Cited by 157Bone Metabolism and DiseasesTGF-β signaling in diseasesProtease and Inhibitor Mechanisms

The DOI matches its Crossref record; 59 of the 61 references it cites were found in a registry or an index.

Osteoclast synthesis and secretion and activation of latent transforming growth factor β

Oursler, Merry Jo·1994·Journal of Bone and Mineral Research

Open this paper in CoChat — free account

Abstract

The coupling of bone resorption and formation suggests that autocrine and paracrine factors are produced and released within the local bone environment. Since osteoblasts secrete latent transforming growth factor β (TGF-β), and osteoclasts can activate this latent complex, one candidate paracrine coupling factor is TGF-β. To examine whether TGF-β is also a potential osteoclast-derived autocrine and paracrine factor, highly purified avian osteoclasts were examined for synthesis of TGF-β and the mechanism by which osteoclasts activate the latent TGF-β complex was investigated. TGF-β protein production was measured within 4 h of culture in osteoclast-conditioned media using growth factor inhibition of CCL-64 cells and verified by blocking effects with anti-TGF-β antibodies. Synthesis of TGF-β was confirmed by northern blotting and metabolic labeling. Northern blots of total RNA revealed that osteoclasts expressed the mRNA for TGF-β2, β3, and β4. Biosynthetic studies suggest that TGF-β2 was the principle form secreted in culture. Nearly all the TGF-β that was secreted had been activated by the osteoclasts. When presented with exogenous latent TGF-β, osteoclasts activated latent TGF-β from a variety of sources. Furthermore, osteoclast-conditioned media retained the ability to activate latent TGF-β during cell-free incubations at 37°C. Osteoclast-mediated activation was inhibited by proteinase inhibitors, weak base treatment of the cells, or disruption of the cytoskeletal network. These data suggest that osteoclasts may secrete proteinases into the extracellular milieu to activate latent TGF-β and that TGF-β may be an autocrine factor involved in regulating osteoclast activity.

Integrity signals

Registry

Crossref · 10.1002/jbmr.5650090402

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
[41] Cathepsin B, cathepsin H, and cathepsin L
Barrett, A. J., & Kirschke, H. (1981) · Methods in Enzymology · doi:10.1016/s0076-6879(81)80043-2 · Cited by 1,698
Peptide Growth Factors and Their Receptors
Arai, K., Battey, J. F., Sporn, M. B., & Roberts, A. B. (1991) · Medical Entomology and Zoology · Cited by 1,225
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.
Lyons, R. M., Keski‐Oja, J., & Moses, H. L. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.5.1659 · Cited by 969
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.
Sato, Y., & Rifkin, D. B. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.309 · Cited by 908
Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1
Silver, I. A. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90191-7 · Cited by 902
Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.
Lyons, R. M., Gentry, L. E., Purchio, A. F., & Moses, H. L. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1361 · Cited by 737
Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.
Pelton, R. W., Saxena, B., Jones, M., Moses, H. L., & Gold, L. I. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.4.1091 · Cited by 671
Receptors for the TGF-β family
Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90627-o · Cited by 641

Show all 61 references

Research works printed but not linked: 5

Noda, 1988, TGF-β regulation of alkaline phosphatase (AP) gene expression in rat osteosarcoma (ROS 17/2.8) cells, Calcif Tissue Int, 42, A–34
Pfeilschifter, 1988, Transforming growth factor beta (TGF-beta) inhibits bone resorption in fetal rat long bones, Calcif Tissue Int, 42, A–34
Roberts, 1991, Ciba Foundation Symposium, 157, 7
Chambers, 1991, Bone, Vol. 2, The Osteoclast, 2, 141
Bonewald, 1990, Role of transforming growth factor-beta in bone remodeling, Clin Orthop, 250, 261, 10.1097/00003086-199001000-00036 · DOI

