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Cited by 9

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Comprehensive reparative effects of bacteriostatic poly(L‐lactide‐co‐glycolide)/poly(L‐lactide‐co‐ε‐caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis

Liu, Yiming, Zhao, Yun, Zhu, Wanchun, Han, Mei, Mi, Fanglin, Wang, Bing·2023·Journal of Biomedical Materials Research Part B: Applied Biomaterials
DOI 10.1002/jbm.b.35168
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Abstract

Periodontitis is a chronic inflammatory disease that leads to the loss of alveolar bone, among several studies focusing on reconstructing periodontal bone caused by periodontitis, guided bone regeneration (GBR) is a promising approach. In this study a serial clinically applied antibiotics loaded poly(L‐lactide‐co‐glycolide)/poly(L‐lactide‐co‐ε‐caprolactone) (PLGA/PLCA) fibrous mesh to prevent and reconstruct defective bone in periodontitis were prepared by electrospinning. Incorporation of antibiotics promoted the hydrophilicity but decreased the crystallinity of PLGA/PLCA membranes. Antibiotics could be sustained released from membranes. Metronidazole, minocycline, and doxycycline incorporated membranes could suppress Porphyromonas gingivalis ( P. gingivalis ) within 21 days in vitro. Metronidazole and minocycline incorporated membranes decreased 41% and 55.5% colony counts in rat gingival crevicular fluid in vivo. Minocycline‐loaded membrane could support the proliferation of MC3T3‐E1 cells and maintained 79% viability of human ligament fibroblasts cultured on it. And MC3T3‐E1 cells could undergo osteoblastic differentiation when cultured with pure PLGA/PLCA membrane and minocycline incorporated membrane. Then in vivo repairable effects of those antibiotics loaded membranes were evaluated in alveolar bone defected P. gingivalis infected model. The application of minocycline loaded membranes, effectively prevented the bone resorption of periodontitis caused by P. gingivalis . After been treated with minocycline incorporated membrane, volume of defected bone of maintained at about 50% level of control rats. 8 weeks post‐operation, newly regenerated bone was observed in the operative alveolar bone of the pure PLGA/PLCA membrane, metronidazole and minocycline incorporated PLGA/PLCA membrane treated groups. Minocycline/PLGA/PLCA electrospinning membrane is a promising GBR material that can be applied to guide regeneration of periodontitis‐induced alveolar bone damage.

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Metadata

Authors
Liu, Y., Zhao, Y., Zhu, W., Han, M., Mi, F., & Wang, B.
Venue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Published
2022-10-05
Volume
111
Issue
3
Pages
513-525
ISSN
  • 1552-4973
  • 1552-4981
DOI
10.1002/jbm.b.35168
Cited by
9
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Comprehensive reparative effects of bacteriostatic poly(L‐lactide‐co‐glycolide)/poly(L‐lactide‐co‐ε‐caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis. https://app.cochat.ai/papers/10.1002/jbm.b.35168
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Liu, Y., Zhao, Y., Zhu, W., Han, M., Mi, F., & Wang, B. (2023). Comprehensive reparative effects of bacteriostatic poly(L‐lactide‐co‐glycolide)/poly(L‐lactide‐co‐ε‐caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis. Journal of Biomedical Materials Research Part B: Applied Biomaterials. https://doi.org/10.1002/jbm.b.35168

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.