Polydopamine Nanoparticles as Efficient Scavengers for Reactive Oxygen Species in Periodontal Disease
Abstract
Antioxidative therapy has been considered an efficient strategy for the treatment of a series of excessive reactive oxygen species (ROS)-triggered diseases, including oxidative-stress-induced periodontal disease. However, current natural enzymes and nanozymes often show their high specificity toward given ROS and have insufficient antioxidative effects against multiple ROS generated in the diseases process. Meanwhile, multienzyme-based antioxidant defense systems are usually confined by the complicated synthesis as well as potential unwanted residue and toxicity. Various supports are highly needed to immobilize natural enzymes and antioxidants during the biorelated usages due to their low operational stability and difficulty of reuse. To overcome these limitations, we develop a high-performance platform by using biodegradable polydopamine nanoparticles (PDA NPs) as smart ROS scavengers in oxidative stress-induced periodontal disease. Although PDA-based materials are well-known to eliminate ROS both in vitro and in vivo, their antioxidative performance in periodontal disease and relative mechanisms have yet to be well-explored. In this study, PDA NPs can act as ROS scavengers in dental specialties with ideal outcomes. Spectroscopic and in vitro experiments provide strong evidence for the roles of PDA NPs in scavenging multiple ROS and suppressing ROS-induced inflammation reactions. In addition to the above investigations, the results from a murine periodontitis model clearly d…
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Through its intrinsic redox-regulating capability, PDA modulates the local oxidative microenvironment, exerting anti-inflammatory and tissue-protective effects.
“Through its intrinsic redox-regulating capability, PDA is able to modulate the local oxidative microenvironment, thereby exerting anti-inflammatory and tissue-protective effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
The catechol moieties within PDA function as reducing agents and free radical scavengers, neutralizing reactive oxygen species including superoxide anions, hydroxyl radicals, and hydrogen peroxide.
“The catechol moieties within the PDA structure function as effective reducing agents and free radical scavengers, enabling efficient neutralization of various reactive oxygen species (ROS), including superoxide anions, hydroxyl radicals, and hydrogen peroxide.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
PDA-based nanoparticles or hydrogels are capable of adsorbing and neutralizing excess ROS, thereby directly exerting antioxidant and anti-inflammatory effects.
“PDA-based nanoparticles or hydrogels are capable of adsorbing and neutralizing these excess ROS, thereby directly exerting antioxidant and anti-inflammatory effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
PDA functions as an efficient scavenger of reactive oxygen species (ROS).
“As discussed above, PDA functions as an efficient scavenger of reactive oxygen species (ROS).”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
Through this redox-regulating mechanism, PDA-based systems can effectively protect periodontal tissues from oxidative injury and contribute to inflammation resolution.
“Through this redox-regulating mechanism, PDA-based systems can effectively protect periodontal tissues from oxidative injury and contribute to inflammation resolution.12,51”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show that PDA-based systems can achieve biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.
“In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [12]
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“12 In numerous oral pathological conditions, such as periodontitis, peri-implantitis, and wound healing processes, excessive ROS generation leads to oxidative stress, which in turn aggravates tissue injury and inflammatory responses.”
- Authors
- Bao, X., Zhao, J., Sun, J., Hu, M., & Yang, X.
- Affiliations
- Jilin University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Yang, Xiurong
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-07-20
- Volume
- 12
- Issue
- 9
- Pages
- 8882-8892
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2883552344
- Cited by
- 722
- References
- 3
- Citations by year
- 2026: 92 · 2025: 119 · 2024: 135 · 2023: 110 · 2022: 95 · 2021: 85 · 2020: 52 · 2019: 32 · 2018: 1
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- People's Government of Jilin Province (20160520156JH)
- Jilin University (2015321)
- National Natural Science Foundation of China (21435005, 21627808)
- Chinese Academy of Sciences (QYZDY-SSW-SLH019)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- polydopamine nanoparticles, reactive oxygen species scavenging, periodontal disease, periodontitis, oxidative stress, antioxidant therapy, periodontal inflammation, biodegradable nanoparticles
- MeSH terms
- Animals, Antioxidants, Cell Survival, Cells, Cultured, Humans, Indoles, Lipopolysaccharides, Mice, Inbred Strains, Periodontal Diseases, Polymers, Free Radical Scavengers, Reactive Oxygen Species, Inflammation Mediators, Mice, Nanoparticles, Optical Imaging
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