Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
Abstract
Exposure to asbestos causes cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The pathogenesis of asbestos-related diseases is complicated and still poorly understood. Studies on animal models and cell cultures have indicated that asbestos fibers generate reactive oxygen and nitrogen species (ROS/RNS) and cause oxidation and/or nitrosylation of proteins and DNA. The ionic state of iron and its ability to be mobilized determine the oxidant-inducing potential of pathogenic iron-containing asbestos types. In addition to their capacity to damage macromolecules, oxidants play important roles in the initiation of numerous signal transduction pathways that are linked to apoptosis, inflammation, and proliferation. There is strong evidence supporting the premise that oxidants contribute to asbestos-induced lung injury; thus, strategies for reducing oxidant stress to pulmonary cells may attenuate the deleterious effects of asbestos.
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Iron-generated free radicals are largely held as one of the causes of asbestos malignant effect.
“In asbestos toxicology, iron-generated free radicals are largely held as one of the causes of asbestos malignant effect.”
From Surface reactivity of amphibole asbestos: a comparison between crocidolite and tremolite (2017) · cites this paper as [2]
Asbestos fibres can undergo redox reactions that produce ROS, which are associated with inflammatory and carcinogenic signalling.
“Asbestos fibres have been shown to participate in redox reactions to generate reactive oxygen species (ROS) that are widely linked to signalling pathways causing inflammation and carcinogenesis [reviewed in (17)].”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [17]
The amount of ROS produced tracks with how toxic and pathogenic different asbestos varieties are.
“The generation of ROS correlates with toxicity and pathogenicity of different types of asbestos.”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [17]
Ascorbic acid normally occurs in the lung lining layer at a lower concentration than used in the test and is one of several metabolites that can act as reductant in vivo.
“Ascorbic acid, which normally occurs in the lung lining layer -though at a lower concentration than that used in the test-, is only one from several metabolites that can act as reductant in vivo.[30]”
From The Iron‐Related Molecular Toxicity Mechanism of Synthetic Asbestos Nanofibres: A Model Study for High‐Aspect‐Ratio Nanoparticles (2011) · cites this paper as [30]
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
Wagner, J. C., Sleggs, C. A., & Marchand, P. (1960) · Occupational and Environmental Medicine · doi:10.1136/oem.17.4.260 · Cited by 1,865 · see citing works
Mechanisms in the Pathogenesis of Asbestosis and Silicosis
MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9707141 · Cited by 971 · see citing works
Self-citationAsbestos: Scientific Developments and Implications for Public Policy
Mossman, B. T., Bignon, J., Corn, M., Seaton, A., & Gee, J. B. L. (1990) · Science · doi:10.1126/science.2153315 · Cited by 742 · see citing works
Self-citationManna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563 · see citing works
Mossman, B. T., & Gee, J. B. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906293202604 · Cited by 504 · see citing works
Self-citationMohanty, J. G., Jaffe, J. S., Schulman, E. S., & Raible, D. G. (1997) · Journal of Immunological Methods · doi:10.1016/s0022-1759(96)00244-x · Cited by 496 · see citing works
The molecular basis of asbestos induced lung injury
Kamp, D. W., & Weitzman, S. A. (1999) · Thorax · doi:10.1136/thx.54.7.638 · Cited by 345 · see citing works
Self-citationKuwano, K., Kunitake, R., Kawasaki, M., Nomoto, Y., Hagimoto, N., Nakanishi, Y., & Hara, N. (1996) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.154.2.8756825 · Cited by 339 · see citing works
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
Weitzman, S. A., & Graceffa, P. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90078-x · Cited by 292 · see citing works
Apoptosis and Expression of Fas/Fas Ligand mRNA in Bleomycin-Induced Pulmonary Fibrosis in Mice
Hagimoto, N., Kuwano, K., Nomoto, Y., Kunitake, R., & Hara, N. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.1.8998084 · Cited by 273 · see citing works
Health Effects of Mineral Dusts
(1993) · De Gruyter eBooks · doi:10.1515/9781501509711 · Cited by 268 · see citing works
Oxygen Toxicity in Mouse Lung: Pathways to Cell Death
Barazzone‐Argiroffo, C., Horowitz, S., Donati, Y. R. A., Rodríguez, I., & Piguet, P. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.4.3173 · Cited by 258 · see citing works
Cell cycle kinetics in the alveolar epithelium
Uhal, B. D. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.6.l1031 · Cited by 228 · see citing works
Hansen, K., & Mossman, B. T. (1987) · PubMed · Cited by 227 · see citing works
Self-citationRole of mesenchymal cell death in lung remodeling after injury.
