The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Peripheral and Central Effects of Circulating Catecholamines
Open accessAbstract
Physical challenges, emotional arousal, increased physical activity, or changes in the environment can evoke stress, requiring altered activity of visceral organs, glands, and smooth muscles. These alterations are necessary for the organism to function appropriately under these abnormal conditions and to restore homeostasis. These changes in activity comprise the “fight‐or‐flight” response and must occur rapidly or the organism may not survive. The rapid responses are mediated primarily via the catecholamines, epinephrine, and norepinephrine, secreted from the adrenal medulla. The catecholamine neurohormones interact with adrenergic receptors present on cell membranes of all visceral organs and smooth muscles, leading to activation of signaling pathways and consequent alterations in organ function and smooth muscle tone. During the “fight‐or‐flight response,” the rise in circulating epinephrine and norepinephrine from the adrenal medulla and norepinephrine secreted from sympathetic nerve terminals cause increased blood pressure and cardiac output, relaxation of bronchial, intestinal and many other smooth muscles, mydriasis, and metabolic changes that increase levels of blood glucose and free fatty acids. Circulating catecholamines can also alter memory via effects on afferent sensory nerves impacting central nervous system function. While these rapid responses may be necessary for survival, sustained elevation of circulating catecholamines for prolonged periods of time can also produce pathological conditions, such as cardiac hypertrophy and heart failure, hypertension, and posttraumatic stress disorder. In this review, we discuss the present knowledge of the effects of circulating catecholamines on peripheral organs and tissues, as well as on memory in the brain. © 2015 American Physiological Society. Compr Physiol 5:1‐15, 2015.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The process of lipolysis is largely controlled via the endocrine system [12].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Training status has been shown to effect catecholamine release and receptor sensitivity [12], endogenous substrate concentrations, and cellular transport protein expression; all of which contribute to the variability of when MFO occurs relevant to exercise intensity [1].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As exercise intensity increases, so does catecholamine concentrations facilitating a concurrent increase of serum CHO and FAs into the blood [12].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Increased epinephrine concentrations that parallel increases in exercise intensity stimulate both glycogenolysis and gluconeogenesis [12].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The hormonal mechanisms that stimulate lipid metabolism are based primarily on catecholamines [12], cortisol, growth hormone, where insulin is inhibitory [16].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“Exercise intensity may further influence MFO by influencing catecholamine concentrations which have regulatory effects on lipolysis [16], glycogenolysis, as well as gluconeogenesis [12].”
From Understanding the factors that effect maximal fat oxidation. (2018) · cites this paper as [12]
In the citing paper
“The diabetogenic effect of GH is also validated by the high prevalence of diabetes in patients with acromegaly, a condition wherein the excessive growth hormones are produced citep (29).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [29]
In the citing paper
“GH has been characterized as one of the anti-insulin hormones.”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Goodman & Gilman's The Pharmacological Basis of Therapeutics
Brunton, L. L. (1985) · Cited by 7,321
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318
A STUDY OF THE ADRENOTROPIC RECEPTORS
Ahlquist, R. P. (1948) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1948.153.3.586 · Cited by 2,876
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · cited 2×
“Animal studies have provided further evidence that a subset of nuclei comprising the basolateral complex of the amygdala (BLA) is the major locus for receiving input mediating the stress response on memory (74,75).”
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777
Stress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760
LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402
Cited by
Sorted by citations
Items 401–479 of 479
LIMIAR GLICÊMICO INDIVIDUAL DE IDOSOS: IDENTIFICAÇÃO E CORRELAÇÃO
de Souza, W. C., Neto, D. L., de Melo, T. S., Oliveira, R. T., Barbosa, L. M., & dos Santos, Y. S. (2022) · Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida · doi:10.36692/v14n3-13
Chakroborty, D., & Sarkar, C. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_93
Kryuchkov, A. S., Михайлович, Ф. А., Missina, S. S., Dudko, G. A., & Борисович, М. Е. (2022) · Sports medicine research and practice · doi:10.47529/2223-2524.2022.3.3
Left ventricle mass index in paediatric intensive care unit acquired hypertension
Mekki, M., Algebaly, H. F., Sabry, H. A., Samir, M., & Rady, H. I. (2023) · Cardiology in the Young · doi:10.1017/s1047951123000781
Faqri, Musba, A. M. T., Amin, H., Arif, S. K., Salahuddin, A., & Wirawan, N. S. (2023) · Majalah Anestesia & Critical Care · doi:10.55497/majanestcricar.v41i2.282
Pierrieau, E. (2022) · Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)
Rôle des microARNs dans le contrôle de l'hypersécrétion par les tumeurs neuroendocrines.