Sorted by citations

Making sense of latent TGFβ activation
Annes, J. P., Munger, J. S., & Rifkin, D. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,624
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
Cell biology of the osteoclast
Roodman, G. D. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00061-2 · Cited by 583
Latent transforming growth factor-β: Structural features and mechanisms of activation
Munger, J. S., Harpel, J. G., Gleizes, P., Mazzieri, R., Nunes, I., & Rifkin, D. B. (1997) · Kidney International · doi:10.1038/ki.1997.188 · Cited by 513
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation
Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar-Gutter, W., Saftig, P., & Beertsen, W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.77 · Cited by 411
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts
Dallas, S. L., Rosser, J. L., Mundy, G. R., & Bonewald, L. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111663200 · Cited by 414
Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix
Munger, J. S., & Sheppard, D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005017 · Cited by 372
Latent TGF-β Binding Proteins: Extracellular Matrix Association and Roles in TGF-β Activation
Hyytiäinen, M. M., Penttinen, C., & Keski‐Oja, J. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490460933 · Cited by 351
Association of a Polymorphism of the Transforming Growth Factor-β1 Gene with Genetic Susceptibility to Osteoporosis in Postmenopausal Japanese Women
Yamada, Y., Miyauchi, A., Goto, J., Takagi, Y., Okuizumi, H., Kanematsu, M., Hase, M., Takai, H., Harada, A., & Ikeda, K. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.10.1569 · Cited by 318
Implant Surface Characteristics Modulate Differentiation Behavior of Cells in the Osteoblastic Lineage
Schwartz, Z., Lohmann, C. H., Oefinger, J., Bonewald, L. F., Dean, D. D., & Boyan, B. D. (1999) · Advances in Dental Research · doi:10.1177/08959374990130011301 · Cited by 308
Role of active and latent transforming growth factor β in bone formation
Bonewald, L. F., & Dallas, S. L. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550312 · Cited by 297
THE BIOLOGY OF THE GROWTH PLATE
Ballock, R. T., & O’Keefe, R. J. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200304000-00021 · Cited by 277
Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned
Drake, M. T., Clarke, B. L., Oursler, M. J., & Khosla, S. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1114 · Cited by 291
Self-citation
Osteoblastic Responses to TGF-β during Bone Remodeling
Erlebacher, A., Filvaroff, E. H., Ye, J., & Derynck, R. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.7.1903 · Cited by 234
A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women
Langdahl, B. L., Knudsen, J., Jensen, H. K., Gregersen, N. V., & Eriksen, E. F. (1997) · Bone · doi:10.1016/s8756-3282(96)00363-8 · Cited by 216
Basic FGF mediates an immediate response of articular cartilage to mechanical injury
Vincent, T. L., Hermansson, M., BOLTON, M. C., Wait, R., & Saklatvala, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122033199 · Cited by 212
The insulin-like growth factor system and the coupling of formation to resorption
Hayden, J. M., Mohan, S., & Baylink, D. J. (1995) · Bone · doi:10.1016/8756-3282(95)00186-h · Cited by 199
Osteocytes inhibit osteoclastic bone resorption through transforming growth factor‐β: Enhancement by estrogen*
Heino, T. J., Hentunen, T. A., & Väänänen, H. K. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10109 · Cited by 191
Mechanisms Involved in Osteoblast Response to Implant Surface Morphology
Boyan, B. D., Lohmann, C. H., Dean, D. D., Sylvia, V. L., Cochran, D. L., & Schwartz, Z. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.357 · Cited by 185
Roles of stromal cell RANKL, OPG, and M‐CSF expression in biphasic TGF‐β regulation of osteoclast differentiation
Karst, M., Gorny, G., Galvin, R. J. S., & Oursler, M. J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20036 · Cited by 184
Self-citation
Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone
Mohammad, K. S., Chen, C. G., Balooch, G., Stebbins, E. G., McKenna, C. R., Davis, H., Niewolna, M., Peng, X., Nguyen, D. H., Ionova-Martin, S. S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005275 · Cited by 181
TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
Gingery, A., Bradley, E. W., Pederson, L. G., Ruan, M. M., Horwood, N. J., & Oursler, M. J. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.006 · Cited by 175
Self-citation
The activin A‐follistatin system: potent regulator of human extracellular matrix mineralization