Polunovsky, V. A., Chen, B., Henke, C., Snover, D. C., Wendt, C. H., Ingbar, D. H., & Bitterman, P. B. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116578 · Cited by 212 · see citing works
Persistent induction of c-fos and c-jun expression by asbestos.
Heintz, N. H., Janssen, Y. M., & Mossman, B. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3299 · Cited by 205 · see citing works
Self-citationMechanisms of Carcinogenesis and Clinical Features of Asbestos-Associated Cancers
Mossman, B. T., Kamp, D. W., & Weitzman, S. A. (1996) · Cancer Investigation · doi:10.3109/07357909609018904 · Cited by 197 · see citing works
Self-citationAust, A. E., & Eveleigh, J. F. (1999) · Proceedings of the Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-141.x · Cited by 191 · see citing works
McClintock, D. S., Santore, M. T., Lee, V. Y., Brunelle, J. K., Budinger, G. R. S., Zong, W., Thompson, C. B., Hay, N., & Chandel, N. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.94-104.2002 · Cited by 182 · see citing works
Janssen-Heininger, Y. M. W., Barchowsky, A., Treadwell, M. D., Driscoll, K. E., & Mossman, B. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8458 · Cited by 178 · see citing works
Self-citationGlutathione Redox System in Oxidative Lung Injury
Rahman, Q., Abidi, P., Afaq, F., Schiffmann, D., Mossman, B. T., Kamp, D. W., & Athar, M. (1999) · Critical Reviews in Toxicology · doi:10.1080/10408449991349276 · Cited by 176 · see citing works
Self-citationRole of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages.
Goodglick, L., & Kane, A. B. (1986) · PubMed · Cited by 173 · see citing works
Mossman, B. T., Marsh, J. P., Sesko, A., Hill, S., Shatos, M. A., Doherty, J., Petruska, J., Adler, K. B., Hemenway, D., Mickey, R., et al. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.5_pt_1.1266 · Cited by 163 · see citing works
Self-citationBroaddus, V. C., Yang, L., Scavo, L. M., Ernst, J. D., & Boylan, A. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119010 · Cited by 161 · see citing works
Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica.
Janssen-Heininger, Y. M. W., Marsh, J. P., Absher, M. P., Hemenway, D. R., Vacek, P. M., Leslie, K. O., Borm, P. J. A., & Mossman, B. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50063-1 · Cited by 157 · see citing works
Self-citationRole of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2
Jiménez, L. A., Zanella, C. L., Fung, H., Janssen-Heininger, Y. M. W., Vacek, P., Charland, C., Goldberg, J. L., & Mossman, B. T. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.5.l1029 · Cited by 154 · see citing works
Self-citationRepair of DNA damage in mitochondria
Sawyer, D. E., & Houten, B. V. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00027-0 · Cited by 147 · see citing works
Role and regulation of activator protein-1 in toxicant-induced responses of the lung
Reddy, S. P., & Mossman, B. T. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00140.2002 · Cited by 147 · see citing works
Self-citationSimeonova, P. P., & Luster, M. I. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.12.6.7539275 · Cited by 137 · see citing works
Zwacka, R. M., Dudus, L., Epperly, M. W., Greenberger, J. S., & Engelhardt, J. F. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.9-1381 · Cited by 127 · see citing works
Simeonova, P. P., Toriumi, W., Kommineni, C., Erkan, M., Munson, A. E., Rom, W. N., & Luster, M. I. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.8.3921 · Cited by 124 · see citing works
Chrysotile fiber is a strong mutagen in mammalian cells.
