The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The osteoblast: An insulin target cell controlling glucose homeostasis
Open accessAbstract
The past five years have witnessed the emergence and discovery of unexpected functions played by the skeleton in whole-organism physiology. Among these newly described tasks is the role of bone in the control of energy metabolism, which is achieved through the secretion of osteocalcin, an osteoblasts-derived hormone regulating insulin secretion, insulin sensitivity, and energy expenditure. These initial findings raised several fundamental questions on the nature of insulin action in bone. Discoveries made independently by our two groups have provided answers recently to some of these questions. Through the analysis of mice lacking insulin receptor (InsR) only in osteoblasts, we found that insulin signaling in these cells favors whole-body glucose homeostasis. Importantly, this function of insulin signaling in osteoblasts was achieved through the negative regulation of osteocalcin carboxylation and bioavailability. Our studies also established that insulin signaling in osteoblasts was a positive regulator not only of postnatal bone acquisition but also of bone resorption. Interestingly, it appears that insulin signaling in osteoblasts induced osteocalcin activation by stimulating osteoclast activity. Indeed, the low pH generated during bone resorption is a sufficient means to decarboxylate osteocalcin. Our findings establish that the osteoblast is an important target used by insulin to control whole-body glucose homeostasis and identify bone resorption as the mechanism regulating osteocalcin activation. © 2011 American Society for Bone and Mineral Research.
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Shetty, S., Kapoor, N., Bondu, J. D., Thomas, N., & Paul, T. V. (2016) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.192914 · Cited by 330
“[15]”
The role of osteoblasts in energy homeostasis
Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0246-y · Cited by 292
Self-citationRegulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway
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Insulin Signaling in Arthritis
Tripolino, C., Ciaffi, J., Pucino, V., Ruscitti, P., van Leeuwen, N., Borghi, C., Giacomelli, R., Meliconi, R., & Ursini, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672519 · Cited by 46
Metadata
- Authors
- Clemens, T. L., & Karsenty, G.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-16
- Volume
- 26
- Issue
- 4
- Pages
- 677-680
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W1965682512
- Cited by
- 278
- References
- 19
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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