Eijken, M., Swagemakers, S. M. A., Koedam, M., Steenbergen, C., Derkx, P., Uitterlinden, A. G., van der Spek, P. J., Visser, J. A., de Jong, F. H., Pols, H. A. P., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8080com · Cited by 175
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis
Furman, B. D., Mangiapani, D., Zeitler, E. M., Bailey, K. N., Horne, P. H., Huebner, J. L., Kraus, V. B., Guilak, F., & Olson, S. A. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4591 · Cited by 171
Physiology and pathophysiology of the growth plate
Ballock, R. T., & O’Keefe, R. J. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10014 · Cited by 155
Molecular mechanisms underlying osteoclast formation and activation
Troen, B. R. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00069-x · Cited by 154
Transforming Growth Factor-β Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression
Karsdal, M. A., Hjorth, P., Henriksen, K., Kirkegaard, T., Nielsen, K. L., Lou, H., Delaissé, J., & Foged, N. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303905200 · Cited by 137
TGF-β Inhibition Restores Terminal Osteoblast Differentiation to Suppress Myeloma Growth
Takeuchi, K., Abe, M., Hiasa, M., Oda, A., Amou, H., Kido, S., Harada, T., Tanaka, O., Miki, H., Nakamura, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009870 · Cited by 138
The stimulation of an osteogenic response by classical monocyte activation
Omar, O., Granéli, C., Ekström, K. M., Karlsson, C., Johansson, A., Lausmaa, J., Wexell, C. L., & Thomsen, P. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.055 · Cited by 136
TGF-β Enhances Osteoclast Differentiation in Hematopoietic Cell Cultures Stimulated with RANKL and M-CSF
Galvin, R. J. S., Gatlin, C. L., Horn, J. W., & Fuson, T. R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1632 · Cited by 132
Androgens regulate bone resorption activity of isolated osteoclasts in vitro
Pederson, L., Kremer, M., Judd, J., Pascoe, D., Spelsberg, T. C., Riggs, B. L., & Oursler, M. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.505 · Cited by 123
Self-citation
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Mazur, C. M., Woo, J. J., Yee, C. S., Fields, A. J., Acevedo, C., Bailey, K. N., Kaya, S., Fowler, T. W., Lotz, J. C., Dang, A. C., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0070-y · Cited by 120
Endogenous Production of TGF-β Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-κB Ligand and Macrophage-Colony- Stimulating Factor
Kaneda, T., Nojima, T., Nakagawa, M., Ogasawara, A., Kaneko, H., Sato, T., Mano, H., Kumegawa, M., & Hakeda, Y. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4254 · Cited by 120
Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-β1 (TGF-β1)
Hintze, V., Miron, A., Moeller, S. J., Schnabelrauch, M., Wiesmann, H., Worch, H., & Scharnweber, D. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.03.021 · Cited by 116
Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures
Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J., & Roodman, G. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6374 · Cited by 107
Smad4 is required for maintaining normal murine postnatal bone homeostasis
Tan, X., Weng, T., Zhang, J., Jian, W., Li, W., Wan, H., Lan, Y., Cheng, X., Hou, N., Liu, H., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03466 · Cited by 108
Osteoclast Deficiency Results in Disorganized Matrix, Reduced Mineralization, and Abnormal Osteoblast Behavior in Developing Bone
Dai, X.-M., Zong, X.-H., Akhter, M. P., & Stanley, E. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040514 · Cited by 105
Latent transforming growth factor-beta is produced by chondrocytes and activated by extracellular matrix vesicles upon exposure to 1,25-(OH)2D3.
Boyan, B. D., Schwartz, Z., Park-Snyder, S., Dean, D. D., Yang, F., Twardzik, D. R., & Bonewald, L. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46938-4 · Cited by 103
Transforming Growth Factor-β Up-regulates the β5Integrin Subunit Expression via Sp1 and Smad Signaling
Lai, C.-F., Feng, X., Nishimura, R., Teitelbaum, S. L., Avioli, L. V., Ross, F. P., & Cheng, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002131200 · Cited by 101
Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering
Bai, Y., Yin, G., Huang, Z., Liao, X., Chen, X., Yao, Y., & Pu, X. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.04.001 · Cited by 100
Activation of Latent Transforming Growth Factor β1 by Stromelysin 1 in Extracts of Growth Plate Chondrocyte-Derived Matrix Vesicles
Maeda, S., Dean, D. D., Gay, I. C., Schwartz, Z., & Boyan, B. D. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.7.1281 · Cited by 95
Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors
Ota, K., Quint, P. S., Weivoda, M. M., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Bone · doi:10.1016/j.bone.2013.07.023 · Cited by 92
Self-citation
Biphasic effects of transforming growth factor β on bone morphogenetic protein–induced osteoblast differentiation
de Gorter, D. J. J., van Dinther, M., Korchynskyi, O., & ten Dijke, P. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.313 · Cited by 89
Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis
JÓNSSON, T., Steinsson, K., Jónsson, H., Geirsson, Á. J., Thorsteinsson, J., & Valdimarsson, H. (1998) · Rheumatology International · doi:10.1007/s002960050069 · Cited by 89
TGF-β Induces Wnt10b in Osteoclasts From Female Mice to Enhance Coupling to Osteoblasts
Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Endocrinology · doi:10.1210/en.2013-1272 · Cited by 86
Self-citation
Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation
Weivoda, M. M., Ruan, M. M., Pederson, L. G., Hachfeld, C. M., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2586 · Cited by 83
Self-citation
Osteoclast Activated FoxP3+ CD8+ T-Cells Suppress Bone Resorption in vitro
Buchwald, Z. S., Kiesel, J. R., DiPaolo, R. J., Pagadala, M. S., & Aurora, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038199 · Cited by 84
Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway
Karsdal, M. A., Fjording, M. S., Foged, N. T., Delaissé, J.-M., & Lochter, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008738200 · Cited by 81
Osteoblast migration in vertebrate bone
Thiel, A., Reumann, M. K., Boskey, A. L., Wischmann, J., von Eisenhart‐Rothe, R., & Mayer‐Kuckuk, P. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12345 · Cited by 79
Estrogen modulation of osteoclast lysosomal enzyme secretion
Kremer, M., Judd, J., Rifkin, B. R., Auszmann, J. M., & Oursler, M. J. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240570211 · Cited by 79
Self-citation
Regulation of postnatal bone homeostasis by TGFβ
Tang, S. Y., & Alliston, T. N. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2012.255 · Cited by 77
RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors
Yao, Z., Lei, W., Duan, R., Li, Y., Luo, L., & Boyce, B. F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.771816 · Cited by 76
Role of TGF-β in breast cancer bone metastases
Chiechi, A., Waning, D. L., Stayrook, K. R., Buijs, J. T., Guise, T. A., & Mohammad, K. S. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.410a4003 · Cited by 76
Hepatic Osteodystrophy—Molecular Mechanisms Proposed to Favor Its Development
Ehnert, S., Aspera-Werz, R. H., Ruoß, M., Dooley, S., Hengstler, J. G., Nadalin, S., Relja, B., Badke, A., & Nussler, A. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102555 · Cited by 75
Novel insights into the coupling of osteoclasts and resorption to bone formation
Durdan, M., Azaria, R. D., & Weivoda, M. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.008 · Cited by 69
Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw
Manzano‐Moreno, F. J., Ramos‐Torrecillas, J., Melguizo‐Rodríguez, L., Montes, R. I., Ruíz, C., & García‐Martínez, O. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.22627 · Cited by 67
Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β
Alabanza, L. M., Xiong, Y., Vu, B. K., Webster, B., Wu, D., Hu, P., Zhu, Z., Dropulić, B., Dash, P., & Schneider, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.832645 · Cited by 63
Effects of transforming growth factor beta (TGFβ) and 1,25 dihydroxyvitamin D3 on the function, cytochemistry and morphology of normal human osteoblast-like cells
Ingram, R. T., Bonde, S. K., Riggs, B. L., & Fitzpatrick, L. A. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5520153.x · Cited by 60
Growth Regulatory Factors and Bone
Mundy, G. R., Chen, D., Zhao, M., Dallas, S. L., Xu, C., & Harris, S. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1010015309973 · Cited by 57
PTHrP Expression in Chondrocytes, Regulation by TGF-β, and Interactions between Epiphyseal and Growth Plate Chondrocytes
Pateder, D. B., Rosier, R. N., Schwarz, E. M., Reynolds, P. R., Puzas, J. E., D’Souza, M., & O’Keefe, R. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4860 · Cited by 57
TGF β : A player on multiple fronts in the tumor microenvironment
Čaja, F., & Vannucci, L. E. (2014) · Journal of Immunotoxicology · doi:10.3109/1547691x.2014.945667 · Cited by 56
Transforming Growth Factor-β Induces Osteoclast Ruffling and Chemotaxis: Potential Role in Osteoclast Recruitment
Pilkington, M. F., Sims, S. M., & Dixon, S. J. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.7.1237 · Cited by 56