Hei, T. K., Piao, C. Q., He, Z. Y., Vannais, D. B., & Waldren, C. A. (1992) · PubMed · Cited by 122 · see citing works
Self-citationTanaka, S., Choe, N., Hemenway, D. R., Zhu, S., Matalon, S., & Kagan, E. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3169 · Cited by 121 · see citing works
Reactive Oxygen Species and Cell Signaling
Hoidal, J. R. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.6.f213 · Cited by 118 · see citing works
Chao, C.-C., Park, S.-H., & Aust, A. E. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0059 · Cited by 118 · see citing works
Brody, A. R., & Overby, L. H. (1989) · PubMed · Cited by 113 · see citing works
Kamp, D. W., Israbian, V. A., Preusen, S. E., Zhang, C. X., & Weitzman, S. A. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.3.l471 · Cited by 112 · see citing works
Self-citationHancock, J. T., Desikan, R., & Neill, S. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00646-3 · Cited by 109 · see citing works
Ceramide-Mediated Apoptosis in Lung Epithelial Cells Is Regulated by Glutathione
Lavrentiadou, S. N., Chan, C. C.-S., Kawcak, T., Ravid, T., Tsaba, A., van der Vliet, A., Rasooly, R., & Goldkorn, T. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.6.4321 · Cited by 108 · see citing works
Pache, J. C., Janssen-Heininger, Y. M. W., Walsh, E. S., Quinlan, T. R., Zanella, C. L., Low, R. B., Taatjes, D. J., & Mossman, B. T. (1998) · Europe PMC (PubMed Central) · Cited by 106 · see citing works
Self-citationDifferential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS
Janssen, Y. M. W., Matalon, S., & Mossman, B. T. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.4.l789 · Cited by 105 · see citing works
Self-citationXu, A., Wu, L., Santella, R. M., & Hei, T. K. (1999) · PubMed · Cited by 101 · see citing works
Self-citationChoe, N., Tanaka, S., & Kagan, E. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.2.3111 · Cited by 95 · see citing works
Apoptosis is Observed in Mesothelial Cells After Exposure to Crocidolite Asbestos
BéruBé, K., Quinlan, T. R., Fung, H., Magae, J., Vacek, P. M., Taatjes, D. J., & Mossman, B. T. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679218 · Cited by 95 · see citing works
Self-citationAsbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis
Shukla, A., Jung, M., Stern, M., Fukagawa, N. K., Taatjes, D. J., Sawyer, D. E., Houten, B. V., & Mossman, B. T. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00038.2003 · Cited by 94 · see citing works
Self-citationAsbestos causes apoptosis in alveolar epithelial cells: Role of iron-induced free radicals
Aljandali, A., Pollack, H., Yeldandi, A., LI, Y., Weitzman, S. A., & Kamp, D. W. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.114826 · Cited by 92 · see citing works
Self-citationAsbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fosand apoptosis
Zanella, C. L., Timblin, C. R., Cummins, A. B., Jung, M., Goldberg, J. L., Raabe, R., Tritton, T. R., & Mossman, B. T. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.4.l684 · Cited by 92 · see citing works
Self-citationResistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax
Narasimhan, S. R., Yang, L., Gerwin, B. I., & Broaddus, V. C. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.1.l165 · Cited by 91 · see citing works
Kamp, D. W., Panduri, V., Weitzman, S. A., & Chandel, N. S. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015949118495 · Cited by 91 · see citing works
