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Cited by 47Osteoarthritis Treatment and MechanismsBone Tissue Engineering MaterialsTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Articular cartilage tissue engineering based on a mechano‐active scaffold made of poly(L‐lactide‐co‐ε‐caprolactone): In vivo performance in adult rabbits

Xie, Jun, Han, Zhiyi, Naito, Masatoshi, Maeyama, Akira, Kim, Soo Hyun, Kim, Young Ha, Matsuda, Takehisa·2010·Journal of Biomedical Materials Research Part B: Applied Biomaterials
DOI 10.1002/jbm.b.31627
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Abstract

Our previous studies showed that a mechano‐active scaffold made of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) exhibited a high potential to realize the formation of a functional, engineered cartilage in vitro. This animal study therefore was designed to investigate the feasibility of repairing on osteochondral defect with the use of bone marrow‐derived mesenchymal stem cells (BMSCs) incorporated with a PLCL scaffold. Rabbit BMSCs, isolated and subsequently cultured in monolayer, were seeded into a porous PLCL scaffold sponge following an implantation onto a full‐thickness osteochondral defect (diameter of 4.5 mm, depth of 5 mm) that was artificially created on the medial femoral condyles at a high load‐bearing site on a rabbit's knee joint. Time‐dependent healing of the defect was evaluated by macroscopic, histological examinations at both 3‐ and 6‐month‐implantations, respectively. A PLCL sponge incorporated with BMSCs exhibited sufficient structural support, resulting in new osteochondral tissue regeneration: a physiologically well‐integrated subchondral bone formation, a hyaline cartilage‐like morphology containing chondrocytes surrounded by abundant cartilaginous matrices. In addition, quantitative biochemical assays also demonstrated high potential for the synthesis of sulfated glycosaminoglycan and collagen, both of which are biomolecules essential to extracelluar matrix in normal cartilage tissue. In contrast, defects filled with cell‐free PLCL scaffold or left empty showed a very limited potential for regeneration. Our findings suggest that a composite of PLCL‐based sponge scaffold and BMSCs promote the repair of osteochondral defects at high load‐bearing sites in adult rabbits. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

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Crossref · 10.1002/jbm.b.31627

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  • Combination of PLCL with collagen and hyaluronic acid is beneficial to formation of cartilage.

    “The combination of PLCL with collagen and hyaluronic acid is beneficial to the formation of cartilage [228].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [228]

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Metadata

Authors
Xie, J., Han, Z., Naito, M., Maeyama, A., Kim, S. H., Kim, Y. H., & Matsuda, T.
Affiliations
  • Fukuoka University (JP)
  • Kyushu University (JP)
  • Korea Institute of Science and Technology (KR)
  • Kanazawa Institute of Technology (JP)
Corresponding author
Xie, Jun
ORCID
Venue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Published
2010-03-24
Volume
94B
Issue
1
Pages
80-88
ISSN
  • 1552-4973 (ISSN-L)
  • 1552-4981
DOI
10.1002/jbm.b.31627
OpenAlex
W2162190061
Cited by
47
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 7
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
articular cartilage tissue engineering, poly(L-lactide-co-ε-caprolactone), bone marrow-derived mesenchymal stem cells, osteochondral repair, full-thickness cartilage defects, subchondral bone formation, hyaline cartilage regeneration, sulfated glycosaminoglycans, collagen synthesis, extracellular matrix, load-bearing joints, rabbit knee
MeSH terms
Animals, Biocompatible Materials, Bone Marrow Cells, Cartilage, Articular, Humans, Materials Testing, Polyesters, Rabbits, Tissue Engineering, Tissue Scaffolds, Mesenchymal Stem Cells

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