Breast cancer bone metastasis and current small therapeutics
Cicek, M., & Oursler, M. J. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9035-x · Cited by 55
Self-citation
Differential Cytotoxicity of Cord Blood and Bone Marrow–Derived Natural Killer Cells
Gardiner, C. M., Meara, A. O., & Reen, D. J. (1998) · Blood · doi:10.1182/blood.v91.1.207 · Cited by 55
T cell suppression by osteoclasts in vitro
Grassi, F., Manferdini, C., Cattini, L., Piacentini, A., Gabusi, E., Facchini, A., & Lisignoli, G. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22411 · Cited by 54
Transforming Growth Factor-β1 Gene Polymorphism, Bone Turnover, and Bone Mass in Italian Postmenopausal Women
Bertoldo, F., D’Agruma, L., Furlan, F., Colapietro, F., Lorenzi, M. T., Maiorano, N., Iolascon, A., Zelante, L., LoCascio, V., & Gasparini, P. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.4.634 · Cited by 50
Association of Transforming Growth Factor β1 Genotype with Therapeutic Response to Active Vitamin D for Postmenopausal Osteoporosis
Yamada, Y., Harada, A., Hosoi, T., Miyauchi, A., Ikeda, K., Ohta, H., & Shiraki, M. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.3.415 · Cited by 50
Mechanobiology of TGFβ signaling in the skeleton
Rys, J. P., Monteiro, D. A., & Alliston, T. N. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.02.002 · Cited by 51
Tumor necrosis factor-alpha and transforming growth factor-beta1 in chronic periapical lesions
Danin, J., Linder, L. E., Lundqvist, G., & Andersson, L. (2000) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2000.108958 · Cited by 44
Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production
Robinson, J. A., Riggs, B. L., Spelsberg, T. C., & Oursler, M. J. (1996) · Endocrinology · doi:10.1210/en.137.2.615 · Cited by 44
Self-citation
Regulation of Osteocalcin Production and Bone Resorption by 1,25-Dihydroxyvitamin D3 in Mouse Long Bones: Interaction with the Bone-Derived Growth Factors TGF-β and IGF-I
Staal, A., Geertsma-Kleinekoort, W. M. C., van den Bemd, G. J. C. M., Buurman, C. J., Birkenhäger, J. C., Pols, H. A. P., & van Leeuwen, J. P. T. M. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.1.36 · Cited by 43
Characterization of Runx2 phosphorylation sites required for TGF‐β1‐mediated stimulation of matrix metalloproteinase‐13 expression in osteoblastic cells
Balasubramanian, A., Vairamani, M., Partridge, N. C., & Selvamurugan, N. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25964 · Cited by 43
Association of a Leu10→Pro polymorphism of the transforming growth factor-β1 with genetic susceptibility to osteoporosis and spinal osteoarthritis
Yamada, Y. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00131-7 · Cited by 43
Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK / RANKL / OPG Regulation
Lennerås, M., Palmquist, A., Norlindh, B., Emanuelsson, L., Thomsen, P., & Omar, O. (2014) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12276 · Cited by 42
Cytokines as Mediators of Pain‐Related Process in Breast Cancer
Panis, C., & Pavanelli, W. R. (2015) · Mediators of Inflammation · doi:10.1155/2015/129034 · Cited by 42
Cytokine Regulation of Bone Cell Differentiation
Melissa, A. T., Guise, T. A., & Roodman, D. (1996) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60407-0 · Cited by 41
Transforming Growth Factor-β Coordinately Induces Suppressor of Cytokine Signaling 3 and Leukemia Inhibitory Factor to Suppress Osteoclast Apoptosis
Ruan, M. M., Pederson, L. G., Bradley, E. W., Bamberger, A., & Oursler, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-0813 · Cited by 38
Self-citation
Osteoclasts: Other functions
Park‐Min, K., & Lorenzo, J. A. (2022) · Bone · doi:10.1016/j.bone.2022.116576 · Cited by 39
Transforming Growth Factor-β
Dallas, S. L., Alliston, T. N., & Bonewald, L. F. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00067-7 · Cited by 36
1α,25-Dehydroxyvitamin D3 Synergism toward Transforming Growth Factor-β1-induced AP-1 Transcriptional Activity in Mouse Osteoblastic Cells via Its Nuclear Receptor
Takeshita, A., Imai, K., Kato, S., Kitano, S., & Hanazawa, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14738 · Cited by 35
Osteoclasts Secrete the Chemotactic Cytokine Mim-1
Falany, M. L., Thames, A. M., McDonald, J. M., Blair, H. C., McKenna, M. A., Moore, R. E., Young, M. K., & Williams, J. P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4307 · Cited by 35
Bone graft proteins influence osteoconduction: A titanium chamber study in rats
Aspenberg, P., Tägil, M., Kristensson, C., & Lidin, S. (1996) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679609002335 · Cited by 35
