Cited by 285Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentBreast Cancer Treatment Studies

High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer

Minner, Sarah, Wittmer, Corinna, Graefen, Markus, Salomon, Georg, Steuber, Thomas, Haese, Alexander, Huland, Hartwig, Bokemeyer, Carsten +8 more·2011·The Prostate

Abstract

BACKGROUND: Prostate specific membrane antigen (PSMA) is a suggested target for antibody‐based therapy of prostate cancer potentially involved in the regulation of cell migration. This study was undertaken, to gain more insight on the role of PSMA in early prostate cancer and its distribution in various normal tissues. METHODS: A total of 1,700 different prostate cancers treated by radical prostatectomy and 612 samples from 76 different normal tissue types were successfully analyzed by immunohistochemistry (IHC) in a tissue microarray (TMA) format. PSMA immunostaining in cancers was also compared with clinical follow‐up, preexisting HER2 expression and Ki67 labeling index data. RESULTS: PSMA staining was only found in prostate epithelium and expression was higher in cancer cells than in benign tissue. PSMA staining was found in 94.1% of cancers and was significantly associated with tumor stage, high Gleason grade, preoperative PSA, and HER2 expression ( P < 0.0001 each). Tumors with strong PSMA expression had a higher risk of biochemical recurrence than cancers with only weak PSMA staining intensity ( P = 0.0483). There was no significant association between PSMA expression and Ki67 labeling index ( P = 0.442). CONCLUSIONS: Based on the high frequency of PSMA overexpression in all stages and grades of prostate cancer and the high prevalence of PSMA overexpression, it can be speculated that increased PSMA expression may be related with prostate cancer development rather than progression. The known function of PSMA activating cell migration would be in line with the suggested role in cancer progression and the missing association between PSMA overexpression and tumor cell proliferation. Prostate 71:281–288, 2011. © 2010 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/pros.21241

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 46 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Minner, S., Wittmer, C., Graefen, M., Salomon, G., Steuber, T., Haese, A., Huland, H., Bokemeyer, C., Yekebas, E., Dierlamm, J., Balabanov, S., Kilic, E., Wilczak, W., Simon, R., Sauter, G., & Schlomm, T.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Minner, Sarah
Venue
The Prostate
Publisher
Wiley
Published
2010-08-31
Volume
71
Issue
3
Pages
281-288
ISSN
  • 0270-4137 (ISSN-L)
  • 1097-0045
OpenAlex
W1977388865
Cited by
284
References
46
Citations by year
2026: 9 · 2025: 19 · 2024: 18 · 2023: 28 · 2022: 22 · 2021: 34 · 2020: 18 · 2019: 28 · 2018: 19 · 2017: 24 · 2016: 16 · 2015: 6 · 2014: 14 · 2013: 16 · 2012: 7
FWCI
7.71
Type
journal article
Language
en
Open access
closed
Locations
  • The Prostate (publishedVersion)
  • PubMed (publishedVersion)
Funders
Federalno Ministarstvo Obrazovanja i Nauke
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
prostate-specific membrane antigen, prostate cancer, biochemical recurrence, radical prostatectomy, Gleason grade, tumor stage, HER2 expression, Ki-67 proliferation index, cell migration, tumor cell proliferation, tissue microarray
MeSH terms
Adult, Aged, Antigens, Surface, Humans, Male, Middle Aged, Prognosis, Prostatic Neoplasms, Multivariate Analysis, Prostate-Specific Antigen, Erb-b2 Receptor Tyrosine Kinases, Ki-67 Antigen, Glutamate Carboxypeptidase II, Tissue Array Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review