Self-citationIron mobilization from asbestos by chelators and ascorbic acid
Lund, L. G., & Aust, A. E. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90231-m · Cited by 87 · see citing works
Asbestos Induction of Nuclear Transcription Factors and Interleukin 8 Gene Regulation
Simeonova, P. P., & Luster, M. I. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.6.8969274 · Cited by 87 · see citing works
Gilmour, P. S., Brown, D. M., Beswick, P. H., MacNee, W., Rahman, I., & Donaldson, K. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51313 · Cited by 86 · see citing works
Boylan, A. M., Sanan, D. A., Sheppard, D., & Broaddus, V. C. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118246 · Cited by 86 · see citing works
Fung, H., Kow, Y. W., Houten, B. V., Taatjes, D. J., Hatahet, Z., Janssen-Heininger, Y. M. W., Vacek, P., Faux, S. P., & Mossman, B. T. (1998) · PubMed · Cited by 85 · see citing works
Self-citationFenoglio, I., Prandi, L., Tomatis, M., & Fubini, B. (2001) · Redox Report · doi:10.1179/135100001101536382 · Cited by 84 · see citing works
Quinlan, T. R., BéruBé, K., Hacker, M. P., Taatjes, D. J., Timblin, C. R., Goldberg, J. L., Kimberley, P., O’Shaughnessy, P. T., Hemenway, D. R., Torino, J., et al. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00357-2 · Cited by 82 · see citing works
Self-citationMechanisms in Fibre Carcinogenesis
Brown, R. C., Hoskins, J. A., & Johnson, N. F. (1991) · Springer eBooks · doi:10.1007/978-1-4684-1363-2 · Cited by 81 · see citing works
Asbestos induces apoptosis in human alveolar macrophages
Hamilton, R. F., Iyer, L. L., & Holian, A. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.271.5.l813 · Cited by 81 · see citing works
Pleural macrophage recruitment and activation in asbestos-induced pleural injury.
Choe, N., Tanaka, S., Xia, W., Hemenway, D. R., Roggli, V. L., & Kagan, E. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51257 · Cited by 80 · see citing works
Lakshmikuttyamma, A., & Vijayammal, P. L. (1996) · Journal of Applied Toxicology · doi:10.1002/(sici)1099-1263(199607)16:4 · Cited by 78 · see citing works
Hydroxyl radical production in the presence of fibres by a fenton-type reaction
Gulumian, M., & Van Wyk, J. A. (1987) · Chemico-Biological Interactions · doi:10.1016/0009-2797(87)90081-0 · Cited by 71 · see citing works
Self-citationBrass, D. M., Hoyle, G. W., Poovey, H. G., Liu, J., & Brody, A. R. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65332-1 · Cited by 66 · see citing works
Faux, S. P., & Howden, P. J. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51127 · Cited by 60 · see citing works
Contribution of reactive oxygen and nitrogen species to particulate-induced lung injury.
Zhu, S., Manuel, M., Tanaka, S., Choe, N., Kagan, E., & Matalon, S. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s51157 · Cited by 60 · see citing works
Park, S. H., & Aust, A. E. (1998) · PubMed · Cited by 59 · see citing works
Non-occupational exposure to mineral fibres
Seaton, A. (1989) · Journal of Epidemiology & Community Health · doi:10.1136/jech.43.4.404 · Cited by 57 · see citing works
Effects of Mineral Dusts on Cells
Mossman, B. T., & Begin, R. O. (1989) · Springer eBooks · doi:10.1007/978-3-642-74203-3 · Cited by 55 · see citing works
Self-citationCell signaling pathways elicited by asbestos.
