The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse
Abstract
Mouse calvaria-derived osteoblastlike cells have been shown to produce macrophage colony-stimulating factor (M-CSF). This factor may be involved in osteoclastogenesis and thus in bone resorption. In the present study we investigated whether the production of M-CSF was altered in the osteopetrotic mouse mutant strain op/op, characterized by a decrease in osteoclast number and an impairment of bone resorption. Whole calvariae and cells, as well as skin and lung fibroblasts, of the op/op mouse were found to produce no measurable M-CSF, in contrast to tissue and cells derived from normal littermates. M-CSF was identified by colony assay in semisolid media and by inhibition of the biologic activity with antiserum against M-CSF. Furthermore, the number of resident macrophages, identified by F4/80 antigen (F4/80 Ag) immunohistochemistry, was drastically decreased in bone and bone marrow of the op/op mouse, but in skin these cells were normal in number and morphology. These findings suggest that both M-CSF and resident macrophages play a role in the mechanism of bone resorption. The op/op mouse appears to be a valuable model to further investigate such a hypothesis.
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Cites
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Cited by
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Microglia development and function
Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154
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Pathophysiology of Inflammatory Bowel Disease: Innate Immune System
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Metadata
- Authors
- Dr. Felix, R., Cecchini, M. G., Hofstetter, W., Elford, P. R., Stutzer, A., & Fleisch, H.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-07-01
- Volume
- 5
- Issue
- 7
- Pages
- 781-789
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2008737860
- Cited by
- 269
- References
- 35
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse. https://app.cochat.ai/papers/10.1002/jbmr.5650050716
- The paper
- Dr. Felix, R., Cecchini, M. G., Hofstetter, W., Elford, P. R., Stutzer, A., & Fleisch, H. (1990). Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650050716
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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