The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration
Abstract
Development of fibrous matrices of bioceramic–biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. However, in order to produce electrospun fibers with homogeneous structure, it is essential for the ceramic powder to be fine and to remain stable in suspension. Herein, we developed a novel method whereby the bioceramic hydroxyapatite (HA) was kept in suspension in biopolymer poly(lactic acid) (PLA). The strategy was to introduce a surfactant hydroxysteric acid (HSA) between the hydrophilic HA powder and the hydrophobic chloroform‐dissolved PLA. The HA nanopowder was dispersed effectively in HSA and mixed homogeneously with PLA. Continuous and uniform fibers were generated successfully with diameters of ∼1–2 μm, and featured a well‐developed nanocomposite structure of HA nanopowder‐dispersed PLA. Initial cellular assays showed excellent cell attachment and proliferation and also enhanced expression of alkaline phosphatase at 7 days of culturing. The HA–PLA nanocomposite fibers may be potentially useful in tissue engineering applications, particularly as three‐dimensional substrates for bone growth. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
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Cites
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Cited by
Farah, S., Anderson, D. G., & Langer, R. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.012 · Cited by 3,443
Processing technologies for poly(lactic acid)
Lim, L.-T., Auras, R., & Rubino, M. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.05.004 · Cited by 2,766
Polymeric materials for bone and cartilage repair
Puppi, D., Chiellini, F., Piras, A. M., & Chiellini, E. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.01.006 · Cited by 913
One‐Dimensional Composite Nanomaterials: Synthesis by Electrospinning and Their Applications
Lu, X., Wang, C., & Wei, Y. (2009) · Small · doi:10.1002/smll.200900445 · Cited by 874
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484
Metadata
- Authors
- Kim, H., Lee, H., & Knowles, J. C.
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2006-07-06
- Volume
- 79A
- Issue
- 3
- Pages
- 643-649
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2114035952
- Cited by
- 366
- References
- 23
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, H., Lee, H., & Knowles, J. C. (2006). Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration. Journal of Biomedical Materials Research Part A. https://doi.org/10.1002/jbm.a.30866
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
