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The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors
Open accessAbstract
Rapid progress has occurred recently in characterizing the molecular nature of the specific glycoprotein colony-stimulating factors (CSFs) controlling the proliferation; and some functional activities of granulocytes and monocyte-macrophages. All four known murine CSFs have been purified, and cDNAs for two have been cloned and expressed by mammalian and bacterial cells. Similarly, three human CSFs have been purified, and cDNAs for two cloned and expressed. This work has opened up the exciting prospects of testing the effects of these recombinant CSFs on hematopoiesis in vivo. Each CSF has a broader range of hematopoietic target cells than previously suspected, and it is now clear that the CSFs are not simply proliferative stimuli but can also regulate the functional activity of mature cells. There are increasing reasons to believe that these CSFs will be useful therapeutic agents in stimulating hematopoietic regeneration in leukopenic states and the functional activity of granulocytes and monocytes in infections.
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Citations
Cited by
The Human Hematopoietic Colony-Stimulating Factors
Clark, S. C., & Kamen, R. (1987) · Science · doi:10.1126/science.3296190 · Cited by 1,639
Pacifici, R., Brown, C., Puscheck, E., Friedrich, E., Slatopolsky, E., Maggio, D., McCracken, R., & Avioli, L. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5134 · Cited by 555
Ogawa, T., Kitagawa, M., & Hirokawa, K. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00137-8 · Cited by 224
Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident
Butturini, A., Gale, R., Lopes, D., Cunha, C., Ho, W., Sanpai, J., De Souza, P., Cordiero, J., Neto, C., De Souza, C., et al. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90121-3 · Cited by 113
Hirano, T., & Kishimoto, T. (1990) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-49295-2_14 · Cited by 57
Metadata
- Authors
- Metcalf, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1986-02-01
- Volume
- 67
- Issue
- 2
- Pages
- 257-267
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1675276494
- Cited by
- 897
- References
- 0
- FWCI
- 62.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Metcalf, D. (1986). The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood. https://doi.org/10.1182/blood.v67.2.257.257
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