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Cited by 898Drug Transport and Resistance MechanismsLiver physiology and pathologyIon Transport and Channel Regulation

The DOI matches its Crossref record; 595 of the 596 references it cites were found in a registry or an index, and 1 are not checked yet.

Bile Formation and Secretion

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Boyer, James L.·2013·Comprehensive Physiology
DOI 10.1002/j.2040-4603.2013.tb00519.x
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Abstract

Bile is a unique and vital aqueous secretion of the liver that is formed by the hepatocyte and modified down stream by absorptive and secretory properties of the bile duct epithelium. Approximately 5% of bile consists of organic and inorganic solutes of considerable complexity. The bile‐secretory unit consists of a canalicular network which is formed by the apical membrane of adjacent hepatocytes and sealed by tight junctions. The bile canaliculi (∼1 μm in diameter) conduct the flow of bile countercurrent to the direction of portal blood flow and connect with the canal of Hering and bile ducts which progressively increase in diameter and complexity prior to the entry of bile into the gallbladder, common bile duct, and intestine. Canalicular bile secretion is determined by both bile salt‐dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate‐binding cassette transport proteins that function as export pumps for bile salts and other organic solutes. These transporters create osmotic gradients within the bile canalicular lumen that provide the driving force for movement of fluid into the lumen via aquaporins. Species vary with respect to the relative amounts of bile salt‐dependent and independent canalicular flow and cholangiocyte secretion which is highly regulated by hormones, second messengers, and signal transduction pathways. Most determinants of bile secretion are now characterized at the molecular level in animal models and in man. Genetic mutations serve to illuminate many of their functions. © 2013 American Physiological Society. Compr Physiol 3:1035‐1078, 2013.

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Research works printed but not linked: 24

  1. 10.1002/hep.1840140413 · DOI
  2. Alvaro D, 1997, Role of kinases and phosphatases in the regulation of fluid secretion and C1−/HCO3 − exchange in cholangiocytes, Am J Physiol, 273, G303
  3. 10.1073/pnas.91.2.792 · DOI
  4. Bizard G, 1965, The Biliary System, 315
  5. Boyer JL, 1997, Bile Acids in Hepatobiliary Diseases: Basic Research and Clinical Application, 205
  6. Boyer JL, 1990, Methods in Enzymology, 517
  7. 10.1007/978-1-4613-2097-5_35 · DOI
  8. Bruck R, 1991, Exocytosis of horseradish peroxidase (HRP) is stimulated by protein kinase C (PKC) and inhibited by increased [Ca++]i in the isolated perfused rat liver (IPRL), Hepatology, 14, 148A
  9. Ekataksin W, 1997, Progress in Liver Diseases, 1
  10. Gautam A, 1986, Quantitative assessment of primary canalicular secretion in isolated rat hepatocyte couplets (IRHC) by optical planimetry, Gastroenterology, 90, 1727
  11. Hayakawa T, 1989, The protein kinase C agonist, 12,13 phorbol dibutyrate (PDB) counteracts cAMP‐stimulated horseradish peroxidase (HRP) excretion in the isolated perfused rat liver (IPRL), Hepatology, 10, 598
  12. 10.1002/hep.510230519 · DOI
  13. Lenzen R, 1990, Mechanisms of glucagon choleresis in the guinea pig, Am J Physiol, 259, G736
  14. 10.1016/s0026-895x(24)12069-x · DOI
  15. McCormick DB, 1994, The Liver: Biology and Pathobiology, 563
  16. Nathanson MH, 1994, The Liver: Biology and Pathobiology, 655
  17. Olson JR, 1980, Demonstration of a D‐glucose transport system in the biliary tract of the rat by use of the segmented retrograde intrabiliary injection technique, Biochem Pharmacol, 24, 263
  18. 10.1172/jci117658 · DOI
  19. Phillips MJ, 1986, Biology of disease mechanisms of cholestasis, Lab Invest, 54, 593
  20. Sirica AE, 1984, Isolation and partial characterization of oval and hyperplastic bile ductular cell‐enriched populations from the livers of carcinogen and noncarcinogen‐treated rats, Cancer Res, 44, 3454
  21. Sperber I, 1965, The Biliary System, 457
  22. 10.1002/hep.510250431 · DOI
  23. Trauner M, 1997, Endotoxin‐induced down‐regulation of the rat liver Na+/taurocholate cotransporter (ntcp) gene is mediated by decreased activity of hepatocyte nuclear factor 1 (HNF 1), Hepatology, 26, 262A
  24. Tuma PL, 2001, The Liver Biology and Pathbiology, 96

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Metadata

Authors
Boyer, J. L.
Affiliations
Yale University (US)
Corresponding author
Boyer, James L.
Venue
Comprehensive Physiology
Publisher
Wiley
Published
2013-07
Volume
3
Issue
3
Pages
1035-1078
ISSN
2040-4603 (ISSN-L)
DOI
10.1002/j.2040-4603.2013.tb00519.x
OpenAlex
W4409112708
Cited by
124
References
596
Citations by year
2026: 31 · 2025: 38 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
Comprehensive physiology (publishedVersion)
Funders
  • National Institutes of Health (DK25636)
  • U.S. Public Health Service (DK25636)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
bile formation, bile secretion, hepatocytes, bile canaliculi, ABC transporters, bile salt transport, cholangiocytes, bile duct epithelium, aquaporins, osmotic gradient

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