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Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns
Abstract
The preparation of block polymer surface‐active agents derived solely from propylene oxide and ethylene oxide is described. The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F‐127, are presented. The toxicity data of the polymeric series is reviewed. The preparation of cold aqueous solutions of the F‐127 solution, to which silver salts and other medicaments are then added, is described. By raising the temperature, these fluid liquids are then converted to strong “ringing” gels or viscous ointments which are suitable for application to a burn wound or abraded skin area. The factors involved in altering the yield strength of the gel are presented.
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Citations
Cites
Organ perfusion and preservation
Norman, J. C. (1968) · Appleton-Century-Crofts eBooks · Cited by 310
Cited by
Thermoresponsive hydrogels in biomedical applications
Klouda, L., & Mikos, A. G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.02.025 · Cited by 1,349
In situ-forming hydrogels--review of temperature-sensitive systems
Ruel-Gariépy, E., & Leroux, J.-C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.019 · Cited by 1,297
Chiappetta, D. A., & Sosnik, A. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.03.022 · Cited by 567
Injectable gels for tissue engineering
Gutowska, A., Jeong, B., & Jasionowski, M. (2001) · The Anatomical Record · doi:10.1002/ar.1115 · Cited by 441
Poloxamer: A versatile tri-block copolymer for biomedical applications
Zarrintaj, P., Ramsey, J. D., Samadi, A., Atoufi, Z., Yazdi, M. K., Ganjali, M. R., Amirabad, L. M., Zangene, E., Farokhi, M., Formela, K., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.04.028 · Cited by 404
Metadata
- Authors
- Schmolka, I. R.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1972-11
- Volume
- 6
- Issue
- 6
- Pages
- 571-582
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2058509094
- Cited by
- 894
- References
- 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schmolka, I. R. (1972). Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820060609
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.