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Cited by 608

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates

Open access
Dr. Slemenda, Charles W., Christian, Joe C., Williams, Christopher J., Norton, James A., Johnston, C. Conrad·1991·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.5650060606
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Abstract

We estimated genetic effects on bone density in pre- and postmenopausal twins and critically considered the assumptions of the twin model. Bone mass in the radius, lumbar spine, and hip, anthropometric measurements, usual calcium and caffeine intake, tobacco and alcohol use, number of pregnancies and live births, menstrual history, usual physical activity, and medical history were measured in a volunteer sample of 171 twin pairs [124 monozygotic (MZ) and 47 dizygotic (DZ)], aged 25–80, free of diseases known to affect bone mass or mineral metabolism. At all skeletal sites, MZ intraclass correlations exceeded DZ correlations for both pre- and postmenopausal women, yielding highly significant estimates of heritability for bone mass. Adjustments for height, age, and environmental characteristics did not reduce the heritability estimates. However, many of these estimates were unrealistically high, suggesting some violation(s) of the assumptions of the twin model. Thus, the familial resemblance in bone mass is due primarily to genetic effects at all skeletal sites and at all ages, although the importance of genetic effects is diminished with aging, as evidenced by increasing within-MZ pair variability in older women. Because of failures in the assumptions of the twin model, however, particularly the greater MZ environmental similarity and the probability of gene interaction, heritability estimates are probably too high and require cautious interpretation.

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Metadata

Authors
Dr. Slemenda, C. W., Christian, J. C., Williams, C. J., Norton, J. A., & Johnston, C. C.
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
1991-06-01
Volume
6
Issue
6
Pages
561-567
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.5650060606
OpenAlex
W2001024743
Cited by
608
References
10
FWCI
19.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. https://app.cochat.ai/papers/10.1002/jbmr.5650060606
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Dr. Slemenda, C. W., Christian, J. C., Williams, C. J., Norton, J. A., & Johnston, C. C. (1991). Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650060606

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.