Mossman, B. T., Faux, S. G., Janssen-Heininger, Y. M. W., Jimenez, L. A., Timblin, C. R., Zanella, C., Goldberg, J. L., Walsh, E., Barchowsky, A., & Driscoll, K. E. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51121 · Cited by 53 · see citing works
Self-citationAyoub, J., Jean-François, R., Cormier, Y. F., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.11.3546 · Cited by 53 · see citing works
Induction of Ferritin Synthesis in Human Lung Epithelial Cells Treated with Crocidolite Asbestos
Fang, R., & Aust, A. E. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9892 · Cited by 52 · see citing works
Asbestos induces inflammatory cytokines in the lung through redox sensitive transcription factors
Luster, M. I., & Simeonova, P. P. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00321-x · Cited by 49 · see citing works
Flaherty, D. M., Monick, M. M., Carter, A. B., Peterson, M. W., & Hunninghake, G. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5675 · Cited by 48 · see citing works
Asbestos-induced decomposition of hydrogen peroxide
Eberhardt, M. K., Román-Franco, A. A., & Quiles, M. R. (1985) · Environmental Research · doi:10.1016/0013-9351(85)90108-2 · Cited by 47 · see citing works
Pezerat, H., Zalma, R., Guignard, J., & Jaurand, M. (1989) · PubMed · Cited by 46 · see citing works
Dai, J. M., & Churg, A. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.4.4225 · Cited by 46 · see citing works
Jung, M., Davis, W. P., Taatjes, D. J., Churg, A., & Mossman, B. T. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00211-2 · Cited by 45 · see citing works
Self-citationStudies on surface properties of asbestos
Bonneau, L., Suquet, H., Malard, C., et al. (1986) · Environmental Research · doi:10.1016/s0013-9351(86)80187-6 · Cited by 43 · see citing works
Howden, P. J., & Faux, S. P. (1996) · Carcinogenesis · doi:10.1093/carcin/17.3.413 · Cited by 43 · see citing works
Mossman, B. T., Surinrut, P., Brinton, B. T., Marsh, J. P., Heintz, N. H., Lindau‐Shepard, B., & Shaffer, J. B. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00014-7 · Cited by 42 · see citing works
Self-citationIn Vivo Evidence of Free Radical Formation After Asbestos Instillation
Ghio, A. J., Kadiiska, M. B., Xiang, Q.-H., & Mason, R. P. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00063-4 · Cited by 42 · see citing works
Driscoll, K. E., Carter, J. M., Howard, B. W., Hassenbein, D. G., Janssen-Heininger, Y. M. W., & Mossman, B. T. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s51171 · Cited by 41 · see citing works
Self-citationGeneration of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]
Ghio, A. J., Zhang, J., & Piantadosi, C. A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90461-5 · Cited by 40 · see citing works
Iron Mobilization from Crocidolite Asbestos by Human Lung Carcinoma Cells
Chao, C. C., Lund, L. G., Zinn, K. R., et al. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1457 · Cited by 39 · see citing works
Chao, C. C., & Aust, A. E. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1009 · Cited by 36 · see citing works
Production of hydroxyl radicals by iron solid compounds†
Zalma, R., Bonneau, L., Guignard, J., Pezerat, H., & Jaurand, M. (1987) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248709357180 · Cited by 35 · see citing works
Loss of imprinting of igf2 in renal-cell carcinomas
Oda, H., Kume, H., Shimizu, Y., Inoue, T., & Ishikawa, T. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980130)75:3 · Cited by 33 · see citing works
Merkel cells in the human oesophagus
Harmse, J. L., Carey, F. A., Baird, A., Craig, S., Christie, K. N., Hopwood, D., & Lucocq, J. M. (1999) · Journal of Pathology · doi:10.1002/(sici)1096-9896(199910)189:2 · Cited by 33 · see citing works
Faux, S. P., Howden, P. J., & Levy, L. S. (1994) · Carcinogenesis · doi:10.1093/carcin/15.8.1749 · Cited by 33 · see citing works
Ramos‐Niño, M. E., Haegens, A., Shukla, A., & Mossman, B. T. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015924413043 · Cited by 30 · see citing works
Self-citationRamos‐Niño, M. E., Haegens, A., Shukla, A., & Mossman, B. T. (2002) · Springer eBooks · doi:10.1007/978-1-4615-1087-1_12 · Cited by 29 · see citing works
Self-citationPleural Macrophage Recruitment and Activation in Asbestos-Induced Pleural Injury
