Cited by 111Magnesium Alloys: Properties and ApplicationsAntimicrobial agents and applicationsTitanium Alloys Microstructure and Properties

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Alkalization is responsible for antibacterial effects of corroding magnesium

Rahim, Muhammad Imran, Eifler, Rainer, Rais, Bushra, Mueller, Peter P.·2015·Journal of Biomedical Materials Research Part A

DOI 10.1002/jbm.a.35503

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Abstract

Magnesium alloys are presently investigated as potential medical implant materials for temporary applications. Magnesium has been reported to have antibacterial activities and could therefore be used to prevent antibiotic treatment-resistant bacterial implant infections. For characterizing the effects of magnesium on infectious bacteria, bioluminescent S. aureus or P. aeruginosa were employed. The proliferation of both types of bacteria was suppressed in the presence of metallic magnesium and also in aqueous magnesium corrosion extracts. Of the two soluble corrosion products, magnesium ions were well tolerated while antibacterial activities correlated with increased pH levels of the supernatants. The alkaline pH alone was sufficient for the antibacterial effects which were completely abolished when the pH of the corrosion supernatants was neutralized. These results demonstrate that pH increases are necessary and sufficient for the antibacterial activity of metallic magnesium. In an animal model magnesium implants showed an enhanced but variable resistance to bacterial colonization.

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In vivo corrosion of four magnesium alloys and the associated bone response
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., Meyer‐Lindenberg, A., Wirth, C. J., & Windhagen, H. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.049 · Cited by 2,403
In vitro and in vivo corrosion measurements of magnesium alloys
Witte, F., Fischer, J., Nellesen, J., Crostack, H. ‐., Kaese, V., Pisch, A., Beckmann, F., & Windhagen, H. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.07.037 · Cited by 1,389
The anodic dissolution of magnesium in chloride and sulphate solutions
Song, G., Atrens, A., John, D. S., Wu, X., & Nairn, J. (1997) · Corrosion Science · doi:10.1016/s0010-938x(97)00090-5 · Cited by 892
Corrosion of magnesium
Makar, G. L., & Kruger, J. (1993) · International Materials Reviews · doi:10.1179/imr.1993.38.3.138 · Cited by 786
General and Localized Corrosion of Magnesium Alloys: A Critical Review
GHALI, E. L., Dietzel, W., & Kainer, K. U. (2004) · Journal of Materials Engineering and Performance · doi:10.1361/10599490417533 · Cited by 478
Biodegradable magnesium scaffolds: Part 1: Appropriate inflammatory response
Witte, F., Ulrich, H., Rudert, M., & Willbold, E. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31170 · Cited by 411
In vitro antibacterial properties of magnesium metal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus☆
Robinson, D. A., Griffith, R. W., Shechtman, D., Evans, R. B., & Conzemius, M. G. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.10.007 · Cited by 351
Novel magnesium phosphate cements with high early strength and antibacterial properties
Mestres, G., & Ginebra, M. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.12.008 · Cited by 309
Titanium oral implants: surface characteristics, interface biology and clinical outcome
Palmquist, A., Omar, O., Esposito, M. A., Lausmaa, J., & Thomsen, P. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0118.focus · Cited by 259
In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation
Zhang, E., Xu, L., Yu, G., Pan, F. M., & Yang, K. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32132 · Cited by 257

Show all 43 references

Research works printed but not linked: 2

10.1128/AAC.03936-14 · DOI
Sambrook J, 2001, Molecular Cloning: A Laboratory Manual

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Self-citation
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Zhang, X.-Z., Chen, M., Hou, R., Wang, W., He, Z.-D., You, J., & Song, X. (2026) · Molecules · doi:10.3390/molecules31071204 · Cited by 18
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Wu, H. W., Yu, M., Zhang, S., You, M., Xiong, A., Feng, B., Niu, J., Yuan, G., Yue, B., & Jia, P. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02744a · Cited by 8
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“3c and d), with the latter ’ s partial suppression aligning with known anti-bacterial/antibiofilm effects derived from corroding Mg [29,30].”
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Bucher, C. H., Fischer, H., Ellinghaus, A., Schmidt-Bleek, O., Jahn, D., Soares, A. P., Tsitsilonis, S., Duda, G. N., Heiland, M., Schmidt‐Bleek, K., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.09.023 · Cited by 1
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Kirtiş, T., Eğerci, Ö. F., Sonnow, L., Doğruöz, F., & Köse, Ö. (2023) · Fuß & Sprunggelenk · doi:10.1016/j.fuspru.2023.08.002 · Cited by 1
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Filho, J. C. C. F., Martins, M. L., Marre, A. T. D. O., Almeida, J. S. D. S., Lobo, L. A., da Cruz, A. G., Andrade, M. M., Vieira, T. I., Romanos, M. T. V., Maia, L. C., et al. (2020) · doi:10.1002/9781119618973.ch7
Biodegradable Metals
Aghion, E. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-387-4
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Zhou, M., Wang, Y., & Chen, Y. (2023) · Materials Research Express · doi:10.1088/2053-1591/acbc0c

Authors: Rahim, M. I., Eifler, R., Rais, B., & Mueller, P. P.
Affiliations: Helmholtz Centre for Infection Research (DE)
Leibniz University Hannover (DE)
Corresponding author: Mueller, Peter P.
ORCID: Rahim, Muhammad Imran
Mueller, Peter P.
Venue: Journal of Biomedical Materials Research Part A
Publisher: Wiley
Published: 2015-05-24
Volume: 103
Issue: 11
Pages: 3526-3532
ISSN: 1549-3296 (ISSN-L)
1552-4965
DOI: 10.1002/jbm.a.35503
OpenAlex: W2131108244
Cited by: 111
References: 43
Citations by year: 2026: 11 · 2025: 13 · 2024: 12 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 9
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Biomedical Materials Research Part A (publishedVersion)
PubMed (publishedVersion)
Funders: German Research Foundation (DFG) (SFB 599, projects D1, R8, and DR1)
Joint stipend of the Higher Education Commission of Pakistan; German Academic Exchange Service (DAAD), Germany
Topics: Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
Keywords: magnesium corrosion, antibacterial activity, alkalization, pH, magnesium alloys, biomedical implants, implant-associated infection, Staphylococcus aureus, Pseudomonas aeruginosa, corrosion products, magnesium ions, bacterial colonization
MeSH terms: Alkalies, Animals, Anti-Bacterial Agents, Corrosion, Disease Models, Animal, Female, Hydrogen-Ion Concentration, Ions, Magnesium, Mice, Inbred BALB C, Microbial Sensitivity Tests, Pseudomonas aeruginosa, Solubility, Staphylococcus aureus, Prosthesis-Related Infections, Imaging, Three-Dimensional

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Alkalization is responsible for antibacterial effects of corroding magnesium

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