Cited by 62Silk-based biomaterials and applicationsCollagen: Extraction and CharacterizationHydrogels: synthesis, properties, applications

Applications and degradation of proteins used as tissue engineering materials

Open access
Wang, Hua-Jie, Di, Ling, Ren, Qiu-Shi, Wang, Jin-Ye·2009·Materials

Abstract

This article provides an up-to-date review on the applications of natural polymers, i.e., proteins, as materials for tissue engineering. Proteins are one of the important candidates for tissue engineering materials based on their superior biocompatibility, biodegradation, bioresorbability, and so on. However, their inferior mechanical properties limit their broad application. Currently-available proteins for application in tissue engineering or drug delivery systems, such as fibrin, collagen, zein, silk fibroin, keratin, casein and albumin, and the biodegradation of tissue-engineered substitutes based on proteins are presented. Techniques of scaffold fabrication are also mentioned. Problems and future possibilities for development of protein-based tissue-engineered substitutes are also introduced in this review.

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  • When silk fibroin is degraded, the resulting amino acids can be taken up outside the body without significant toxicity to cells.

    “When silk fibroin is degraded, the resulting amino acids can be taken up outside the body without significant toxicity to the cells [29], a property that is favorable for biomedical applications.”

    From Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review (2025) · cites this paper as [29]

    The Introduction (page unavailable) says protein degradation produces amino acids that can be resorbed as nutrients, and §2.4 describes silk fibroin as biocompatible and biodegradable. Neither passage establishes that amino acids from degraded silk fibroin are taken up outside the body without significant toxicity to cells. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. [71]Deutsch M. Meinhart J. Zilla P. Howanietz N. Gorlitzer M. Froeschl A. Stuempflen A. Bezuidenhout D. Grabenwoeger M. Long-term experience in autologous in vitro endothelialization of infrainguinal ePTFE grafts J. Vasc. Surg. 2009 49 352 362 10.1016/j.jvs.2008.08.101 19110397 · DOI
  2. [121]Quaglia F. Bioinspired tissue engineering: the great promise of protein delivery technologies Int. J. Pharm. 2008 364 281 297 10.1016/j.ijpharm.2008.04.030 18538517 · DOI

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Authors
Wang, H.-J., Di, L., Ren, Q.-S., & Wang, J.-Y.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Biomedical Engineering, School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Corresponding author
Wang, Jin-Ye
Venue
Materials
Publisher
MDPI AG
Published
2009-05-26
Volume
2
Issue
2
Pages
613-635
ISSN
1996-1944 (ISSN-L)
OpenAlex
W2044067048
Cited by
62
References
146
Citations by year
2026: 1 · 2025: 6 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
0.15
Type
journal article
Language
en
Open access
Locations
  • Materials (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
protein-based biomaterials, tissue engineering scaffolds, biodegradation, biocompatibility, fibrin, collagen, zein, silk fibroin, keratin, casein, albumin, drug delivery systems, scaffold fabrication, protein mechanical properties

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