Dopamine‐assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium
Abstract
Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, a facile deposition method based on dopamine polymerization was developed for preparation of HAp-coated titanium substrates for orthopedic applications. Nanostructured HAp was mixed with an alkaline dopamine solution and then deposited onto titanium to form a dopamine/HAp ad-layer. The deposition of dopamine/HAp greatly enhanced the adhesion, proliferation, and mineralization of osteoblasts. Furthermore, RGD-containing peptides were immobilized to dopamine/HAp coated titanium and further enhanced cell adhesion and osteogenic differentiation. In conclusion, this facile dopamine-assisted surface modification method shows a great potential for orthopedic and dental applications.
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The effect of polydopamine on osteoblast proliferation and calcium deposition is further strengthened in combination with growth factors.
“It has been reported that PDA enhances the proliferation and calcium deposition of osteoblast cells and the effect can be further strengthened in the combination of growth factors [71, 72].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [72]
Polydopamine enhances proliferation and calcium deposition of osteoblast cells.
“It has been reported that PDA enhances the proliferation and calcium deposition of osteoblast cells and the effect can be further strengthened in the combination of growth factors [71, 72].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [72]
PDA-assisted surface modification to Ti and Ti alloys offers osteoconductivity to bioinert metallic bone biosubstitutes.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [72]
PDA-assisted surface modification to Ti and Ti alloys offers osteoinductivity to bioinert metallic bone biosubstitutes.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [72]
PDA-assisted surface modification to Ti and Ti alloys enhances cell viability, proliferation, differentiation, and material mineralization.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [72]
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
Liu, Z., Qu, S., Zheng, X., Xiong, X., Fu, R., Tang, K., Zhong, Z., & Weng, J. (2014) · Materials Science and Engineering: C · doi:10.1016/j.msec.2014.07.063 · Cited by 67 · see citing works
Polydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56 · see citing works
Xu, Y., Li, H., Wu, J., Yang, Q., Jiang, D., & Qiao, B. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s181137 · Cited by 42 · see citing works
- Authors
- Chien, C., Liu, T., Kuo, W., Wang, M., & Tsai, W.
- Affiliations
- National Taiwan University (TW)
- National Yang Ming University (TW)
- National Taiwan University of Science and Technology (TW)
- Corresponding author
- Tsai, Wei‐Bor
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2012-08-31
- Volume
- 101A
- Issue
- 3
- Pages
- 740-747
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2061310848
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 5
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- hydroxyapatite nanoparticles, RGD peptide, titanium implants, osteoconductivity, osseointegration, osteoblast adhesion, osteogenic differentiation, surface modification, orthopedic implants, dental implants
- MeSH terms
- Animals, Bone Regeneration, Cell Adhesion, Cell Line, Dopamine, Materials Testing, Oligopeptides, Osteoblasts, Osteogenesis, Titanium, Durapatite, Coated Materials, Biocompatible, Cell Proliferation, Rats, Nanoparticles
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