The DOI matches its Crossref record; 342 of the 342 references it cites were found in a registry or an index.
Hepatic Stellate Cells and Liver Fibrosis
Abstract
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the hepatic capsule. In normal adult liver, their most characteristic feature is the presence of cytoplasmic perinuclear droplets that are laden with retinyl (vitamin A) esters. Normal stellate cells display several patterns of intermediate filaments expression (e.g., desmin, vimentin, and/or glial fibrillary acidic protein) suggesting that there are subpopulations within this parental cell type. In the normal liver, stellate cells participate in retinoid storage, vasoregulation through endothelial cell interactions, extracellular matrix homeostasis, drug detoxification, immunotolerance, and possibly the preservation of hepatocyte mass through secretion of mitogens including hepatocyte growth factor. During liver injury, stellate cells activate into alpha smooth muscle actin‐expressing contractile myofibroblasts, which contribute to vascular distortion and increased vascular resistance, thereby promoting portal hypertension. Other features of stellate cell activation include mitogen‐mediated proliferation, increased fibrogenesis driven by connective tissue growth factor, and transforming growth factor beta 1, amplified inflammation and immunoregulation, and altered matrix degradation. Evolving areas of interest in stellate cell biology seek to understand mechanisms of their clearance during fibrosis resolution by either apoptosis, senescence, or reversion, and their contribution to hepatic stem cell amplification, regeneration, and hepatocellular cancer. © 2013 American Physiological Society. Compr Physiol 3:1473‐1492, 2013.
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“Activated HSCs overexpress tissue inhibitors of metalloproteinases (TIMPs), which inhibit key matrix-degrading enzymes (MMP-2, MMP-9, MMP-13), thereby preventing ECM degradation and promoting scar accumulation [35, 36].”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [36]
In the citing paper
“Sinusoidal dysfunction, including defenestration and HSC activation, precedes scar formation and liver fibrosis”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Puche et al., 2013
In the citing paper
“Fibrosis is regulated by an intricate interplay between TGF‐β pro‐fibrotic and TNF‐α anti‐fibrotic signaling pathways”
From p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling (2017) · cites this paper as Puche et al, 2013
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Metadata
- Authors
- Puche, J. E., Saiman, Y., & Friedman, S. L.
- Affiliations
- Universidad San Pablo CEU (ES)
- Mount Sinai Hospital (US)
- Corresponding author
- Friedman, Scott L.
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2013-10
- Volume
- 3
- Issue
- 4
- Pages
- 1473-1492
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W4409095387
- Cited by
- 89
- References
- 338
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 7 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Comprehensive physiology (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- hepatic stellate cells, liver fibrosis, stellate cell activation, alpha-smooth muscle actin, myofibroblasts, intermediate filaments, extracellular matrix homeostasis, connective tissue growth factor, TGF-β1, fibrosis resolution, hepatocyte growth factor, portal hypertension, liver regeneration, hepatocellular carcinoma, liver injury
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