Choe, N., Tanaka, S., Xia, W., Hemenway, D. R., Roggli, V. L., & Kagan, E. (1997) · Environmental Health Perspectives · doi:10.2307/3433543 · Cited by 29 · see citing works
Both, K., Henderson, D. W., & Turner, D. R. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590417 · Cited by 27 · see citing works
Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages
Aldieri, E., Ghigo, D., Tomatis, M., Prandi, L., Fenoglio, I., Costamagna, C., Pescarmona, G., Bosìa, A., & Fubini, B. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00612-8 · Cited by 26 · see citing works
Role of Transcription Factor NF-κB in Asbestos-Induced TNFα Response from Macrophages
Cheng, N., Shi, X., Ye, J., Castranova, V., Chen, F., Leonard, S. S., Vallyathan, V., & Rojanasakul, Y. (1999) · Experimental and Molecular Pathology · doi:10.1006/exmp.1999.2268 · Cited by 26 · see citing works
Differential Patterns of Apoptosis in Resolving and Nonresolving Bacterial Pneumonia
Kazzaz, J. A., Horowitz, S., Xu, J., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9806158 · Cited by 26 · see citing works
Involvement of hydrogen peroxide in asbestos-induced NFAT activation
Li, J., Huang, C., Huang, B., Shi, X., Castranova, V., & Vallyathan, V. (2002) · Springer eBooks · doi:10.1007/978-1-4615-1087-1_18 · Cited by 23 · see citing works
Gibb, T. C., & Greenwood, N. N. (1965) · Transactions of the Faraday Society · doi:10.1039/tf9656101317 · Cited by 22 · see citing works
Involvement of hydrogen peroxide in asbestos-induced NFAT activation
Li, J., Huang, B., Shi, X., Castranova, V., Vallyathan, V., & Huang, C. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015962916195 · Cited by 19 · see citing works
Activation of UICC Crocidolite: The Effect of Conversion of Some Ferric Ions to Ferrous Ions
Gulumian, M., Bhoolia, D. J., Dutoit, R. S. J., Rendall, R. E. G., Pollak, H., Vanwyk, J. A., & Rhempula, M. (1993) · Environmental Research · doi:10.1006/enrs.1993.1027 · Cited by 18 · see citing works
Self-citationHowden, P. J., & Faux, S. P. (1996) · Carcinogenesis · doi:10.1093/carcin/17.10.2275 · Cited by 18 · see citing works
Fisher, C. E. (1998) · The Annals of Occupational Hygiene · doi:10.1016/s0003-4878(98)00022-2 · Cited by 17 · see citing works
Faux, S. P., & Howden, P. J. (1997) · Environmental Health Perspectives · doi:10.2307/3433520 · Cited by 16 · see citing works
Etude des sites donneurs et accepteurs d’un électron en surface des amiantes
Bonneau, L., & Pezerat, H. (1983) · Journal de Chimie Physique · doi:10.1051/jcp/1983800275 · Cited by 14 · see citing works
Gilmour, P. S., Brown, D. M., Beswick, P. H., et al. (1997) · Environmental Health Perspectives · doi:10.2307/3433553 · Cited by 14 · see citing works
Contribution of Reactive Oxygen and Nitrogen Species to Particulate-Induced Lung Injury
Zhu, S., Manuel, M., Tanaka, S., Choe, N., Kagan, E., & Matalon, S. (1998) · Environmental Health Perspectives · doi:10.2307/3433979 · Cited by 14 · see citing works
Asbestos‐induced Nitric Oxide Production: Synergistic Effect with Interferon‐γ
THOMAS, G., ANDO, T., Verma, K., et al. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39803.x · Cited by 13 · see citing works
Gulumian, J. A., Bhoolia, Theodorou, Rollin, Pollak, & Wyk, V. (1993) · South African Journal of Science · Cited by 13 · see citing works
Bulk and surface modifications in detoxified crocidolite
Hearne, G. R., Kolk, B., Pollak, H., van Wyk, J. A., & Gulumian, M. (1993) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(93)80021-z · Cited by 12 · see citing works
Self-citationESR and Mössbauer studies on detoxified crocidolite: Mechanism of reduced toxicity
Gulumian, M., van Wyk, J. A., Hearne, G. R., Kolk, B., & Pollak, H. (1993) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(93)80020-a · Cited by 12 · see citing works
Self-citationCell Signaling Pathways Elicited by Asbestos
Mossman, B. T., Faux, S. G., Janssen-Heininger, Y. M. W., Jimenez, L. A., Timblin, C. R., Zanella, C. L., Goldberg, J., Walsh, E., Barchowsky, A., & Driscoll, K. E. (1997) · Environmental Health Perspectives · doi:10.2307/3433519 · Cited by 12 · see citing works
Self-citationGulumian, M., van Wyk, J. A., & Kolk, B. (1989) · Springer eBooks · doi:10.1007/978-3-642-74203-3_26 · Cited by 10 · see citing works
Self-citationCan microwave radiation at high temperatures reduce the toxicity of fibrous crocidolite asbestos?
Gulumian, M., Nkosibomvu, Z. L., Channa, K., & Pollak, H. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51041 · Cited by 6 · see citing works
Self-citationAn investigation of the mechanism of detoxification in asbestos
Hearne, G. R., Pollak, H., van Wyk, J. A., et al. (1992) · Hyperfine Interactions · doi:10.1007/bf02418612 · Cited by 6 · see citing works
Driscoll, K. E., Carter, J. M., Howard, B. W., et al. (1998) · Environmental Health Perspectives · doi:10.2307/3433981 · Cited by 6 · see citing works
Gulumian, M., & Pollak, H. (1998) · Hyperfine Interactions · doi:10.1023/a:1012630423172 · Cited by 4 · see citing works
Self-citationOxygen Consumption, Lipid Peroxidation and Mineral Fibres
Gulumian, M., & van Wyk, J. A. (1991) · Springer eBooks · doi:10.1007/978-1-4684-1363-2_37 · Cited by 4 · see citing works
Self-citationCan Microwave Radiation at High Temperatures Reduce the Toxicity of Fibrous Crocidolite Asbestos?
Gulumian, M., Nkosibomvu, Z. L., Channa, K., & Pollak, H. (1997) · Environmental Health Perspectives · doi:10.2307/3433506 · Cited by 3 · see citing works
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
Self-citationEnvironmental toxicity, oxidative stress and apoptosis: Ménage à Trois
Franco, R., Sánchez-Olea, R., Reyes-Reyes, E. M., & Panayiotidis, M. I. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.11.012 · Cited by 541 · see citing works
Valavanidis, A., Vlachogianni, T., & Fiotakis, K. (2009) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph6020445 · Cited by 519 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
Asbestos-induced lung diseases: an update
Kamp, D. W. (2009) · Translational Research · doi:10.1016/j.trsl.2009.01.004 · Cited by 251 · see citing works
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Liu, G., Cheresh, P., & Kamp, D. W. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163942 · Cited by 213 · see citing works
Self-citationSanchez, V. C., Pietruska, J. R., Miselis, N. R., Hurt, R. H., & Kane, A. B. (2009) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.41 · Cited by 186 · see citing works
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Huang, S. X. L., Jaurand, M.-C., Kamp, D. W., Whysner, J., & Hei, T. K. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556051 · Cited by 163 · see citing works
Self-citationMossman, B. T., Borm, P. J., Castranova, V., Costa, D. L., Donaldson, K., & Kleeberger, S. R. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-4 · Cited by 150 · see citing works
Self-citationMesothelioma: Do asbestos and carbon nanotubes pose the same health risk?
Jaurand, M.-C. F., Renier, A., & Daubriac, J. (2009) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-6-16 · Cited by 147 · see citing works
Reactive Oxygen Species a Double-Edged Sword for Mesothelioma
Benedetti, S., Nuvoli, B., Catalani, S., & Galati, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4253 · Cited by 97 · see citing works
Linnarsson, D., Carpenter, J., Fubini, B., Gerde, P., Karlsson, L. L., Loftus, D. J., Prisk, G. K., Staufer, U., Tranfield, E. M., & van Westrenen, W. (2012) · Planetary and Space Science · doi:10.1016/j.pss.2012.05.023 · Cited by 95 · see citing works
Gazzano, E., Turci, F., Foresti, E., Putzu, M. G., Aldieri, E., Silvagno, F., Lesci, I. G., Tomatis, M., Riganti, C., Romano, C., et al. (2007) · Chemical Research in Toxicology · doi:10.1021/tx600354f · Cited by 88 · see citing works
Turci, F., Tomatis, M., Lesci, I. G., Roveri, N., & Fubini, B. (2011) · Chemistry – A European Journal · doi:10.1002/chem.201001893 · Cited by 73 · see citing works
Sabo-Attwood, T., Ramos-Nino, M., Bond, J., Butnor, K. J., Heintz, N., Gruber, A. D., Steele, C., Taatjes, D. J., Vacek, P., & Mossman, B. T. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61212-6 · Cited by 72 · see citing works
Self-citationPadmore, T., Stark, C., Turkevich, L. A., & Champion, J. A. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.031 · Cited by 74 · see citing works
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Self-citationAung, W., Hasegawa, S., Furukawa, T., & Saga, T. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm090 · Cited by 62 · see citing works
Pollastri, S., D’Acapito, F., Trapananti, A., Colantoni, I., Andreozzi, G. B., & Gualtieri, A. F. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.05.010 · Cited by 51 · see citing works
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Urso, L., Cavallari, I., Sharova, E., Ciccarese, F., Pasello, G., & Ciminale, V. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0661-9 · Cited by 47 · see citing works
Bloise, A., Ricchiuti, C., Punturo, R., & Pereira, D. (2020) · Chemical Geology · doi:10.1016/j.chemgeo.2020.119896 · Cited by 46 · see citing works
Surface reactivity of amphibole asbestos: a comparison between crocidolite and tremolite
Andreozzi, G. B., Pacella, A., Corazzari, I., Tomatis, M., & Turci, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-14480-z · Cited by 42 · see citing works
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Damby, D. E., Horwell, C. J., Baxter, P. J., Kueppers, U., Schnurr, M., Dingwell, D. B., & Duewell, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.02000 · Cited by 41 · see citing works
Pacella, A., Fantauzzi, M., Turci, F., Cremisini, C., Montereali, M. R., Nardi, E., Atzei, D., Rossi, A., & Andreozzi, G. B. (2014) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2013.11.035 · Cited by 26 · see citing works
Asbestos Exposure Induces Alveolar Epithelial Cell Plasticity through MAPK/Erk Signaling
Tamminen, J. A., Myllärniemi, M., Hyytiäinen, M., Keski‐Oja, J., & Koli, K. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24094 · Cited by 25 · see citing works
Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials
Felley-Bosco, E., & MacFarlane, M. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00146 · Cited by 23 · see citing works
Role of asbestos in etiology of malignant pleural mesothelioma
Godleski, J. J. (2004) · Thoracic Surgery Clinics · doi:10.1016/s1547-4127(04)00111-2 · Cited by 24 · see citing works
Gulino, G. R., Polimeni, M., Prato, M., Gazzano, E., Kopecka, J., Colombatto, S., Ghigo, D., & Aldieri, E. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1409627 · Cited by 22 · see citing works
Schiavello, M., Gazzano, E., Bergandi, L., Silvagno, F., Libener, R., Riganti, C., & Aldieri, E. (2021) · Cancers · doi:10.3390/cancers13051138 · Cited by 8 · see citing works
RetractedCastellini, E., & Gualtieri, A. F. (2026) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6c00003
- Authors
- Shukla, A., Gulumian, M., Hei, T. K., Kamp, D., Rahman, Q., & Mossman, B. T.
- Affiliations
- University of Vermont (US)
- University of the Witwatersrand (ZA)
- Columbia University (US)
- Northwestern University (US)
- Indian Institute of Toxicology Research (IN)
- Corresponding author
- Mossman, Brooke T.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 34
- Issue
- 9
- Pages
- 1117-1129
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1981158444
- Semantic Scholar
- 37d4f08bb05c469c38561e8d4d21010ceab344e3
- Cited by
- 288
- References
- 118
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 14
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- asbestos, oxidizing agents, reactive oxygen species, reactive nitrogen species, asbestosis, mesothelioma, lung cancer, iron, nitrosylation, DNA oxidation, protein oxidation, signal transduction, apoptosis, inflammation, cell proliferation, lung injury, oxidative stress
- MeSH terms
- Animals, Asbestos, Humans, Inflammation, Lung, Lung Diseases, Oxidants, Reactive Oxygen Species, Reactive Nitrogen Species
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