Drissa, I. (2023) · theses.fr (ABES) · doi:10.70675/926a0c53z1252z4d63za9fcz204e10cfb66d
Arikawe, A. P., Oghene, O., Olusanya, A. W., Olumide, O., Dawodu, O. O., Babafemi, P., & Jaja, S. (2022) · African Journal of Endocrinology and Metabolism · doi:10.4103/ajem.ajem_2_23
Eid, A. A. E., Mostafa, T. A. H., Abdelrahman, R. S. S., & Elbadawy, A. H. (2024) · International Journal of Medical Anesthesiology · doi:10.33545/26643766.2024.v7.i2a.464
The Effect of Reflexology on Immunological Parameters of People Living with HIV
Nison, E., Turner, D., Ziv‐Baran, T., & Tau, L. (2024) · Integrative Medicine Reports · doi:10.1089/imr.2024.0011
A Harcolás, Menekülés, Lefagyás Kérdőív magyar változatának (FFFQ–HU) pszichometriai jellemzői
Kapitány‐Fövény, M., & Csigó, K. (2024) · Mentálhigiéné és Pszichoszomatika · doi:10.1556/0406.2024.00047
Organ of Zuckerkandl as a Source of Paraganglioma Pheochromocytoma
Varzhapetyan, A., Chitchyan, A., & Shahbazyan, S. (2024) · THE NEW ARMENIAN MEDICAL JOURNAL · doi:10.56936/18290825-18.2024-89
Kim, J. E., Sung, J.-A., Lim, S.-G., Park, Z.-U., Oh, T., & Min, S. (2024) · 한국생활환경학회지 · doi:10.21086/ksles.2024.12.31.6.493
Oyerinde, T. O., Anadu, V. E., Olajide, T. S., Ijomone, O. K., Okeowo, O. M., & Ijomone, O. M. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.001
Stress, Immunity, and Personality
Padmakumari, P., & Alexander, A. E. (2025) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-7432-0.ch004
The Complexities of Metabolic Flexibility and Precision Approaches to Sustainable Weight Management
Theodorakis, N., Kreouzi, M., Pappas, A., Feretzakis, G., Sakagianni, A., Kalodanis, K., Αναστασίου, Α., Nikolaou, M., & Koumpouros, Y. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5787-3.ch005 · Cited by 1
The Psychobiology of Life Stress Events and Disease
Biondi, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-87144-3_5
Nordine, M., Kagelmann, N., Kloka, J. A., Gunga, H., Heinz, V., Pilz, N., Opatz, O. S., & Bothe, T. L. (2025) · npj Microgravity · doi:10.1038/s41526-025-00486-9
Luo, J., Zhao, X., Xiao, M., Deng, J., Xie, S., Fan, H., Lu, W., Su, Y., Wu, T., Ma, H., et al. (2025) · Translational Stroke Research · doi:10.1007/s12975-025-01372-y
Lee, W., Kim, A.-R., Chang, J., & Lee, H.-S. (2025) · Exercise Science · doi:10.15857/ksep.2025.00311
Fokin, V. F., Абаимов, Д. А., Ponomareva, N. V., Medvedev, R., Коновалов, Р. Н., Лагода, О. В., Krotenkova, M., Shabalina, A., & Tanashyan, M. М. (2025) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2025.038
Fokin, V. F., Абаимов, Д. А., Пономарева, Н. В., Medvedev, R. B., Коновалов, Р. Н., Лагода, О. В., Кротенкова, М. В., Шабалина, А. А., & Танашян, М. М. (2025) · Вестник Российского государственного медицинского университета · doi:10.24075/vrgmu.2025.038
Munhoz, J., Oliveira, A., Azevedo, M., Seixas, R., Moreira-Rodrigues, M., Serrão, P., & Moreira-Rodrigues, M. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123946
Kamil, W., Pstras, L., Białończyk, U., Dębowska, M., Dąbrowski, W., Siwicka-Gieroba, D., & Poleszczuk, J. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013501
The Adrenal Medulla and Integration of Metabolic Control
Feher, J. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-820476-4.00079-5
Decoding dog communication through the physiology and behavior of urine marking
Quaranta, A., d’Ingeo, S., Minunno, M., Straziota, V., Nolè, M., Ventriglia, G., Ceci, E., & Siniscalchi, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-31373-8
Treatment During Abstinence from Methamphetamine in a Rat Model of Methamphetamine Use Disorder
Baek, J. J. (2022) · Purdue University Indianapolis (Indiana University) · doi:10.7912/c2/3068
Jung, S. (2023) · Maryland Shared Open Access Repository (USMAI Consortium) · doi:10.13016/m2lxw6-ob3q