Association of polymorphisms of the transforming growth factor-ß1 gene with genetic susceptibility to osteoporosis
Yamada, Y. (2001) · Pharmacogenetics · doi:10.1097/00008571-200112000-00004 · Cited by 34
TGF-β1 secretion of ROS-17/2.8 cultures on NiTi implant material
Kapanen, A. I., Kinnunen, A., Ryhänen, J., & Tuukkanen, J. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00023-6 · Cited by 34
Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption.
Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D., & Reddy, S. V. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2667 · Cited by 32
The Induction of Bone Formation: The Translation Enigma
Klar, R. M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00074 · Cited by 31
PTHrP expression in chick sternal chondrocytes is regulated by TGF‐β through Smad‐mediated signaling
Pateder, D. B., Ferguson, C. M., Ionescu, A. M., Schwarz, E. M., Rosier, R. N., Puzas, J. E., & O’Keefe, R. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1118 · Cited by 30
Properties of bisphosphonates in the 13762 rat mammary carcinoma model of tumor-induced bone resorption.
Alvarez, E., Westmore, M. S., Galvin, R. J. S., Clapp, C. L., Considine, E. L., Smith, S. J., Keyes, K. A., Iversen, P. W., Delafuente, D. M., Sulaimon, S. S., et al. (2003) · PubMed · Cited by 29
Formation of osteoclast‐like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony‐stimulating factor
Tjoa, S., de Vries, T. J., Schoenmaker, T., Kelder, A., Loos, B. G., & Everts, V. E. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01241.x · Cited by 28
The role of TGFβ receptor 1-smad3 signaling in regulating the osteoclastic mode affected by fluoride
Yu, H., Jiang, N., Yu, X., Zhao, Z.-T., Zhang, X., & Xu, H. J. (2017) · Toxicology · doi:10.1016/j.tox.2017.11.009 · Cited by 26
Simulation of bone resorption-repair coupling in vitro
Jones, S. J., Gray, C., & BOYDE, A. (1994) · Anatomy and Embryology · doi:10.1007/bf00187292 · Cited by 28
Beyond resorption: osteoclasts as drivers of bone formation
Xiang, Q., Li, L., Ji, W., Gawlitta, D., Walboomers, X. F., & van den Beucken, J. J. J. P. (2024) · Cell Regeneration · doi:10.1186/s13619-024-00205-x · Cited by 29
Acid bone lysate activates TGFβ signalling in human oral fibroblasts
Strauß, F. J., Stähli, A., Beer, L., Mitulović, G., Gilmozzi, V., Haspel, N., Schwab, G., & Gruber, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-34418-3 · Cited by 25
Mitogen activated protein kinase‐dependent inhibition of osteocalcin gene expression by transforming growth factor‐β1
Kwok, S., Partridge, N. C., Srinivasan, N., Nair, S. V., & Selvamurugan, N. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21991 · Cited by 25
Alterations of fracture healing in the diabetic condition.
Kagel, E. M., & Einhorn, T. A. (1996) · PubMed Central · Cited by 24
Galectin-1 in cartilage: Expression, influence on chondrocyte growth and interaction with ECM components
Marsich, E., Mozetic, P., Ortolani, F., Contin, M., Marchini, M., Vetere, A., Pacor, S., Semeraro, S., Vittur, F., & Paoletti, S. (2008) · Matrix Biology · doi:10.1016/j.matbio.2008.04.003 · Cited by 24
Effects of Retinol on Activation of Latent Transforming Growth Factor-β by Isolated Osteoclasts*
Bonewald, L. F., Oreffo, R. O. C., Lee, C. H., Park-Snyder, S., Twardzik, D. R., & Mundy, G. R. (1997) · Endocrinology · doi:10.1210/endo.138.2.4944 · Cited by 24
Cell–cell communication in bone development and whole-body homeostasis and pharmacological avenues for bone disorders
Park, Y. E., Musson, D. S., Naot, D., & Cornish, J. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.04.001 · Cited by 25

Authors: Oursler, M. J.
Affiliations: Mayo Clinic (US)
Corresponding author: Oursler, Merry Jo
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 1994-04-01
Volume: 9
Issue: 4
Pages: 443-452
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1002/jbmr.5650090402
OpenAlex: W2043164695
Cited by: 153
References: 61
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AR4114-01A1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: osteoclasts, TGF-beta activation, TGF-beta secretion, autocrine regulation, paracrine signaling, bone resorption, bone formation, proteolytic enzymes, cytoskeleton, TGF-beta2, TGF-beta mRNA expression
MeSH terms: Animals, Bone Resorption, Cells, Cultured, Chickens, Osteoclasts, Osteogenesis, Protease Inhibitors, RNA, Messenger, Transforming Growth Factor beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Osteoclast synthesis and secretion and activation of latent transforming growth factor β

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks