The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Association of bone mineral density with polymorphism of the estrogen receptor gene
Abstract
PvuII and XbaI restriction fragment length polymorphisms (RFLPs) of the estrogen receptor (ER) gene and its relation to bone mineral density (BMD) were examined in 238 postmenopausal healthy women aged 45–91 years (66.3 ± 0.6 years, mean ± standard error of the mean [SEM]) in Japan. The RFLPs were represented as Pp (PvuII) and Xx (XbaI), with capital letters signifying the absence of and small letters the presence of restriction sites. In the PPxx genotype (n = 18), Z score values of BMD were significantly lower than those for other genotypes (n = 220) (lumbar spine, −0.746 vs. −0.065 [p = 0.022]; total body, −0.482 vs. 0.308 [p = 0.002]). We classified the subjects into three genotypes with allelic haplotype: homozygote of the Px haplotype was expressed as the 11 genotype, heterozygote of the Px haplotype as the 10 genotype, and the one lacking the Px haplotype as the 00 genotype. The PpXx genotype was not included in this analysis because the allelic haplotypes are uncertain. The Px haplotype was associated with a low BMD in postmenopausal women (Z score for the lumbar spine, −0.746 vs. −0.279 vs. 0.083, for the 11, 10, 00 genotypes, respectively [p = 0.029]; Z score for the total body, −0.482 vs. 0.164 vs. 0.427, respectively [p = 0.003]). We suggest that some variation of the ER gene linked to these RFLPs is associated with low BMD and that this at least partly explains the cause of postmenopausal osteoporosis in Japanese women.
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Cites
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
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Cited by
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
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Endometriosis: The pathophysiology as an estrogen-dependent disease
Kitawaki, J., Kado, N., Ishihara, H., Koshiba, H., Kitaoka, Y., & Honjo, H. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00260-1 · Cited by 370
Adenomyosis: the pathophysiology of an oestrogen-dependent disease
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Glycohemoglobin results in samples with hemoglobin C or S trait: a comparison of four test systems
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Metadata
- Authors
- Kobayashi, S., Inoue, S., Dr. Hosoi, T., Ouchi, Y., Shiraki, M., & Orimo, H.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03-01
- Volume
- 11
- Issue
- 3
- Pages
- 306-311
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2063518962
- Cited by
- 555
- References
- 24
- FWCI
- 38.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kobayashi, S., Inoue, S., Dr. Hosoi, T., Ouchi, Y., Shiraki, M., & Orimo, H. (1996). Association of bone mineral density with polymorphism of the estrogen receptor gene. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650110304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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