The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Microbial colonization of the periodontal pocket and its significance for periodontal therapy
Open accessAbstract
The aim of this paper was to evaluate strategies for periodontal therapy from the perspective of periodontal disease being a consequence of microbial colonization of the periodontal pocket environment. In classic bacterial infections the diversity of the microbiota decreases as the disease develops. In most cases of periodontitis, however, the diversity of the flora increases. Most incriminating bacteria are thought to harm tissues significantly only if present in high numbers over prolonged periods of time. Clinical trials have repeatedly demonstrated that scaling and root planing, a procedure that aims to remove subgingival bacterial deposits by scraping on the tooth surface within the periodontal pocket, is effective. At present, for the therapy of any form of periodontal disease, there exists no protocol with proven superiority, in terms of efficiency or effectiveness, over scaling and root planing plus systemic amoxicillin and metronidazole. Some exponents advocate rationing these drugs for patients with a specific microbial profile. However, the evidence for any benefit of bacteriology‐assisted clinical protocols is unsatisfactory. Treated sites are subject to recolonization with a microbiota similar to that present before therapy. The degree and speed of recolonization depends on the treatment protocol, the distribution patterns of periodontal microorganisms elsewhere in the oral cavity and the quality of the patient's oral hygiene. To limit the use of antibiotics and to avoid accumulation of harmful effects by repeated therapy, further efforts must be made to optimize procedures addressing the microbial colonization and recolonization of the periodontal pocket.
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Citations
Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050 · cited 1×
“Amoxicillin and metronidazole may very well have effects beyond suppressing the selected bacterial species and ‘complexes’ (99) that were monitored in previous clinical trials by bacterial culture, DNA–DNA hybridization or PCR.”
BackgroundExperimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · cited 2×
“), the patients were given detailed instructions in oral hygiene methods using brush and wood massage sticks’ (51).”
BackgroundMethodBacterial Diversity in Human Subgingival Plaque
Paster, B. J., Boches, S. K., Galvin, J. L., Ericson, R. E., Lau, C. N., Levanos, V. A., Sahasrabudhe, A., & Dewhirst, F. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.12.3770-3783.2001 · Cited by 2,011
Socransky, S. S., & Haffajee, A. D. (2005) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00107.x · Cited by 1,691
Microbial etiological agents of destructive periodontal diseases
Haffajee, A. D., & Socransky, S. S. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00020.x · Cited by 1,623
Assessment of Risk for Periodontal Disease. I. Risk Indicators for Attachment Loss
Grossi, S. G., Zambon, J. J., Ho, A. W., Koch, G., Dunford, R. G., Machtei, E. E., Norderyd, O. M., & Genco, R. J. (1994) · Journal of Periodontology · doi:10.1902/jop.1994.65.3.260 · Cited by 1,129
Experimental gingivitis in man: II. A Longitudinal Clinical and Bacteriological Investigation
Theilade, E., Wright, W. H., Jensen, S. B., & Löe, H. (1966) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1966.tb01842.x · Cited by 1,038
Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
Eyre, D. W., Cule, M. L., Wilson, D. J., Griffiths, D., Vaughan, A., O'Connor, L., Ip, C. L. C., Golubchik, T., Batty, E. M., Finney, J. M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1216064 · Cited by 648
Bacterial diversity within the human subgingival crevice
Kroes, I., Lepp, P. W., & Relman, D. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14547 · Cited by 606
Wilson Jr., T. G. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.090115 · Cited by 604
Cited by
Takesh, T., Goshtasbi, A., Lin, K., Yang, S. M., Wink, C., Geisinger, M. L., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0254 · Cited by 4
Geisinger, M. L., Geurs, N. C., Novy, B., Otomo‐Corgel, J., Cobb, C. M., Jacobsen, P. L., Takesh, T., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0675 · Cited by 3
Vaziri, F., Eidi, M., Maybodi, F. R., Dehkordi, N. R., & Khoddami, N. (2025) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1408_24
“[37] In consideration of this, the implementation of adjunctive therapy is important.”
Metadata
- Authors
- Mombelli, A.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2017-11-30
- Volume
- 76
- Issue
- 1
- Pages
- 85-96
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W2773936455
- Cited by
- 361
- References
- 99
- FWCI
- 26.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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