The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Matrix metalloproteases in head and neck cancer
Open accessAbstract
Matrix metalloproteases (MMPs) are a collection of enzymes capable of cleaving extracellular matrix components, growth factors, and cell‐surface receptors. MMPs modulate most aspects of tumorigenesis and are highly expressed in cancer compared with normal tissues. Preclinical studies have demonstrated that head and neck squamous cell carcinomas (HNSCCs) express high levels of MMPs in vivo and that inhibition of these enzymes in vitro and in mouse models decreases invasion and metastasis. However, the clinical trials for MMP inhibitors have failed to demonstrate a significant survival advantage in most cancers. The disparity between preclinical and clinical studies has led to the reevaluation of how MMP functions in cancer and the design of clinical trials for molecularly targeted agents. Mouse model data and analysis of HNSCC tumor specimens suggests that membrane type‐1 MMP (MT1‐MMP) may be a critical enzyme in tumor cell invasion and survival in vivo. This accumulated data provide evidence for development of selective MT1‐MMP inhibitors as therapy in HNSCC. © 2005 Wiley Periodicals, Inc. Head Neck, 2006
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Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Strategies for MMP inhibition in cancer: innovations for the post-trial era
Overall, C. M., & López-Otín, C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc884 · Cited by 1,349
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306
Yang, L., DeBusk, L. M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. M., Carbone, D. P., & Lin, P. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.031 · Cited by 1,140
Self-citationEffects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice
Bergers, G., Javaherian, K., Lo, K.-M., Folkman, J., & Hanahan, D. (1999) · Science · doi:10.1126/science.284.5415.808 · Cited by 988
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression
Chung, C. H., Parker, J. S., Karaca, G., Wu, J., Funkhouser, W. K., Moore, D., Butterfoss, D., Xiang, D., Zanation, A., Yin, X., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00112-6 · Cited by 678
Cited by
The molecular biology of head and neck cancer
Leemans, C. R., Braakhuis, B. J. M., & Brakenhoff, R. H. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2982 · Cited by 2,524
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Transcriptomic dissection of tongue squamous cell carcinoma
Ye, H., Yu, T., Temam, S., Ziober, B. L., Wang, J., Schwartz, J. L., Mao, L., Wong, D. T., & Zhou, X. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-69 · Cited by 344
Nasopharyngeal carcinoma—Review of the molecular mechanisms of tumorigenesis
Chou, J., Lin, Y., Kim, J., You, L., Xu, Z., He, B., & Jablons, D. M. (2008) · Head & Neck · doi:10.1002/hed.20833 · Cited by 317
Zuo, J., Zhu, W., Li, M., Li, X., Yi, H., Zeng, G., Wan, X., He, Q., Li, J., Qu, J., et al. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23175 · Cited by 258
Metadata
- Authors
- Rosenthal, E. L., & Matrisian, L. M.
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2006-02-09
- Volume
- 28
- Issue
- 7
- Pages
- 639-648
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W1986863362
- Cited by
- 208
- References
- 6
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
