The Human Toxome Project

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Integration of biological networks and gene expression data using Cytoscape

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METLIN—a metabolite mass spectral database

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Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

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Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

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Toxicity testing in the 21st century: A vision and a strategy

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Toxicology for the twenty-first century

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The different roles of ER subtypes in cancer biology and therapy

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Transforming Environmental Health Protection

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In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

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Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

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“ToxRTool”, a new tool to assess the reliability of toxicological data

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Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ

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Guidance on Good Cell Culture Practice: A Report of the Second ECVAM Task Force on Good Cell Culture Practice

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General, Applied and Systems Toxicology

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A Modular Approach to the ECVAM Principles on Test Validity

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Toxicity Testing in the 21st Century: Bringing the Vision to Life

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Rapid screening of environmental chemicals for estrogen receptor binding capacity.

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Toxicogenomics in Regulatory Ecotoxicology

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Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

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Chemical regulators have overreached

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MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity

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Event extraction for systems biology by text mining the literature

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A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

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High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project

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Metabolomics in toxicology and preclinical research

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Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

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Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment

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Look back in anger – what clinical studies tell us about preclinical work

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Are In Vitro Tests Suitable for Regulatory Use?

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Rapid yeast estrogen bioassays stably expressing human estrogen receptors α and β, and green fluorescent protein: a comparison of different compounds with both receptor types

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Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes

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Review: Toxicometabolomics

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Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

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Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

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Consensus report on the future of animal-free systemic toxicity testing

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Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats

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Integrated testing strategies (ITS) for safety assessment

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Integrated testing strategies for safety assessments

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Toxicity testing: Strategies to determine needs and priorities

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Toxicity Testing. Strategies to Determine Needs and Priorities

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Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Receptor-α–Positive and –Negative Breast Cancer Cells

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Toward an evidence-based toxicology

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On mapping the human toxome

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Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

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Implementing Toxicity Testing in the 21st Century (TT21C): making safety decisions using toxicity pathways, and progress in a prototype risk assessment

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The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

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Food for thought … on in silico methods in toxicology

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ECVAM Good Cell Culture Practice Task Force Report 1

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A Toxicology for the 21st Century—Mapping the Road Ahead

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A map of the PPARα transcription regulatory network for primary human hepatocytes

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Validation and quality control of replacement alternatives - current status and future challenges

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Food for thought ... on animal tests

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The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

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Development of a rapid yeast estrogen bioassay, based on the expression of green fluorescent protein

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Pathways of Toxicity

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Food for thought ... on cell culture

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Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century

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Systems toxicology

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From alternative methods to a new toxicology

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A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

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Food for Thought … Mechanistic Validation

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Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

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Guidance on Good Cell Culture Practice

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Toxicity Testing in the 21st Century

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Diagnosis: Toxic! – Trying to Apply Approaches of Clinical Diagnostics and Prevalence in Toxicology Considerations

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Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM–ICCVAM/NICEATM Considerations for Regulatory Use

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Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses

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Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

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Evidence-based toxicology – the toolbox of validation for the 21st century?

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Big biology: The ’omes puzzle

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Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing

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GEMS (Gene Expression Metasignatures), a Web Resource for Querying Meta-analysis of Expression Microarray Datasets: 17β-Estradiol in MCF-7 Cells

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Integromic Analysis of the NCI-60 Cancer Cell Lines

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An integrated functional genomic study of acute phenobarbital exposure in the rat

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Toxicogenomics: Overview and potential applications for the study of non-covalent DNA interacting chemicals

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Insights into significant pathways and gene interaction networks underlying breast cancer cell line MCF-7 treated with 17β-Estradiol (E2)

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A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

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Food for thought … on evidence-based toxicology

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Probabilistic approach to detecting dependencies between data sets

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The Principles of Good Laboratory Practice: Application to In Vitro Toxicology Studies

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Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

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Evidence-based toxicology for the 21st century: Opportunities and challenges

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In Vitro Models in Endocrine Disruptor Screening

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Toxicology ontology perspectives

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Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects

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Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

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A Rapid and Sensitive Reporter Gene that Uses Green Fluorescent Protein Expression to Detect Chemicals with Estrogenic Activity

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Points of Reference in the Validation Process

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Interplay of estrogen receptors and GPR30 for the regulation of early membrane initiated transcriptional effects: A pharmacological approach

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Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

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A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids

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Gene Expression Analysis of the Hepatotoxicant Methapyrilene in Primary Rat Hepatocytes: An Interlaboratory Study

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Food for thought ... on globalisation of alternative methods

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Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program

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A toxicology ontology roadmap

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Applications of Emerging Technologies in Toxicology and Safety Assessment

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Food for Thought … Systems Toxicology

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Optimisation of the Post-validation Process

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LIFE SCIENCE TECHNOLOGIES: Animal-Free Toxicology: Sometimes, in Vitro is Better

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Learning from microarray interlaboratory studies: measures of precision for gene expression

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