The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men
Abstract
The osteoblast-derived protein osteocalcin has recently been shown to affect adiposity and glucose homeostasis in mice, suggesting that the skeleton influences energy metabolism through an endocrine mechanism. The aim of this study was to investigate the relationship between plasma osteocalcin and parameters reflecting fat mass and glucose homeostasis in humans. Fasting levels of plasma osteocalcin, plasma glucose, serum insulin, and lipids were analyzed in elderly men (75.3 ± 3.2 yr of age) in the Gothenburg part (all subjects, n = 1010; nondiabetic, n = 857; diabetic, n = 153) of the MrOS Sweden study. Fat mass and lean mass were analyzed using DXA. Diabetic subjects had lower plasma osteocalcin (−21.7%, p < 0.001) than nondiabetic subjects. For both all subjects and nondiabetic subjects, plasma osteocalcin was clearly inversely related to body mass index (BMI), fat mass, and plasma glucose (p < 0.001), whereas it was not associated with height or lean mass. Plasma osteocalcin explained a substantial part (6.3%) of the variance in plasma glucose, whereas it associated moderately with serum insulin. Multiple linear regression models adjusting for serum insulin and fat mass showed that plasma osteocalcin was an independent negative predictor of plasma glucose (p < 0.001). We herein, for the first time in humans, show that plasma osteocalcin is inversely related to fat mass and plasma glucose. Although one should be cautious with mechanistic interpretations of cross-sectional association studies, our human data support recently published experimental studies, showing endocrine functions of osteoblast-derived osteocalcin on glucose and fat homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735
Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone
Hauschka, P. V., Lian, J. B., Cole, D. E., & Gundberg, C. M. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.990 · Cited by 1,272
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,066
Relationship of Obesity with Osteoporosis
Zhao, L.-J., Liu, Y.-J., Liu, P.-Y., Hamilton, J., Recker, R. R., & Deng, H.-W. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0572 · Cited by 624
Ravn, P., Cizza, G., Bjarnason, N. H., Thompson, D., Daley, M., Wasnich, R. D., Mcclung, M., Hosking, D., Yates, A. J., & Christiansen, C. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1622 · Cited by 453
Relationship between body composition and bone mass in women
Khosla, S., Atkinson, E. J., Riggs, B. L., & Melton, L. J. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110618 · Cited by 341
Mellström, D., Johnell, O., Ljunggren, Ö., Eriksson, A.-L., Lorentzon, M., Mallmin, H., Holmberg, A., Redlund-Johnell, I., Orwoll, E., & Ohlsson, C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060110 · Cited by 337
Self-citationEffect of feeding on bone turnover markers and its impact on biological variability of measurements
Clowes, J. A., Hannon, R. A., Yap, T. S., Hoyle, N. R., Blumsohn, A., & Eastell, R. (2002) · Bone · doi:10.1016/s8756-3282(02)00728-7 · Cited by 296
Cited by
Ferron, M., McKee, M. D., Levine, R. L., Ducy, P., & Karsenty, G. (2012) · Bone · doi:10.1016/j.bone.2011.04.017 · Cited by 414
Fukumoto, S., & Martin, T. J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.02.001 · Cited by 311
The osteoblast: An insulin target cell controlling glucose homeostasis
Clemens, T. L., & Karsenty, G. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.321 · Cited by 278
Hwang, Y., Jeong, I., Ahn, K. J., & Chung, H. Y. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1045 · Cited by 214
Regulation of energy metabolism by the skeleton: osteocalcin and beyond
Ferron, M., & Lacombe, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.022 · Cited by 211
Metadata
- Authors
- Kindblom, J. M., Ohlsson, C., Ljunggren, Ö., Karlsson, M. K., Tivesten, Å., Smith, U., & Mellström, D.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-01
- Volume
- 24
- Issue
- 5
- Pages
- 785-791
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2019258161
- Cited by
- 354
- References
- 16
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men. https://app.cochat.ai/papers/10.1359/jbmr.081234
- The paper
- Kindblom, J. M., Ohlsson, C., Ljunggren, Ö., Karlsson, M. K., Tivesten, Å., Smith, U., & Mellström, D. (2009). Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men. Journal of Bone and Mineral Research. https://doi.org/10.1359/jbmr.081234
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
