Surface patterning: Tool to modulate stem cell differentiation in an adipose system
Abstract
There are several issues that need to be better understood before breast tissue‐engineering becomes viable clinically. One of the key issues is the interaction between cells and the microtopography of the implant surface. The aim of this study was to evaluate the efficacy of D1 cells, multipotent mouse bone marrow stromal precursors, in differentiating to fat and to characterize their metabolic activity (lactic acid released and glucose consumed) and lipid production when cultured on patterned poly‐L‐lactide (PLLA) films. It was determined that, with appropriate stimulation, the D1 cells displayed morphological characteristics of adipocytes and produced lipid. The results show that the patterned surfaces did affect the rate of lipid production. Polynomial models were proposed to predict the metabolic activity of the cells over a period of time. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chaubey et al. found that patterned PLLA surfaces had a faster rate of differentiation than non-patterned PLLA.
“The patterned PLLA surfaces were shown to have a faster rate of differentiation than non-patterned PLLA.”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [18]
At later time points, patterned PLLA surfaces produced the highest amount of lipids, followed by PS, then non-patterned PLLA.
“As for lipid production, it was found that, at later time points, patterned PLLA surfaces produced the highest amount of lipids, followed by PS, and then non-patterned PLLA.”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [18]
Micro-patterning and type of surface both affected the rate of differentiation of cells.
“The results indicated that the micro-patterning and type of surface both affected the rate of differentiation of cells (18).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [18]
Cells cultured on patterned and non-patterned PLLA surfaces showed a lower rate of differentiation compared with cells on tissue culture-treated polystyrene.
“However, cells cultured on patterned and non-patterned PLLA surfaces showed a lower rate of differentiation compared with cells on tissue culture-treated polystyrene (PS), a control for the experiment.”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [18]
Cites
Martin, J. Y., Schwartz, Z., Hummert, T. W., Schraub, D. M., Simpson, J., Lankford, J., Dean, D. D., Cochran, D. L., & Boyan, B. D. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820290314 · Cited by 1,113 · see citing works
Topographical control of cell behaviour: II. multiple grooved substrata
Clark, P., Connolly, P., Curtis, A. S. G., Dow, J. A. T., & Wilkinson, C. D. W. (1990) · Development · doi:10.1242/dev.108.4.635 · Cited by 682 · see citing works
Wan, Y., Wang, Y., Liu, Z., Qu, X., Han, B., Bei, J., & Wang, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.016 · Cited by 342 · see citing works
Frontiers in Tissue Engineering
(1998) · Elsevier eBooks · doi:10.1016/b978-0-08-042689-1.x5001-8 · Cited by 267 · see citing works
Osteoblast-Mediated Mineral Deposition in Culture is Dependent on Surface Microtopography
Boyan, B. D., Bonewald, L. F., Paschalis, E. P., et al. (2002) · Calcified Tissue International · doi:10.1007/s00223-001-1114-y · Cited by 258 · see citing works
The influence of micro-topography on cellular response and the implications for silicone implants
von Recum, A. F., & van Kooten, T. G. (1996) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856295x00698 · Cited by 251 · see citing works
Hormonal Chemoprevention of Cancer in Women
Henderson, B. E., Ross, R. K., & Pike, M. C. (1993) · Science · doi:10.1126/science.8381558 · Cited by 240 · see citing works
Lossdörfer, S., Schwartz, Z., Wang, L., Lohmann, C. H., Turner, J. D., Wieland, M., Cochran, D. L., & Boyan, B. D. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30025 · Cited by 227 · see citing works
Biological fixation of porous-coated implants
Haddad, R. J., Cook, S. D., & Thomas, K. A. (1987) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198769090-00026 · Cited by 142 · see citing works
Microtopography and Soft Tissue Response
Campbell, C., & von Recum, A. F. (1989) · Journal of Investigative Surgery · doi:10.3109/08941938909016503 · Cited by 134 · see citing works
Inoue, T., COX, J. E., Pilliar, R. M., et al. (1987) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820210114 · Cited by 116 · see citing works
Matsuzaka, K., Walboomers, F., de Ruijter, A., et al. (2000) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.2000.011004325.x · Cited by 95 · see citing works
Texturing of polymer surfaces at the cellular level
Schmidt, J. A., & von Recum, A. F. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90006-v · Cited by 89 · see citing works
Macrophage response to microtextured silicone
Schmidt, J. A., & von Recum, A. F. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90138-e · Cited by 84 · see citing works
Effect of surface roughness on platelet adhesion under static and under flow conditions.
Zingg, W., Neumann, A. W., Strong, A. B., et al. (1982) · PubMed · Cited by 54 · see citing works
Parker, J. A. T. C., Walboomers, X. F., den Hoff, J. W. V., Maltha, J. C., & Jansen, J. A. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10170 · Cited by 44 · see citing works
Tissue Engineered Adipose Tissue
Patrick, C., Chauvin, P., & Robb, G. L. (1998) · Elsevier eBooks · doi:10.1016/b978-008042689-1/50021-2 · Cited by 29 · see citing works
Adipocyte Response to Injectable Breast Tissue Engineering Scaffolds
Cavin, M., & Nichole, A. (2005) · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Modeling physiological events in 2D vs. 3D cell culture
Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849 · see citing works
Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems
Silva-Pedrosa, R., Salgado, A. J., & Ferreira, P. E. (2023) · Cells · doi:10.3390/cells12060930 · Cited by 84 · see citing works
Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells
Pistollato, F., Bal-Price, A., Coecke, S., Parvatam, S., Pamies, D., Czysz, K., Hao, J., Kee, K., Teo, A. K. K., Niu, S., et al. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.06.003 · Cited by 10 · see citing works
- Authors
- Chaubey, A., Ross, K. J., Leadbetter, R. M., & Burg, K. J. L.
- Affiliations
- Clemson University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Burg, Karen J. L.
- Venue
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Publisher
- Wiley
- Published
- 2007-04-23
- Volume
- 84B
- Issue
- 1
- Pages
- 70-78
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W2117090777
- Cited by
- 50
- References
- 18
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- surface patterning, stem cell differentiation, adipogenesis, mesenchymal stem cells, microtopography, lipid production, metabolic activity, lactic acid release, glucose utilization, polynomial model
- MeSH terms
- Adipose Tissue, Azo Compounds, Cell Differentiation, Cell Line, Coloring Agents, Glucose, Lipids, Microscopy, Phase-Contrast, Polyesters, Regression Analysis, Stem Cells, Surface Properties, Adipocytes, Lactic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
