Effects of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate on mouse osteoclasts.

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

Baron, R., Neff, L., Louvard, D., & Courtoy, P. J. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.6.2210 · Cited by 740 · see citing works

Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix.

Boonekamp, P. M., van der Wee-Pals, L. J. A., LENNEP, M. V., Cw, T., & Bijvoet, O. L. (1986) · PubMed · Cited by 345 · see citing works

SOME VIRUS ISOLATIONS FROM COMMON COLDS

Tyrrell, D. A. J., & PARSONS, R. (1960) · The Lancet · doi:10.1016/s0140-6736(60)90168-9 · Cited by 337 · see citing works

Structure-activity relationships of various bisphosphonates

Shinoda, H., Adamek, G., Felix, R., Fleisch, H. A., Schenk, R., & Hagan, P. (1983) · Calcified Tissue International · doi:10.1007/bf02405012 · Cited by 306 · see citing works

TREATMENT OF PAGET'S DISEASE WITH (3-AMINO-1-HYDROXYPROPYLIDENE)-1, 1-BISPHOSPHONATE (A.P.D.)

Frijlink, W. B., Bijvoet, O. L. M., Velde, J. T., & Heynen, G. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91318-7 · Cited by 257 · see citing works

Dichloromethylenebisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone

Flanagan, A. M., & Chambers, T. J. (1989) · Bone and Mineral · doi:10.1016/0169-6009(89)90021-4 · Cited by 197 · see citing works

Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages

Cecchini, M. G., Felix, R., Fleisch, H. A., & Cooper, P. H. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020209 · Cited by 144 · see citing works

COMPARISON OF INTRAVENOUS (3-AMINO-1-HYDROXYPROPYLIDENE)-1, 1-BISPHOSPHONATE AND VOLUME REPLETION IN TUMOUR-INDUCED HYPERCALCAEMIA

Sleeboom, H., van Oosterom, A. T., Bijvoet, O. L. M., GLEED, J. H., & O'Riordan, J. H. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90231-3 · Cited by 138 · see citing works

Differential Action of the Bisphosphonates (3-Amino-1-Hydroxypropylidene)-1,1-Bisphosphonate (APD) and Disodium Dichloromethylidene Bisphosphonate (Cl2MDP) on Rat Macrophage-mediated Bone Resorption In Vitro

Reitsma, P. H., Teitelbaum, S. L., Bijvoet, O. L. M., & Kahn, A. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110704 · Cited by 120 · see citing works

The effect of two diphosphonates on the resorption of mouse calvariain vitro

Reynolds, J. J., Minkin, C., Morgan, D. B., Spycher, D., & Fleisch, H. A. (1972) · Calcified Tissue International · doi:10.1007/bf02012561 · Cited by 111 · see citing works

Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group.

Boonekamp, P. M., Löwik, C. W. G. M., van der Wee-Pals, L. J. A., Ml, V. W.-V. L., & Bijvoet, O. L. (1987) · PubMed · Cited by 100 · see citing works

Thyrocalcitonin and bone resorption

Raisz, L. G., Au, W. Y. W., Friedman, J., & Niemann, I. (1967) · The American Journal of Medicine · doi:10.1016/0002-9343(67)90110-6 · Cited by 85 · see citing works

The alteration of osteoclast morphology by diphosphonates in bone organ culture

Rowe, D. J., & Hausmann, E. (1976) · Calcified Tissue International · doi:10.1007/bf02546397 · Cited by 76 · see citing works

Ethane-1-hydroxy-1,1-diphosphonate (EHDP) effects on incorporation and accumulation of osteoclast nuclei

Miller, S. C., Jee, W. S. S., Kimmel, D. B., & Woodbury, L. A. (1977) · Calcified Tissue International · doi:10.1007/bf02010363 · Cited by 52 · see citing works

The role of bone scanning in paget's disease

Fogelman, I., Carr, D. H., & Boyle, I. T. (1981) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(81)90040-0 · Cited by 38 · see citing works

Parathyroid hormone-stimulated development of osteoclasts in cultures of cells from neonatal murine calvaria

Jilka, R. L. (1986) · Bone · doi:10.1016/8756-3282(86)90149-3 · Cited by 37 · see citing works

The effect of long-term low-dose diphosphonate treatment on rat bone.

