Cited by 1,297Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsPolysaccharides Composition and Applications

In situ-forming hydrogels--review of temperature-sensitive systems

Ruel-Gariépy, Eve, Leroux, Jean-Christophe·2004·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The thermosensitive approach can be advantageous for particular applications as it does not require organic solvents, co-polymerization agents, or an externally applied trigger for gelation. In the last 2 decades, several thermosensitive formulations have been proposed. This manuscript focuses on aqueous polymeric solutions that form implants in situ in response to temperature change, generally from ambient to body temperature. It mainly reviews the characterization and use of polysaccharides, N-isopropylacrylamide copolymers, poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (poloxamer) and its copolymers, poly(ethylene oxide)/(D,L-lactic acid-co-glycolic acid) copolymers, and thermosensitive liposome-based systems.

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Crossref · 10.1016/j.ejpb.2004.03.019

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Authors
Ruel-Gariépy, E., & Leroux, J.-C.
Affiliations
Université de Montréal (CA)
Corresponding author
Leroux, Jean-Christophe
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2004-09
Volume
58
Issue
2
Pages
409-426
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2094505929
Cited by
1,297
References
116
Citations by year
2026: 54 · 2025: 41 · 2024: 50 · 2023: 51 · 2022: 57 · 2021: 70 · 2020: 53 · 2019: 68 · 2018: 82 · 2017: 75 · 2016: 69 · 2015: 80 · 2014: 77 · 2013: 66 · 2012: 92
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
in situ forming hydrogels, thermosensitive hydrogel, polysaccharides, N-isopropylacrylamide copolymers, poloxamer, thermosensitive liposomes, drug delivery, cell encapsulation, tissue repair, pH-responsive gels
MeSH terms
Animals, Body Temperature, Drug Carriers, Humans, Liposomes, Polymers, Polysaccharides, Temperature, Drug Delivery Systems, Hydrogels

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