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Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

Ghosh, Arundhati, Heston, Warren D.W.·2004·Journal of Cellular Biochemistry

Abstract

Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an important marker as well as a large extracellular target of imaging agents. PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides. PSMA has two unique enzymatic functions, folate hydrolase and NAALADase and found to be recycled like other membrane bound receptors through clathrin coated pits. The internalization property of PSMA leads one to consider the potential existence of a natural ligand for PSMA. In this review we have discussed the regulation of PSMA expression within the cells, and significance of its expression in prostate cancer and metastasis. © 2003 Wiley‐Liss, Inc.

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Crossref · 10.1002/jcb.10661

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Metadata

Authors
Ghosh, A., & Heston, W. D. W.
Venue
Journal of Cellular Biochemistry
Publisher
Wiley
Published
2003-10-07
Volume
91
Issue
3
Pages
528-539
ISSN
  • 0730-2312 (ISSN-L)
  • 1097-4644
OpenAlex
W2155421560
Cited by
878
References
2
FWCI
8.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. https://app.cochat.ai/papers/10.1002/jcb.10661
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Ghosh, A., & Heston, W. D. W. (2004). Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.10661

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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