Klinger, M. (2024) · eScholarship (California Digital Library)
Association Between Use of Remdesivir and Bradycardia
Umeukeje, G. (2022) · Digital Commons - University of South Florida (University of South Florida)
The impact of trait anxiety and psychosocial stress on sympathetic neural control in humans
Bigalke, J. A. (2023) · Montana State University ScholarWorks (Montana State University)
Adrenergic signalling in ageing: Role of tyramine and octopamine in Drosophila
Sumit, A. F. (2025) · UCL Discovery (University College London)
Howell, A. (2021) · HARVEST (University of Saskatchewan)
The Relationship of Divine Forgiveness, Victim Forgiveness, and Physical Health Mediated by Stress
Ragasajo, L. J. C. (2021) · Digital Commons (Liberty University)
Meesmann, A., Sager, H., & München, T. U. (2022) · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Thela, L. T. (2022) · Open University of Cape Town (University of Cape Town)
Zhang, J. M., Yuan, X., Ding, H., Chen, X., & Jiang, C. (2026) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2026.9610039
Gavini, C. K., Labouèbe, G., Gorostidi, F., & Mansuy‐Aubert, V. (2026) · iScience · doi:10.1016/j.isci.2026.115446
The Role of Exercise in Fat Oxidation and Its Impact on Adolescent Metabolism
Engin, A., & Engin, A. B. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-7000-3_17
Tan, Z., Wang, T., He, W., Weng, Z., Xie, K., Chen, Z., Shen, X., & Wang, D. (2026) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575419669260114072747
Sosner, P. (2016) · theses.fr (ABES) · doi:10.70675/9ecbe77bz7010z478az871eze93a2a11acde
Study of the role of the lateral habenula in fear conditioning and stress response in rat
Durieux, L. (2021) · theses.fr (ABES) · doi:10.70675/6aef2b06ze4d6z47dezbb31z9f954c98768d
Impact of psychological stress on the remodeling of the host-microbiota interactome
Zoppi, J. (2021) · theses.fr (ABES) · doi:10.70675/99fe295fzda6cz4938z9de2zedddc5a8bbd8
Streit, L. (2021) · theses.fr (ABES) · doi:10.70675/3269cd86zf5cez4e27z8df0zbfdff2079072
Involvement of beta1-adrenergic modulation on lymphocyte balance during experimental septic shock
Durand, M. (2021) · theses.fr (ABES) · doi:10.70675/2351c82ezd964z40edz8084z776fd97e6480
Etude expérimentale de l’hémodynamique cérébrale au cours de la prise en charge d’un arrêt cardiaque
Levy, Y. A. (2023) · theses.fr (ABES) · doi:10.70675/a2ef3a75z2507z49c7zad13ze8fa83e16af5
Médecine d’urgence, nutrition et biomarqueurs du stress
Bouillon‐Minois, J. (2022) · theses.fr (ABES) · doi:10.70675/9293ae03ze761z4582zb5f5z9ecb1a766db9
Impact des catécholamines sur la progression tumorale des carcinomes hépatocellulaires
Lelou, E. (2022) · theses.fr (ABES) · doi:10.70675/3dc070faz133az4982z9e69z37b1c3d81284
Involvement of a ventral tegmental area-Amygdala pathway in anxiety and fear
Contesse, T. (2022) · theses.fr (ABES) · doi:10.70675/16b29ac5zdda6z4ec8z9bafzc3d3a021d97f
Kylančios aortos ir aortos lanko vidinės inervacijos tyrimas
Toumanov, Y. (2023) · Lithuanian University of Health Sciences
Drossart, T. (2025) · theses.fr (ABES) · doi:10.70675/3d7ac8c8z01e3z43b5z8286ze5ede0f2dec4
Hagimont, E. (2024) · theses.fr (ABES) · doi:10.70675/01900058z34f3z479fzb3d5z4df1c810d682
Alam, M. J., Wang, K., Zhao, T., Li, F., & Chen, J. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106298
Seeley, A. D., Mayer, T. A., Alba, B. K., Bodurtha, P. O., Bradbury, K. E., Brazelton, S. C., Caldwell, A. R., Connor, K. R., Giersch, G. E. W., Goldenstein, S. J., et al. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00149.2025
Molecular mechanisms of stress-induced changes in metabolism and neuroregulation
Karabanov, S. Y., Fedulova, L. R., Vasilevskaya, E., & Kibitkina, A. A. (2026) · Genes and Cells · doi:10.17816/gc699058
