The role of antibacterial metallic elements in simultaneously improving the corrosion resistance and antibacterial activity of magnesium alloys
Open accessAbstract
Magnesium-based biodegradable alloys exhibit excellent mechanical properties and bioactivity, which are favorable in the orthopedic applications. In addition, the degradation of Mg alloys results in an alkaline microenvironment which can effectively withstand bacteria. However, the degradation rate of Mg is too fast to sustain the healing process. And enhancement of its corrosion resistance may compromise the antibacterial ability, thus, alloying with antibacterial elements or doping these elements into coatings on Mg and its alloys may be a prospective strategy to combine the corrosion resistance and antibacterial activity together. This review mainly discussed the role of common antibacterial metallic elements in improving the antibacterial properties and corrosion resistance of Mg-based alloys, including sliver (Ag), Zinc (Zn) and Copper (Cu). Besides, the potential antibacterial mechanism of Mg has been proposed systematically.
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Uncoated Mg reduced microbial adhesion significantly, likely due to release of corrosion products (Zn2+/H2/OH−).
“Uncoated Mg also reduced microbial adhesion significantly, likely owing to the release of corrosion products (Zn2+/H2/OH−) during rapid corrosion [[29], [30], [31]].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [29]
Section 2 reports lower MRSA colonization on pure Mg than on titanium, and §2.2 says alkalinity from Mg degradation inhibits bacterial adhesion (page numbers unavailable in our copy). The paper does not establish a statistically significant reduction in adhesion or link that reduction on uncoated Mg to Zn²⁺ or H₂ release; §3.2 discusses antibacterial Zn ions in Mg–Zn alloys instead. (LLM, conf=0.87)
Experimental — accuracy not yet measuredTNE@AHAC significantly reduced biofilm biomass versus Control and bare Mg.
“Crystal violet staining demonstrated significantly reduced biofilm biomass on TNE@AHAC versus Control and bare Mg (Fig. 3c and d), with the latter's partial suppression aligning with known antibacterial/antibiofilm effects derived from corroding Mg [29,30].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [29]
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Wu, Y., Cai, Z., Zhang, Y., Zheng, Y., Liao, L., & Jia, Z. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.018 · Cited by 7 · see citing works
“Uncoated Mg also reduced microbial adhesion significantly, likely owing to the release of corrosion products (Zn 2 + /H 2 /OH (cid:0) ) during rapid corrosion [29 – 31].”
Sahoo, S. N., Avula, I., Mandal, S., Pal, S., Balla, V. K., & Roy, M. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00488h · Cited by 3 · see citing works
- Authors
- Lin, Z., Sun, X., & Yang, H.
- Affiliations
- China Medical University (CN)
- Corresponding author
- Sun, Xiaoting
- Yang, Huazhe
- Venue
- Materials & Design
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 198
- Pages
- 109350
- ISSN
- 0264-1275 (ISSN-L)
- OpenAlex
- W3109732262
- Cited by
- 156
- References
- 105
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 24 · 2023: 31 · 2022: 36 · 2021: 16
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials & Design (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- magnesium alloys, antibacterial activity, corrosion resistance, biodegradable alloys, silver doping, zinc doping, copper doping, antibacterial coatings, orthopedic implants, degradation rate, antibacterial mechanism, alkaline microenvironment
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