Cited by 292Bone Metabolism and DiseasesBone health and osteoporosis researchAdipokines, Inflammation, and Metabolic Diseases

The role of osteoblasts in energy homeostasis

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Dirckx, Naomi, Moorer, Megan C., Clemens, Thomas L., Riddle, Ryan C.·2019·Nature Reviews Endocrinology

Abstract

Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation.

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Authors
Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C.
Affiliations
Johns Hopkins University (US)
Corresponding author
Riddle, Ryan C.
Venue
Nature Reviews Endocrinology
Published
2019-08-28
Volume
15
Issue
11
Pages
651-665
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2970822705
Cited by
292
References
192
Citations by year
2026: 28 · 2025: 51 · 2024: 53 · 2023: 46 · 2022: 50 · 2021: 35 · 2020: 25 · 2019: 4
FWCI
2.52
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01 BX003724, IK6 BX004984, I01 BX001234)
  • Office of Research and Development
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099134)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
osteoblasts, energy homeostasis, bone remodeling, osteocalcin, lipocalin, sclerostin, bone formation, osteogenic differentiation, insulin, feeding behaviour, adipose tissue metabolism, glucose, fatty acids, amino acids
MeSH terms
Animals, Energy Metabolism, Homeostasis, Humans, Osteoblasts, Osteogenesis, Osteocalcin, Bone Remodeling, Adaptor Proteins, Signal Transducing, Lipocalins

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