Communication in the Depressed Brain
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_7
Podjava, A., & Šilaks, A. (2026) · Separations · doi:10.3390/separations13060182
Stem cells of the hypothalamic-pituitary-adrenal axis
Sherwin, O., Basham, K. J., & Andoniadou, C. L. (2026) · Endocrine Reviews · doi:10.1210/endrev/bnag024
The α2A-adrenergic receptor on Tfh cells amplifies allergic airway inflammation via Akt signaling
Lan, G., Du, J., Chen, J., Xie, S., Lai, X., Zhao, Y., Liu, Y., Huang, C., Du, X., Sun, Y., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10670-6
Trait Resilience Modulates the Association Between Cortisol and Aperiodic Neural DynamicsPreprint
Lee, K. F. A., Asharaf, S. T., Liang, L., & Lee, T. M. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.09.737399
Sarkar, S., Nath, A., Chakraborty, S., Chattopadhyay, A., Islam, S., Das, A. R., & Bandyopadhyay, D. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110464
Monoamine Neurotransmitters in Saliva: Novel Biomarkers of CNS Function and Therapeutic Response?
Bleibel, L., Altabbouche, R., Vuksan, B., Hassan, A. S., & Karbownik, M. S. (2026) · Neuropsychobiology · doi:10.1159/000553317
Signal Transduction and Drugs that Target Signaling Pathways
Minden, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-20529-2_18
Monaghan, K. (2026) · Iowa Research Online (The University of Iowa) · doi:10.25820/etd.008366
Lee, K. F. A., Liang, L., Asharaf, S. T., & Lee, T. M. C. (2026) · iScience · doi:10.1016/j.isci.2026.116936
Braunsperger, A., Tischer, D., Soriano‐Arroquia, A., Schönfelder, M., Georgiadi, A., & Wackerhage, H. (2026) · Sports Medicine - Open · doi:10.1186/s40798-026-01085-y
Khodaparast, M., Dastgheib, S. A., Mansoori, Y., Goodarzi, H., & Forouzanfar, M. (2026) · International Journal of Cancer Management · doi:10.5812/ijcm-160537
Yaglova, N. V., Tutelyan, V. A., Tarmaeva, I. Y., Obernikhin, S. S., & Nikityuk, D. B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188323
O’Leary, E. M., Eggleston, R. L., Meling, D. D., Usman, A.-F., Rahman, S. J., Tamas, A. L., Huang, T., Sands, M., Irudayaraj, J., & Bonthuis, P. J. (2026) · Genetics · doi:10.1093/genetics/iyag256
Zhang, J., 朱洪玉, Wang, W., Shen, B., Xin, Y., Song, X., Lu, X., Li, L., Chen, S., Zhang, X., et al. (2026) · Advanced Science · doi:10.1002/advs.202518996
Soucy, J. R., & Koppes, R. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-16110-0.00002-9
Villagrán, M., Echaides, C., Seltmann, M. W., Šlipogor, V., Esattore, B., Saggiomo, L., & Damián, J. P. (2026) · Royal Society Open Science · doi:10.1098/rsos.260738
Morrow, E., Brown, K. D., katerman, B., Sumner, J. A., & Clewett, D. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101403
Metadata
- Authors
- William Tank, A., & Lee Wong, D.
- Affiliations
- Department of Pharmacology & Physiology University of Rochester Medical Center Rochester NY USA
- Department of Psychiatry Harvard Medical School, McLean Hospital Belmont MA USA
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 5
- Issue
- 1
- Pages
- 1-15
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W4409092676
- Cited by
- 106
- References
- 134
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 2
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Comprehensive physiology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- circulating catecholamines, epinephrine, norepinephrine, fight-or-flight response, stress response, adrenergic receptors, smooth muscle relaxation, blood pressure, cardiac output, memory, cardiac hypertrophy, heart failure, hypertension, post-traumatic stress disorder, adrenal medulla, sympathetic nerve terminals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
