The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Review: Toxicometabolomics
Open accessAbstract
Metabolomics use in toxicology is rapidly increasing, particularly owing to advances in mass spectroscopy, which is widely used in the life sciences for phenotyping disease states. Toxicology has the advantage of having the disease agent, the toxicant, available for experimental induction of metabolomics changes monitored over time and dose. This review summarizes the different technologies employed and gives examples of their use in various areas of toxicology. A prominent use of metabolomics is the identification of signatures of toxicity – patterns of metabolite changes predictive of a hazard manifestation. Increasingly, such signatures indicative of a certain hazard manifestation are identified, suggesting that certain modes of action result in specific derangements of the metabolism. This might enable the deduction of underlying pathways of toxicity, which, in their entirety, form the Human Toxome, a key concept for implementing the vision of Toxicity Testing for the 21st century. This review summarizes the current state of metabolomics technologies and principles, their uses in toxicology and gives a thorough overview on metabolomics bioinformatics, pathway identification and quality assurance. In addition, this review lays out the prospects for further metabolomics application also in a regulatory context. Copyright © 2013 John Wiley & Sons, Ltd.
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PLS-regression: a basic tool of chemometrics
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A Modular Approach to the ECVAM Principles on Test Validity
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bioinformatics tools for mass spectroscopy-based metabolomic data processing and analysis
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Sturla, S. J., Boobis, A. R., FitzGerald, R. E., Hoeng, J., Kavlock, R. J., Schirmer, K., Whelan, M., Wilks, M. F., & Peitsch, M. C. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400410s · Cited by 366
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
Ramirez, T., Strigun, A., Verlohner, A., Huener, H.-A., Peter, E., Herold, M., Bordag, N., Mellert, W., Walk, T., Spitzer, M., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2079-6 · Cited by 164
Good Cell Culture Practice for stem cells and stem-cell-derived models
Pamies, D. (2016) · ALTEX · doi:10.14573/altex.1607121 · Cited by 160
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Self-citation
Metadata
- Authors
- Bouhifd, M., Hartung, T., Hogberg, H. T., Kleensang, A., & Zhao, L.
- Venue
- Journal of Applied Toxicology
- Publisher
- Wiley
- Published
- 2013-05-30
- Volume
- 33
- Issue
- 12
- Pages
- 1365-1383
- ISSN
- 0260-437X (ISSN-L)
- 1099-1263
- OpenAlex
- W2313903357
- Cited by
- 187
- References
- 8
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- green
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