In situ-forming hydrogels--review of temperature-sensitive systems
Abstract
In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The thermosensitive approach can be advantageous for particular applications as it does not require organic solvents, co-polymerization agents, or an externally applied trigger for gelation. In the last 2 decades, several thermosensitive formulations have been proposed. This manuscript focuses on aqueous polymeric solutions that form implants in situ in response to temperature change, generally from ambient to body temperature. It mainly reviews the characterization and use of polysaccharides, N-isopropylacrylamide copolymers, poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (poloxamer) and its copolymers, poly(ethylene oxide)/(D,L-lactic acid-co-glycolic acid) copolymers, and thermosensitive liposome-based systems.
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Some thermoresponsive polymers are capable of forming hydrogel near body temperature.
“some thermoresponsive polymers are capable of forming hydrogel near body temperature [33,34].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [33]
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- Authors
- Ruel-Gariépy, E., & Leroux, J.-C.
- Affiliations
- Université de Montréal (CA)
- Corresponding author
- Leroux, Jean-Christophe
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 58
- Issue
- 2
- Pages
- 409-426
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2094505929
- Cited by
- 1,297
- References
- 116
- Citations by year
- 2026: 54 · 2025: 41 · 2024: 50 · 2023: 51 · 2022: 57 · 2021: 70 · 2020: 53 · 2019: 68 · 2018: 82 · 2017: 75 · 2016: 69 · 2015: 80 · 2014: 77 · 2013: 66 · 2012: 92
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- in situ forming hydrogels, thermosensitive hydrogel, polysaccharides, N-isopropylacrylamide copolymers, poloxamer, thermosensitive liposomes, drug delivery, cell encapsulation, tissue repair, pH-responsive gels
- MeSH terms
- Animals, Body Temperature, Drug Carriers, Humans, Liposomes, Polymers, Polysaccharides, Temperature, Drug Delivery Systems, Hydrogels
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