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Cited by 258

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT‐like phenotype change and MMP‐9‐mediated degradation of E‐cadherin

Zuo, Jian‐Hong, Zhu, Wei, Li, Mao‐Yu, Li, Xin‐Hui, Yi, Hong, Zeng, Gu‐Qing, Wan, Xun‐Xun, He, Qiu‐Yan, Li, Jian‐Huang, Qu, Jia‐Quan, Chen, Yu, Xiao, Zhi‐Qiang·2011·Journal of Cellular Biochemistry
DOI 10.1002/jcb.23175
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Abstract

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell invasion and metastasis still need to be elucidated. In this study, we showed that activation of EGFR by EGF in HNSCC cell line SCC10A enhanced cell migration and invasion, and induced loss of epitheloid phenotype in parallel with downregulation of E‐cadherin and upregulation of N‐cadherin and vimentin, indicating that EGFR promoted SCC10A cell migration and invasion possibly by an epithelial to mesenchymal transition (EMT)‐like phenotype change. Interestingly, activation of EGFR by EGF induced production of matrix metalloproteinase‐9 (MMP‐9) and soluble E‐cadherin (sE‐cad), and knockdown of MMP‐9 by siRNA inhibited sE‐cad production induced by EGF in SCC10A. Moreover, both MMP‐9 knockdown and E‐cadherin overexpression inhibited cell migration and invasion induced by EGF in SCC10A. The results indicate that EGFR activation promoted cell migration and invasion through inducing MMP‐9‐mediated degradation of E‐cadherin into sE‐cad. Pharmacologic inhibition of EGFR, MEK, and PI3K kinase activity in SCC10A reduced phosphorylated levels of ERK‐1/2 and AKT, production of MMP‐9 and sE‐cad, cell migration and invasion, and expressional changes of EMT markers (E‐cadherin and N‐cadherin) induced by EGF, indicating that EGFR activation promotes cell migration and invasion via ERK‐1/2 and PI3K‐regulated MMP‐9/E‐cadherin signaling pathways. Taken together, the data suggest that EGFR activation promotes HNSCC SCC10A cell migration and invasion by inducing EMT‐like phenotype change and MMP‐9‐mediated degradation of E‐cadherin into sE‐cad related to activation of ERK‐1/2 and PI3K signaling pathways. J. Cell. Biochem. 112: 2508–2517, 2011. © 2011 Wiley‐Liss, Inc.

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Metadata

Authors
Zuo, J., Zhu, W., Li, M., Li, X., Yi, H., Zeng, G., Wan, X., He, Q., Li, J., Qu, J., Chen, Y., & Xiao, Z.
Venue
Journal of Cellular Biochemistry
Publisher
Wiley
Published
2011-08-18
Volume
112
Issue
9
Pages
2508-2517
ISSN
  • 0730-2312 (ISSN-L)
  • 1097-4644
DOI
10.1002/jcb.23175
OpenAlex
W1972316552
Cited by
258
References
40
FWCI
10.62
Type
journal article
Language
en
Open access
closed

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