The effects of two diphosphonates on bone metabolism in the rat.
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Bisphosphonates have a different mechanism of action and can be associated with normal or increased osteoclast numbers despite clear antiresorptive effects.
“In contrast, bisphosphonates have a different mechanism of action that can be associated with normal or even increased osteoclast numbers despite clear antiresorptive effects (129 -138).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [132]
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Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Effects of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate on mouse osteoclasts.
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- Authors
- Evans, R. A., Baylink, D. J., & Wergedal, J.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Baylink, D.J.
- Venue
- Metabolic Bone Disease and Related Research
- Publisher
- Elsevier BV
- Published
- 1979-01
- Volume
- 2
- Issue
- 1
- Pages
- 39-48
- ISSN
- 0221-8747 (ISSN-L)
- OpenAlex
- W2031930092
- Cited by
- 30
- References
- 33
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Bone Disease and Related Research (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- diphosphonates, ethane-1-hydroxy-1,1-diphosphonate, dichloromethylene diphosphonate, bone resorption, bone formation, bone mineralization, osteoclasts, parathyroid hormone, serum calcium and phosphorus, low-dose effects, weanling rats, bone metabolism, dose-response relationship
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