The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Generation and metabolism of bioactive sphingosine‐1‐phosphate
Abstract
Sphingosine‐1‐phosphate (S1P) is a bioactive lysosphingophospholipid that has been implicated in the regulation of vital biological processes. Abundant evidence indicates that S1P acts as both an intracellular messenger and an extracellular ligand for a family of five specific G protein‐coupled S1P receptors (S1PRs). Cellular levels of S1P are tightly regulated in a spatio‐temporal manner through its synthesis catalyzed by sphingosine kinases (SphKs) and degradation by S1P lyase (SPL) and specific S1P phosphohydrolases. Over the past decade, the identification and cloning of genes encoding S1P metabolizing enzymes has increased rapidly. Overexpression and deletion of these enzymes has provided important insights into the intracellular and the “inside‐out” functions of S1P. The purpose of this review is to summarize the current knowledge of S1P metabolizing enzymes, their enzymatic properties, and their roles in the control of cellular functions by S1P. © 2004 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases
Billich, A., Bornancin, F., Dévay, P., Mechtcheriakova, D., Urtz, N., & Baumruker, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307687200 · Cited by 433
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
Igarashi, N., Okada, T., Hayashi, S., Fujita, T., Jahangeer, S., & Nakamura, S.-I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306577200 · Cited by 415
Cited by
Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
Schwab, S. R., Pereira, J. P., Matloubian, M., Xu, Y., Huang, Y., & Cyster, J. G. (2005) · Science · doi:10.1126/science.1113640 · Cited by 787
Sphingosine 1-phosphate signalling
Mendelson, K., Evans, T., & Hla, T. (2014) · Development · doi:10.1242/dev.094805 · Cited by 309
Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
Kamphuis, E., Junt, T., Waibler, Z., Forster, R., & Kalinke, U. (2006) · Blood · doi:10.1182/blood-2006-06-027599 · Cited by 306
Glycosphingolipids—Nature, Function, and Pharmacological Modulation
Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902620 · Cited by 288
Pérez-Jeldres, T., Tyler, C. J., Boyer, J. D., Karuppuchamy, T., Yarur, A., Giles, D. A., Yeasmin, S., Lundborg, L., Sandborn, W. J., Patel, D. R., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00212 · Cited by 126
Metadata
- Authors
- Stunff, H. L., Milstien, S., & Spiegel, S.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2004-05-05
- Volume
- 92
- Issue
- 5
- Pages
- 882-899
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2108825594
- Cited by
- 201
- References
- 2
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
