Polyvinylidene fluoride (PVDF) as a biomaterial: From polymeric raw material to monofilament vascular suture
Abstract
This study identified the effects of various manufacturing processes on the crystalline microstructure, mechanical properties, and biocompatibility of a polyvinylidene fluoride (PVDF) suture. To achieve this, changes in the crystalline microstructure and the tensile behavior of PVDF monofilaments were monitored in vitro after different thermal processing, coloration, and sterilization treatments. In addition, the in vivo biocompatibility of the manufactured and sterilized PVDF suture was assessed by using it to anastomose a preclotted polyester vascular prosthesis as a thoracoabdominal bypass in a series of dogs. The tissue response was followed by histologic and scanning electron microscopy over implantation periods ranging from 4 h to 6 months. Differential scanning calorimetry and infrared spectroscopy (FTIR‐ATR) showed that thermal processing and the addition of a coloring agent had a direct effect on modifying the crystalline microstructure and hence changing the mechanical properties. For example, thermal processing converted some of the α phase into the β and γ polymorphs, whereas coloration led only to a major increase in the β‐to‐α ratio. The tensile properties were found to be optimized when the relative proportion of the β and γ phases combined compared to the α form gave rise to an FTIR A509/A532 absorption ratio between 4.0 and 4.5. Sterilization was found to cause some modifications to the crystalline microstructure near the surface of the monofilaments, but it did not change their mechanical properties. Pathologic examination of the anastomotic regions after different periods of implantation revealed a minimal cellular response, with no mineralization, intimal hyperplasia, or excessive fibrous tissue reaction. This good biocompatibility, together with other desirable characteristics such as ease of manipulation and satisfactory mechanical strength, makes PVDF an attractive alternative monofilament suture material for cardiovascular surgery. © 1995 John Wiley & Sons, Inc.
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Unpatterned PVDF is not stretchable because its Young's modulus is 3.6 GPa.
“Its Young's modulus is 3.6 GPa hence unpatterned PVDF is not stretchable either.17, 18”
From A Chest‐Laminated Ultrathin and Stretchable E‐Tattoo for the Measurement of Electrocardiogram, Seismocardiogram, and Cardiac Time Intervals (2019) · cites this paper as [18]
PVDF is a commercially available piezoelectric polymer that is mechanically robust and biocompatible.
“In contrast, polyvinylidene fluoride (PVDF) is a commercially available piezoelectric polymer that is mechanically robust and biocompatible.”
From A Chest‐Laminated Ultrathin and Stretchable E‐Tattoo for the Measurement of Electrocardiogram, Seismocardiogram, and Cardiac Time Intervals (2019) · cites this paper as [18]
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Ha, T., Tran, J., Liu, S., Jang, H., Jeong, H., Mitbander, R., Huh, H., Qiu, Y., Duong, J., Wang, R. L., et al. (2019) · Advanced Science · doi:10.1002/advs.201900290 · Cited by 220 · see citing works
- Authors
- Laroche, G., Marois, Y., Guidoin, R., King, M. W., Martin, L., How, T., & Douville, Y.
- Affiliations
- Hôpital du Saint-Sacrement (CA)
- University of Liverpool (GB)
- Corresponding author
- Guidoin, Robert
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 29
- Issue
- 12
- Pages
- 1525-1536
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2035167814
- Cited by
- 202
- References
- 29
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 13 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 14 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
- Keywords
- polyvinylidene fluoride, crystal microstructure, thermal processing, coloration, sterilization, beta phase, alpha phase, gamma phase, tensile properties, biocompatibility, vascular anastomosis, intimal hyperplasia, tissue reaction
- MeSH terms
- Animals, Aorta, Abdominal, Biocompatible Materials, Calorimetry, Differential Scanning, Crystallization, Dogs, Fluorocarbon Polymers, Foreign-Body Reaction, Materials Testing, Polyvinyls, Sutures, Tensile Strength, Vascular Surgical Procedures, Spectroscopy, Fourier Transform Infrared
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