitton, J., & Fanton, L. (2015) · Forensic Science International · doi:10.1016/j.forsciint.2015.10.034 · Cited by 62

Cellular Mechanisms of Hepatic Fluid and Electrolyte Transport

Dyke, R. W. V., Lake, J. R., & Scharschmidt, B. F. (1989) · Comprehensive physiology · doi:10.1002/j.2040-4603.1989.tb01392.x

THE MECHANISM OF BILIARY LIPID SECRETION AND ITS DEFECTS

Elferink, R. P. J. O., & Groen, A. K. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70043-1 · Cited by 27

Bile secretion

Erlinger, S. (1992) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072582 · Cited by 19

Cellular mechanisms of bile formation

Blitzer, B. L., & Boyer, J. L. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90027-0 · Cited by 140

Molecular Mechanisms in Bile Formation

Meier, P. J., & Stieger, B. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.2.89 · Cited by 51