The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bioabsorption of polylactides with different molecular properties
Abstract
In order to study the effects of factors governing the bioabsorption rate of polylactides, implantation tests were carried out in rabbits using various samples (20 × 10 × 2 mm 3) differing in their chemical composition, residual monomer content, and molecular orientation. Copolymer samples with a higher lactic acid content showed a lower rate of absorption, whereas those with a higher unreacted monomer content were absorbed faster and showed a more drastic decrease in molecular weight. In contrast, degradation of the purified polymers was slow; the purified poly‐L‐lactide showed no weight change and a 50% reduction in molecular weight after 6 months of implantation. Scanning electron microscopy of the samples containing monomers showed a microporous structure extending from the surface to the inner region a few days after implantation, whereas the purified poly‐L‐lactide did not exhibit a microporous structural change even after 10 months of implantation.
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Cites
Miller, R. A., Brady, J. M., & Cutright, D. E. (1977) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820110507 · Cited by 722
In vivo biocompatibility studies. I. The cage implant system and a biodegradable hydrogel
Marchant, R., Hiltner, A., Hamlin, C., Rabinovitch, A., Slobodkin, R., & Anderson, J. M. (1983) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820170209 · Cited by 181
Cited by
Li, S. M., Garreau, H., & Vert, M. (1990) · Journal of Materials Science: Materials in Medicine · doi:10.1007/bf00700871 · Cited by 733
Alexis, F. (2005) · Polymer International · doi:10.1002/pi.1697 · Cited by 443
Applications of Polymer Nanofibers in Biomedicine and Biotechnology
Venugopal, J., & Ramakrishna, S. (2005) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:125:3:147 · Cited by 370
Tsuji, H., & Ikada, Y. (2000) · Polymer Degradation and Stability · doi:10.1016/s0141-3910(99)00111-1 · Cited by 329
Self-citationMore about the degradation of LA/GA-derived matrices in aqueous media
Vert, M., Li, S., & Garreau, H. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90027-b · Cited by 295
Metadata
- Authors
- Nakamura, T., Hitomi, S., Watanabe, S., Shimizu, Y., Jamshidi, K., Hyon, S. ‐., & Ikada, Y.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1989-10
- Volume
- 23
- Issue
- 10
- Pages
- 1115-1130
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2033121543
- Cited by
- 241
- References
- 2
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nakamura, T., Hitomi, S., Watanabe, S., Shimizu, Y., Jamshidi, K., Hyon, S. ‐., & Ikada, Y. (1989). Bioabsorption of polylactides with different molecular properties. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820231003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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