Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF‐9/MAPK/Smad pathway
Abstract
Higher expression of growth differentiation factor‐9 (GDF‐9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF‐9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF‐9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF‐9 was opposite to that of TGF‐β1. The bioactivity difference between GDF‐9 and TGF‐β1 could be explained by the different phosphorylated sites on the downstream Smad2/3. Moreover, asiaticoside could inhibit GDF‐9‐induced activation of MAPKs and Smad pathway in KFs. In conclusion, GDF‐9 enhanced the invasive growth of KFs, which was achieved by phosphorylation of Smad 2/3 at the linker region through activation of MAPKs pathway. Asiaticoside hindered the invasive growth of KFs by inhibiting the GDF‐9/MAPK/Smad pathway.
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Asiaticoside inhibits invasive growth of KFs by inhibiting GDF-9/MAPK/Smad pathway.
“Asiaticoside is capable of inhibiting this invasive growth of KFs by inhibiting the GDF‐9/MAPK/Smad pathway.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [97]
Overexpression of GDF-9 in keloids enhances proliferation, migration and invasion of keloid fibroblasts due to phosphorylation of Smad 2/3 proteins through activation of MAPK pathway.
“The overexpression of growth differentiation factor‐9 (GDF‐9) in keloids enhances the proliferation, migration and invasion of keloid fibroblasts due to the phosphorylation of Smad 2/3 proteins through activation of the MAPK pathway.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [97]
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Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
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- Authors
- Wu, X., Bian, D., Dou, Y., Gong, Z., Tan, Q., Xia, Y., & Dai, Y.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing Normal University (CN)
- Nanjing Drum Tower Hospital (CN)
- Corresponding author
- Xia, Yufeng
- Dai, Yue
- Venue
- Journal of Biochemical and Molecular Toxicology
- Publisher
- Wiley
- Published
- 2017-03-27
- Volume
- 31
- Issue
- 8
- ISSN
- 0887-2082 (ISSN-L)
- 1095-6670
- 1099-0461
- OpenAlex
- W2600290844
- Cited by
- 31
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biochemical and Molecular Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30973915)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- asiaticoside, keloids, keloid fibroblasts, growth differentiation factor 9, Smad2/3 phosphorylation, MAPK signaling, fibroblast invasion, fibroblast proliferation and migration, TGF-β1, collagen expression, keloid pathogenesis
- MeSH terms
- Adolescent, Adult, Cell Movement, Female, Fibroblasts, Humans, Keloid, Phosphorylation, Triterpenes, MAP Kinase Signaling System, Cell Proliferation, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta1, Growth Differentiation Factor 9
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