EVANS, R. A., HOWLETT, C. R., DUNSTAN, C. R., & HILLS, E. (1982) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198205000-00044 · Cited by 32 · see citing works

Different schedules of administration of (3 amino-1-hydroxypropylidene)-1, 1 bisphosphonate induce different changes in pig bone remodeling

de Vernejoul, M. C., Pointillart, A., Bergot, C., Bielakoff, J., Morieux, C., Laval-Jeantet, A. M., & Miravet, L. (1987) · Calcified Tissue International · doi:10.1007/bf02555701 · Cited by 31 · see citing works

The effects of two diphosphonates on bone metabolism in the rat.

Evans, R. A., Baylink, D. J., & Wergedal, J. (1979) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(79)90017-1 · Cited by 30 · see citing works

Inhibition of bone matrix apposition by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (AHPrBP) in the mouse

Marie, P. J., Hott, M., & Garba, M.-T. (1985) · Bone · doi:10.1016/8756-3282(85)90053-5 · Cited by 27 · see citing works

A study of osteoclasts on calvaria of normal and osteopetrotic (mi/mi) mice by vital staining with acridine orange.

Green, P. M., Marshall, M. J. E., & Nisbet, N. W. (1986) · PubMed · Cited by 18 · see citing works

Inhibition of bone resorption by difluoromethylene diphosphonate in organ culture

Rowe, D. J., & Hays, S. J. (1983) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(83)90045-0 · Cited by 18 · see citing works

The effects of calcitonin and colchicine on the cellular response to diphosphonate.

Rowe, D. J., & Hausmann, E. (1980) · PubMed · Cited by 12 · see citing works

Biochemical assessment of acute and chronic treatment of Paget's bone disease with calcitonin and calcium with and without biphosphonate

Rico, H., Hernández, E. R., Younes, M., Hernández, D., & Espinos, D. (1988) · Bone · doi:10.1016/8756-3282(88)90028-2 · Cited by 9 · see citing works

Histologic study of the inhibition of bone resorption in organ cultures by myoinositol‐2‐monophosphate

Gomes, B. C., Kaufman, H. W., Archard, H. O., Cangemi, C., & Guerra, A. (1986) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1986.tb00564.x · Cited by 5 · see citing works

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, D., Mundy, G. R., & Boyce, B. F. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101008 · Cited by 1,039 · see citing works

Pathophysiologic interactions in skeletal metastasis

Orr, F. W., Lee, J., Duivenvoorden, W., & Singh, G. (2000) · Cancer · doi:10.1002/1097-0142(20000615)88:12+ · Cited by 79 · see citing works

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works

The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy.

Morony, S., Warmington, K., Adamu, S., Asuncion, F., Geng, Z., Grisanti, M., Tan, H. L., Capparelli, C., Starnes, C., Weimann, B., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1583 · Cited by 97 · see citing works

Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment

Ito, M., Amizuka, N., Nakajima, T., & Ozawa, H. (1999) · Bone · doi:10.1016/s8756-3282(99)00197-0 · Cited by 90 · see citing works

Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice

Deckers, M. M. L., van Beek, E. R., van der Pluijm, G., Wetterwald, A., van der Wee-Pals, L. J. A., Cecchini, M. G., Papapoulos, S. E., & Löwik, C. W. G. M. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.6.998 · Cited by 86 · see citing works

Inhibitory effects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor

Hiraga, T., Tanaka, S., Yamamoto, M., Nakajima, T., & Ozawa, H. (1996) · Bone · doi:10.1016/8756-3282(95)00428-9 · Cited by 66 · see citing works

Production of monoclonal antibodies to study corrosion products of CO-CR biomaterials

Yang, J. M., & Merritt, K. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199605)31:1 · Cited by 46 · see citing works

Osteoclast recruitment in mice is stimulated by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate.

Marshall, M. J., Holt, I., & John Davie, M. W. (1993) · Calcified Tissue International · doi:10.1007/bf00675622 · Cited by 37 · see citing works

Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/− Mice

Nijenhuis, T., van der Eerden, B. C. J., Hoenderop, J. G. J., Weinans, H., van Leeuwen, J. P. T. M., & Bindels, R. J. M. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080613 · Cited by 29 · see citing works

The aminobisphosphonate alendronate inhibits bone loss induced by thyroid hormone in the rat comparison between effects on tibiae and vertebrae

Balena, R., Markatos, A., Gentile, M., Masarachia, P. J., Seedor, J. G., Rodan, G. A., & Yamamoto, M. (1993) · Bone · doi:10.1016/8756-3282(93)90186-e · Cited by 29 · see citing works

The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the resorptive function of osteoclasts of known nuclear number

Piper, K., BOYDE, A., & Jones, S. J. (1994) · Calcified Tissue International · doi:10.1007/bf00316291 · Cited by 22 · see citing works

Generation and activity of equine osteoclasts in vitro: effects of the bisphosphonate pamidronate (APD)

Gray, A., Davies, M., & Jeffcott, L. B. (2002) · Research in Veterinary Science · doi:10.1053/rvsc.2001.0523 · Cited by 19 · see citing works

Relationship between bisphosphonate concentration and osteoclast activity and viability

Rowe, D. J., Etre, L. A., Lovdahl, M. J., & Pietrzyk, D. J. (1999) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-999-0112-7 · Cited by 17 · see citing works

Influence of Bisphosphonate Treatment on Medullary Macrophages and Osteoclasts: An Experimental Study

Escudero, N. D., & Mandalunis, P. (2012) · Bone Marrow Research · doi:10.1155/2012/526236 · Cited by 16 · see citing works

The RANKL Inhibitor Osteoprotegerin (OPG) Causes Greater Suppression of Bone Resorption and Hypercalcemia Compared to Bisphosphonates in Two Models of Humoral Hypercalcemia of Malignancy

Morony, S., Warmington, K. S., Adamu, S., Asuncion, F., Geng, Z., Grisanti, M. S., Tan, H. L. E., Capparelli, C., Starnes, C. O., Dunstan, C. R., et al. (2005) · Cited by 13 · see citing works

Pamidronate prevents bone loss associated with carrageenan arthritis by reducing resorptive activity but not recruitment of osteoclasts

Moran, E. L., Fornasier, V., & Bogoch, E. R. (2000) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100180605 · Cited by 8 · see citing works

Hypercalcaemia in patients with cancer: aetiology and treatment

Heys, S. D., Smith, I. C., & Eremin, O. (1998) · European Journal of Surgical Oncology · doi:10.1016/s0748-7983(98)91589-x · Cited by 7 · see citing works

Effects of bisphosphonate (pamidronate) on bone resorption resulting from metastasis of a squamous cell carcinoma: Report of an autopsy case and evaluation of bone resorbing activity in an experimental animal model

Hiraga, T., Takada, M., Nakajima, T., & Ozawa, H. (1996) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(96)90492-9 · Cited by 7 · see citing works

Effects of the antihypercalcemic drugs gallium nitrate and pamidronate on hormone release of pathologic human parathyroid cells

Ridefelt, P., Gylfe, E., Åkerström, G., & Rastad, J. (1995) · Surgery · doi:10.1016/s0039-6060(05)80230-2 · Cited by 6 · see citing works

Drug Therapy of Hypercalcemia Due to Malignancy

Raue, F., & Pecherstorfer, M. (1994) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-85073-8_9 · Cited by 5 · see citing works

Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption

Rogers, M. J., & Russell, R. G. G. (1996) · Medical intelligence unit · doi:10.1007/978-3-662-22505-9_7 · Cited by 4 · see citing works

New insights into the mechanisms of bisphosphonates action

Tsetsenekou, E., & Kalyvas, D. (2010) · Cited by 1 · see citing works

The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the resorptive function of osteoclasts of known nuclear number

Piper, K., BOYDE, A., & Jones, S. J. (1994) · Calcified Tissue International · doi:10.1007/bf00316291 · Cited by 22 · see citing works

P25. Toxicity of (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (APD) to mouse osteoclasts in vitro and in vivo

Marshall, M. E., Wiseman, J., Wilson, A., & Davie, M. (1988) · Bone · doi:10.1016/8756-3282(88)90091-9 · Cited by 1 · see citing works

Osteoclast Recruitment in Mice is Stimulated by (3-Amino-l-Hydroxypropylidene)-l,l-Bisphosphonate

Marshall, M. J. E., Holt, I., William, M., Davie, J. R., Jones, R. H., & Hunt, A. (1993)

Osteoclast recruitment in mice is stimulated by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate.

Marshall, M. J., Holt, I., & John Davie, M. W. (1993) · Calcified Tissue International · doi:10.1007/bf00675622 · Cited by 37 · see citing works

12. Low concentrations of APD (3-amino-1-hydroxypropylidene-1-1-diphosphonic acid) affect both osteoclast recruitment and human osteoblast-like cells in vitro

Braidman, I. P., & Evans, C. (1991) · Bone · doi:10.1016/8756-3282(91)90108-u · Cited by 1 · see citing works